PMID- 36331350
OWN - NLM
STAT- MEDLINE
DCOM- 20230117
LR  - 20240305
IS  - 1365-2125 (Electronic)
IS  - 0306-5251 (Linking)
VI  - 89
IP  - 2
DP  - 2023 Feb
TI  - Do proton pump inhibitors increase the risk of dementia? A systematic review, 
      meta-analysis and bias analysis.
PG  - 602-616
LID - 10.1111/bcp.15583 [doi]
AB  - AIM: Previous studies on the association between proton pump inhibitor (PPI) 
      intake and the increased risk of dementia has shown discrepancies in their 
      conclusions. We aimed to provide updated evidence based on extensive bias 
      assessments and quantitative sensitivity analyses. METHODS: We searched the 
      databases PubMed, EMBASE, SCOPUS, CENTRAL and clinicaltrials.gov for prospective 
      studies that examined an association between PPI use and dementia, up to February 
      2022. Each study was assessed using the Cochrane risk of bias assessment tools 
      for non-randomized studies of interventions (ROBINS-I) or randomized trials 
      (RoB2). Pooled risk ratios (RRs) and 95% prediction intervals were computed using 
      random-effects models. Sensitivity analyses were adjusted for small-study bias. 
      RESULTS: We included nine observational studies with 204 108 dementia cases in 
      the primary analysis on the association between PPI use vs. non-use and dementia, 
      and the RR was 1.16 (95% CI = 1.00; 1.35). After adjusting for small-study bias 
      by Copas selection model and Rucker's shrinkage procedure, the RR was 1.16 (1.02; 
      1.32) and 1.15 (1.13; 1.17), respectively. A subgroup analysis of PPI use vs. 
      non-use regarding Alzheimer's disease risk yielded an RR of 1.15 (0.89; 1.50). 
      The secondary analysis on the risk of dementia by use of PPI vs. histamine-2 
      receptor antagonist showed an RR of 1.03 (0.66; 1.62). CONCLUSION: This 
      meta-analysis provided no clear evidence for an association between PPI intake 
      and the risk of dementia. Due to discrepancies in sensitivity analyses, however, 
      some risk of dementia by PPI use cannot be ruled out. Since an unequivocal 
      conclusion is still pending, further research is warranted.
CI  - (c) 2022 The Authors. British Journal of Clinical Pharmacology published by John 
      Wiley & Sons Ltd on behalf of British Pharmacological Society.
FAU - Ahn, Nayeon
AU  - Ahn N
AUID- ORCID: 0000-0003-4414-114X
AD  - Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), 
      Ludwig Maximilian University of Munich, Munich, Germany.
AD  - Chair of Epidemiology, University of Augsburg, University Hospital Augsburg, 
      Augsburg, Germany.
FAU - Nolde, Michael
AU  - Nolde M
AUID- ORCID: 0000-0001-6893-7367
AD  - Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), 
      Ludwig Maximilian University of Munich, Munich, Germany.
AD  - Chair of Epidemiology, University of Augsburg, University Hospital Augsburg, 
      Augsburg, Germany.
FAU - Krause, Evamaria
AU  - Krause E
AD  - Medical Library, Augsburg University Library, University of Augsburg, Augsburg, 
      Germany.
FAU - Guntner, Florian
AU  - Guntner F
AD  - Bereich Versorgungsmanagement, AOK Bayern, Munich, Germany.
FAU - Gunter, Alexander
AU  - Gunter A
AD  - Bereich Versorgungsmanagement, AOK Bayern, Munich, Germany.
FAU - Tauscher, Martin
AU  - Tauscher M
AD  - Association of Statutory Health Insurance Physicians in Bavaria, Kassenarztliche 
      Vereinigung Bayerns, KVB, Munich, Germany.
FAU - Gerlach, Roman
AU  - Gerlach R
AD  - Association of Statutory Health Insurance Physicians in Bavaria, Kassenarztliche 
      Vereinigung Bayerns, KVB, Munich, Germany.
FAU - Meisinger, Christa
AU  - Meisinger C
AD  - Chair of Epidemiology, University of Augsburg, University Hospital Augsburg, 
      Augsburg, Germany.
FAU - Linseisen, Jakob
AU  - Linseisen J
AD  - Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), 
      Ludwig Maximilian University of Munich, Munich, Germany.
AD  - Chair of Epidemiology, University of Augsburg, University Hospital Augsburg, 
      Augsburg, Germany.
FAU - Baumeister, Sebastian-Edgar
AU  - Baumeister SE
AD  - Institute of Health Services Research in Dentistry, University of Munster, 
      Munster, Germany.
FAU - Ruckert-Eheberg, Ina-Maria
AU  - Ruckert-Eheberg IM
AD  - Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), 
      Ludwig Maximilian University of Munich, Munich, Germany.
AD  - Chair of Epidemiology, University of Augsburg, University Hospital Augsburg, 
      Augsburg, Germany.
LA  - eng
GR  - 01VSF18013/Gemeinsamer Bundesausschuss/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20221123
PL  - England
TA  - Br J Clin Pharmacol
JT  - British journal of clinical pharmacology
JID - 7503323
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (Histamine H2 Antagonists)
SB  - IM
CIN - Br J Clin Pharmacol. 2023 Dec;89(12):3769-3770. PMID: 37731208
MH  - Humans
MH  - *Proton Pump Inhibitors/adverse effects
MH  - Prospective Studies
MH  - Bias
MH  - Histamine H2 Antagonists/adverse effects
MH  - *Dementia/chemically induced/epidemiology
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - cognitive impairment
OT  - dementia
OT  - proton pump inhibitors
EDAT- 2022/11/05 06:00
MHDA- 2023/01/18 06:00
CRDT- 2022/11/04 10:23
PHST- 2022/08/08 00:00 [revised]
PHST- 2022/03/07 00:00 [received]
PHST- 2022/10/25 00:00 [accepted]
PHST- 2022/11/05 06:00 [pubmed]
PHST- 2023/01/18 06:00 [medline]
PHST- 2022/11/04 10:23 [entrez]
AID - 10.1111/bcp.15583 [doi]
PST - ppublish
SO  - Br J Clin Pharmacol. 2023 Feb;89(2):602-616. doi: 10.1111/bcp.15583. Epub 2022 
      Nov 23.