PMID- 36334153
OWN - NLM
STAT- MEDLINE
DCOM- 20221108
LR  - 20231103
IS  - 1420-9071 (Electronic)
IS  - 1420-682X (Print)
IS  - 1420-682X (Linking)
VI  - 79
IP  - 11
DP  - 2022 Nov 5
TI  - Induction of pulmonary HLA-G expression by SARS-CoV-2 infection.
PG  - 582
LID - 10.1007/s00018-022-04592-9 [doi]
LID - 582
AB  - The non-classical human leukocyte antigen (HLA)-G exerts immune-suppressive 
      properties modulating both NK and T cell responses. While it is physiologically 
      expressed at the maternal-fetal interface and in immune-privileged organs, HLA-G 
      expression is found in tumors and in virus-infected cells. So far, there exists 
      little information about the role of HLA-G and its interplay with immune cells in 
      biopsies, surgical specimen or autopsy tissues of lung, kidney and/or heart 
      muscle from SARS-CoV-2-infected patients compared to control tissues. 
      Heterogeneous, but higher HLA-G protein expression levels were detected in lung 
      alveolar epithelial cells of SARS-CoV-2-infected patients compared to lung 
      epithelial cells from influenza-infected patients, but not in other organs or 
      lung epithelia from non-viral-infected patients, which was not accompanied by 
      high levels of SARS-CoV-2 nucleocapsid antigen and spike protein, but inversely 
      correlated to the HLA-G-specific miRNA expression. High HLA-G expression levels 
      not only in SARS-CoV-2-, but also in influenza-infected lung tissues were 
      associated with a high frequency of tissue-infiltrating immune cells, but low 
      numbers of CD8(+) cells and an altered expression of hyperactivation and 
      exhaustion markers in the lung epithelia combined with changes in the spatial 
      distribution of macrophages and T cells. Thus, our data provide evidence for an 
      involvement of HLA-G and HLA-G-specific miRNAs in immune escape and as suitable 
      therapeutic targets for the treatment of SARS-CoV-2 infections.
CI  - (c) 2022. The Author(s).
FAU - Seliger, Barbara
AU  - Seliger B
AUID- ORCID: 0000-0002-5544-4958
AD  - Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, 
      Magdeburger Str. 2, 06112, Halle (Saale), Germany. immunologie@uk-halle.de.
AD  - Fraunhofer Institute for Cell Therapy and Immunology, 04103, Leipzig, Germany. 
      immunologie@uk-halle.de.
AD  - Institute of Translational Immunology, Medical School "Theodor Fontane", 14770, 
      Brandenburg, Germany. immunologie@uk-halle.de.
FAU - Jasinski-Bergner, Simon
AU  - Jasinski-Bergner S
AD  - Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, 
      Magdeburger Str. 2, 06112, Halle (Saale), Germany.
FAU - Massa, Chiara
AU  - Massa C
AD  - Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, 
      Magdeburger Str. 2, 06112, Halle (Saale), Germany.
FAU - Mueller, Anja
AU  - Mueller A
AD  - Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, 
      Magdeburger Str. 2, 06112, Halle (Saale), Germany.
FAU - Biehl, Katharina
AU  - Biehl K
AD  - Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, 
      Magdeburger Str. 2, 06112, Halle (Saale), Germany.
FAU - Yang, Bo
AU  - Yang B
AD  - Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, 
      Magdeburger Str. 2, 06112, Halle (Saale), Germany.
FAU - Bachmann, Michael
AU  - Bachmann M
AD  - Helmholtz Zentrum Dresden-Rossendorf (HZDR), Institute of Radiopharmaceutical 
      Cancer Research, Dresden, Germany.
FAU - Jonigk, Danny
AU  - Jonigk D
AD  - Institute of Pathology, Hannover Medical School, 30625, Hannover, Germany.
AD  - German Center for Lung Research (DZL), Hannover Medical School (BREATH), 30625, 
      Hannover, Germany.
FAU - Eichhorn, Philip
AU  - Eichhorn P
AD  - Institute of Pathology, Friedrich-Alexander University, 91054, Erlangen, Germany.
FAU - Hartmann, Arndt
AU  - Hartmann A
AD  - Institute of Pathology, Friedrich-Alexander University, 91054, Erlangen, Germany.
FAU - Wickenhauser, Claudia
AU  - Wickenhauser C
AD  - Institute of Pathology, Martin Luther University Halle-Wittenberg, 06112, Halle 
      (Saale), Germany.
FAU - Bauer, Marcus
AU  - Bauer M
AD  - Institute of Pathology, Martin Luther University Halle-Wittenberg, 06112, Halle 
      (Saale), Germany.
LA  - eng
GR  - JA 3192/1-1/Deutsche Forschungsgemeinschaft/
GR  - 496182670/Deutsche Forschungsgemeinschaft/
GR  - 01KX2121/National University Medicine (NUM) network/
PT  - Journal Article
DEP - 20221105
PL  - Switzerland
TA  - Cell Mol Life Sci
JT  - Cellular and molecular life sciences : CMLS
JID - 9705402
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Humans
MH  - *COVID-19/genetics
MH  - SARS-CoV-2
MH  - HLA-G Antigens/genetics
MH  - *Influenza, Human/pathology
MH  - Lung/pathology
PMC - PMC9637071
OTO - NOTNLM
OT  - HLA-G
OT  - Immune cell infiltration
OT  - Immune response
OT  - SARS-CoV-2
OT  - microRNA
COIS- The authors have declared that they have no relevant financial or non-financial 
      interests to disclose.
EDAT- 2022/11/06 06:00
MHDA- 2022/11/09 06:00
PMCR- 2022/11/05
CRDT- 2022/11/05 12:25
PHST- 2022/07/19 00:00 [received]
PHST- 2022/10/07 00:00 [accepted]
PHST- 2022/10/05 00:00 [revised]
PHST- 2022/11/05 12:25 [entrez]
PHST- 2022/11/06 06:00 [pubmed]
PHST- 2022/11/09 06:00 [medline]
PHST- 2022/11/05 00:00 [pmc-release]
AID - 10.1007/s00018-022-04592-9 [pii]
AID - 4592 [pii]
AID - 10.1007/s00018-022-04592-9 [doi]
PST - epublish
SO  - Cell Mol Life Sci. 2022 Nov 5;79(11):582. doi: 10.1007/s00018-022-04592-9.