PMID- 36335222
OWN - NLM
STAT- MEDLINE
DCOM- 20230110
LR  - 20230111
IS  - 1744-313X (Electronic)
IS  - 1744-3121 (Linking)
VI  - 50
IP  - 1
DP  - 2023 Feb
TI  - Association between the interleukin-1B polymorphism at rs16944 T>C and diabetic 
      retinopathy.
PG  - 34-40
LID - 10.1111/iji.12604 [doi]
AB  - Diabetic retinopathy (DR) is a common microvascular complication of diabetes and 
      the leading cause of blindness at working age. DR is considered to be a chronic 
      low-grade inflammatory subclinical disease, and its pathogenesis is related to 
      genetic and environmental factors. Interleukin (IL)-1 is an important 
      inflammatory cytokine. An association between DR and the rs16944 (IL-1B-511) T>C 
      gene polymorphism has not been reported. The aim of this study was to investigate 
      the association between the rs16944 T>C gene polymorphism and DR in the Han 
      population in southwest China. Participants in this study were 272 patients with 
      DR, 274 patients with type 2 diabetes mellitus (T2DM), and 335 healthy controls 
      (NC). The polymerase chain reaction-restriction fragment length polymorphism 
      method was used to detect the rs16944 T>C genotype of participants. The 
      distribution frequencies of the rs16944 T>C genotype and allele were 
      significantly different among the three groups (p < .05). The distribution 
      frequency of TT, CT, CC genotype (chi(2) = 9.893, p = .007; chi(2) = 6.567, p = .037) 
      and each allele (chi(2) = 5.585, p = .018; chi(2) = 9.187, p = .002) in the DR group 
      was significantly different from the NC and T2DM groups, respectively. Logistic 
      regression analysis showed that the TT + CT genotype was a risk factor for DR, 
      with an odds ratio of 1.731 (95% confidence interval 1.140-2.627, p = .01). The 
      rs16944 T>C gene polymorphism may be associated with DR, and the TT+CT genotype 
      may increase the risk of DR.
CI  - (c) 2022 John Wiley & Sons Ltd.
FAU - Lin, Nengbo
AU  - Lin N
AD  - Department of Endocrinology, Luzhou People's Hospital, Luzhou, China.
FAU - Lu, Hua
AU  - Lu H
AD  - Department of Nephrology, Luzhou People's Hospital, Luzhou, China.
FAU - Cheng, Xiaoling
AU  - Cheng X
AD  - Department of Endocrinology, Luohu People's Hospital, Shenzhen, China.
FAU - Zhao, Ya
AU  - Zhao Y
AD  - Department of Endocrinology, Chengdu Pidu District Hospital of Traditional 
      Chinese Medicine, Chengdu, China.
FAU - Wan, Qin
AU  - Wan Q
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, China.
FAU - Luo, Yi
AU  - Luo Y
AD  - Department of Endocrinology, Luzhou People's Hospital, Luzhou, China.
FAU - Miao, Ying
AU  - Miao Y
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, China.
FAU - Bai, Xue
AU  - Bai X
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, China.
FAU - Liu, Dan
AU  - Liu D
AD  - Department of Endocrinology, Pengzhou People's Hospital, Pengzhou, China.
FAU - Wang, Chao
AU  - Wang C
AD  - Department of Ophthalmology, the Neijiang First People's Hospital, Neijiang, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20221105
PL  - England
TA  - Int J Immunogenet
JT  - International journal of immunogenetics
JID - 101232337
RN  - 0 (Interleukins)
RN  - 0 (Interleukin-1)
SB  - IM
MH  - Humans
MH  - Gene Frequency
MH  - *Diabetes Mellitus, Type 2/complications/genetics
MH  - *Diabetic Retinopathy/genetics/complications
MH  - Polymorphism, Genetic
MH  - Genotype
MH  - Interleukins/genetics
MH  - Interleukin-1/genetics
MH  - Polymorphism, Single Nucleotide
MH  - Case-Control Studies
MH  - Genetic Predisposition to Disease
OTO - NOTNLM
OT  - IL-1B
OT  - diabetic retinopathy
OT  - genotype
EDAT- 2022/11/06 06:00
MHDA- 2023/01/11 06:00
CRDT- 2022/11/06 00:41
PHST- 2022/09/22 00:00 [revised]
PHST- 2022/05/27 00:00 [received]
PHST- 2022/10/16 00:00 [accepted]
PHST- 2022/11/06 06:00 [pubmed]
PHST- 2023/01/11 06:00 [medline]
PHST- 2022/11/06 00:41 [entrez]
AID - 10.1111/iji.12604 [doi]
PST - ppublish
SO  - Int J Immunogenet. 2023 Feb;50(1):34-40. doi: 10.1111/iji.12604. Epub 2022 Nov 5.