PMID- 36334459
OWN - NLM
STAT- MEDLINE
DCOM- 20221215
LR  - 20221220
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 170
DP  - 2022 Dec
TI  - Health threat of PM(2.5)-bound trace elements exposure on asthma hospital 
      admission: A time-stratified case-crossover study.
PG  - 107604
LID - S0160-4120(22)00531-1 [pii]
LID - 10.1016/j.envint.2022.107604 [doi]
AB  - Environmental pollution of trace elements has become of main concern due to the 
      adverse effects. To estimate the impact of PM(2.5)-bound trace elements on human 
      health, a time-stratified case-crossover study has been designed to examine the 
      short-term associations between 28 elements and asthma hospitalizations from 
      January 2019 to November 2021 in Xiamen, China. This research summarized the 
      major components that pose health risks in different seasons and took risk 
      assessment for different groups. We found that an inter-quartile range (IQR) 
      increase of Ca, Fe, Mn, Pd, Si, and Ti was positively associated with the 
      incidence of asthma in the lag of 0-4 days. In winter, the elements that 
      predisposed the population to asthma attack were the most, such as Al, Ba, Ca, 
      Cr, Cu, Fe, K, Mn, Pd, Si, and Ti, and these elements are at higher risk for 
      longer periods of time. The discrepancy in risk levels and major elements of 
      asthma diagnosis among various age groups were also found in this work. Our 
      results provided insights into the development of specific policies to reduce the 
      risk of asthma attacks due to exposure to PM(2.5)-bound trace elements.
CI  - Copyright (c) 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.
FAU - Wang, Yiyi
AU  - Wang Y
AD  - State Key Laboratory of Pollution Control and Resource Reuse, School of the 
      Environment, Nanjing University, Nanjing 210023, China.
FAU - Wu, Yangyang
AU  - Wu Y
AD  - State Key Laboratory of Pollution Control and Resource Reuse, School of the 
      Environment, Nanjing University, Nanjing 210023, China.
FAU - Zheng, Feixue
AU  - Zheng F
AD  - Aerosol and Haze Laboratory, Beijing Advanced Innovation Center for Soft Matter 
      Science and Engineering, Beijing University of Chemical Technology, Beijing, 
      100029, China.
FAU - Zhang, Ting
AU  - Zhang T
AD  - State Key Laboratory of Pollution Control and Resource Reuse, School of the 
      Environment, Nanjing University, Nanjing 210023, China.
FAU - Wang, Meng
AU  - Wang M
AD  - Department of Epidemiology and Environmental Health, School of Public Health and 
      Health Professions, University at Buffalo, Buffalo, NY, USA.
FAU - Huang, Lei
AU  - Huang L
AD  - State Key Laboratory of Pollution Control and Resource Reuse, School of the 
      Environment, Nanjing University, Nanjing 210023, China. Electronic address: 
      xlfan@iue.ac.cn.
FAU - Fan, Xiaolong
AU  - Fan X
AD  - Center for Excellence in Regional Atmospheric Environment, Institute of Urban 
      Environment, Chinese Academy of Sciences, Xiamen, China; Key Lab of Urban 
      Environment and Health, Institute of Urban Environment, Chinese Academy of 
      Sciences, Xiamen, China. Electronic address: huanglei@nju.edu.cn.
FAU - Chen, Jinsheng
AU  - Chen J
AD  - Center for Excellence in Regional Atmospheric Environment, Institute of Urban 
      Environment, Chinese Academy of Sciences, Xiamen, China; Key Lab of Urban 
      Environment and Health, Institute of Urban Environment, Chinese Academy of 
      Sciences, Xiamen, China.
FAU - Xiao, Naian
AU  - Xiao N
AD  - Department of Neurology, the First Affiliated Hospital of Xiamen University, 
      Xiamen, Fujian 361003, China.
LA  - eng
PT  - Journal Article
DEP - 20221028
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Trace Elements)
SB  - IM
MH  - Humans
MH  - Cross-Over Studies
MH  - *Trace Elements/toxicity
MH  - China/epidemiology
MH  - Hospitals
OTO - NOTNLM
OT  - Asthma hospitalization
OT  - PM(2.5)
OT  - Time-stratified
OT  - Trace element
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/11/06 06:00
MHDA- 2022/12/15 06:00
CRDT- 2022/11/05 19:17
PHST- 2022/08/08 00:00 [received]
PHST- 2022/10/11 00:00 [revised]
PHST- 2022/10/25 00:00 [accepted]
PHST- 2022/11/06 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/11/05 19:17 [entrez]
AID - S0160-4120(22)00531-1 [pii]
AID - 10.1016/j.envint.2022.107604 [doi]
PST - ppublish
SO  - Environ Int. 2022 Dec;170:107604. doi: 10.1016/j.envint.2022.107604. Epub 2022 
      Oct 28.