PMID- 36335543
OWN - NLM
STAT- MEDLINE
DCOM- 20230224
LR  - 20230224
IS  - 1436-6215 (Electronic)
IS  - 1436-6207 (Print)
IS  - 1436-6207 (Linking)
VI  - 62
IP  - 2
DP  - 2023 Mar
TI  - Intake of prebiotic fibers and the risk of laryngeal cancer: the PrebiotiCa 
      study.
PG  - 977-985
LID - 10.1007/s00394-022-03030-7 [doi]
AB  - PURPOSE: To evaluate whether the intake of specific fibers with prebiotic 
      activity, e.g., inulin-type fructans (ITFs), fructo-oligosaccharides (FOSs), and 
      galacto-oligosaccharides (GOSs), is associated with laryngeal cancer risk. 
      METHODS: Within the PrebiotiCa study, we used data from a case-control study 
      (Italy, 1992-2009) with 689 incident, histologically confirmed laryngeal cancer 
      cases and 1605 controls. Six prebiotic molecules (ITFs, nystose [FOS], kestose 
      [FOS], 1F-beta-fructofuranosylnystose [FOS], raffinose [GOS] and stachyose [GOS]) 
      were quantified in various foods via ad hoc conducted laboratory analyses. 
      Subjects' prebiotic fiber intake was calculated by multiplying food frequency 
      questionnaire intake by the prebiotic content of each food item. The odds ratios 
      (OR) of laryngeal cancer for prebiotic fiber intake were calculated using 
      logistic regression models, including, among others, terms for tobacco, alcohol, 
      and total energy intake. RESULTS: The intakes of kestose, raffinose and stachyose 
      were inversely associated with laryngeal cancer, with ORs for the highest versus 
      the lowest quartile of 0.70 (95% confidence interval, CI 0.50-0.99) for kestose, 
      0.65 (95% CI 0.45-0.93) for raffinose and 0.61 (95% CI 0.45-0.83) for stachyose. 
      ITFs, nystose and 1F-beta-fructofuranosylnystose were not associated with laryngeal 
      cancer risk. Current smokers and heavy drinkers with medium-low intakes of such 
      prebiotic fibers had, respectively, an over 15-fold increased risk versus never 
      smokers with medium-high intakes and a five to sevenfold increased risk versus 
      never/moderate drinkers with medium-high intakes. CONCLUSION: Although 
      disentangling the effects of the various components of fiber-rich foods is 
      complex, our results support a favorable role of selected prebiotic fibers on 
      laryngeal cancers risk.
CI  - (c) 2022. The Author(s).
FAU - Turati, Federica
AU  - Turati F
AUID- ORCID: 0000-0002-5841-5773
AD  - Unit of Medical Statistics and Biometry, IRCCS National Cancer Institute of 
      Milan, Milan, Italy. federica.turati@unimi.it.
AD  - Department of Clinical Sciences and Community Health, University of Milan, Via G. 
      Celoria, 22, 20133, Milan, Italy. federica.turati@unimi.it.
FAU - Concina, Federica
AU  - Concina F
AD  - Clinical Epidemiology and Public Health Research Unit, Institute for Maternal and 
      Child Health-IRCCS "Burlo Garofolo", Trieste, Italy.
FAU - Bertuccio, Paola
AU  - Bertuccio P
AD  - Department of Clinical Sciences and Community Health, University of Milan, Via G. 
      Celoria, 22, 20133, Milan, Italy.
AD  - Department of Public Health, Experimental and Forensic Medicine, University of 
      Pavia, Pavia, Italy.
FAU - Fiori, Federica
AU  - Fiori F
AD  - Department of Medicine, University of Udine, Udine, Italy.
FAU - Parpinel, Maria
AU  - Parpinel M
AD  - Department of Medicine, University of Udine, Udine, Italy.
FAU - Taborelli, Martina
AU  - Taborelli M
AD  - Unit of Cancer Epidemiology, CRO Aviano National Cancer Institute, IRCCS, Aviano, 
      Italy.
FAU - Rosato, Valentina
AU  - Rosato V
AD  - Unit of Medical Statistics and Biometry, IRCCS National Cancer Institute of 
      Milan, Milan, Italy.
FAU - Garavello, Werner
AU  - Garavello W
AD  - Department of Otorhinolaryngology, School of Medicine and Surgery, University of 
      Milano- Bicocca, Monza, Italy.
FAU - Negri, Eva
AU  - Negri E
AUID- ORCID: 0000-0001-9712-8526
AD  - Department of Medical and Surgical Sciences, University of Bologna, Bologna, 
      Italy.
FAU - La Vecchia, Carlo
AU  - La Vecchia C
AD  - Department of Clinical Sciences and Community Health, University of Milan, Via G. 
      Celoria, 22, 20133, Milan, Italy.
LA  - eng
GR  - Ricerca Finalizzata Giovani Ricercatori/Ministero della Salute/
GR  - GR-2016-02361123/Ministero della Salute/
PT  - Journal Article
DEP - 20221106
PL  - Germany
TA  - Eur J Nutr
JT  - European journal of nutrition
JID - 100888704
RN  - N5O3QU595M (Raffinose)
RN  - 0 (Oligosaccharides)
RN  - 9005-80-5 (Inulin)
RN  - 0 (Fructans)
RN  - 0 (Prebiotics)
SB  - IM
MH  - Humans
MH  - Raffinose
MH  - *Laryngeal Neoplasms
MH  - Case-Control Studies
MH  - Oligosaccharides
MH  - Inulin
MH  - Fructans
MH  - Prebiotics
PMC - PMC9941254
OTO - NOTNLM
OT  - Diet
OT  - Fiber
OT  - Laryngeal cancer
OT  - Prebiotics
OT  - Prevention
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/11/07 06:00
MHDA- 2023/02/25 06:00
PMCR- 2022/11/06
CRDT- 2022/11/06 14:02
PHST- 2022/04/12 00:00 [received]
PHST- 2022/10/05 00:00 [accepted]
PHST- 2022/11/07 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2022/11/06 14:02 [entrez]
PHST- 2022/11/06 00:00 [pmc-release]
AID - 10.1007/s00394-022-03030-7 [pii]
AID - 3030 [pii]
AID - 10.1007/s00394-022-03030-7 [doi]
PST - ppublish
SO  - Eur J Nutr. 2023 Mar;62(2):977-985. doi: 10.1007/s00394-022-03030-7. Epub 2022 
      Nov 6.