PMID- 36336051
OWN - NLM
STAT- MEDLINE
DCOM- 20221206
LR  - 20221206
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 858
IP  - Pt 2
DP  - 2023 Feb 1
TI  - Associations between exposure to brominated flame retardants and metabolic 
      syndrome and its components in U.S. adults.
PG  - 159935
LID - S0048-9697(22)07035-8 [pii]
LID - 10.1016/j.scitotenv.2022.159935 [doi]
AB  - BACKGROUND: Humans are simultaneously exposed to numerous of environmental 
      brominated flame retardants (BFRs). We aim to explore the overall associations of 
      BFRs mixture on metabolic syndrome (MetS) and its components and further identify 
      significant chemicals. METHODS: This study included 4641 adults from the National 
      Health and Nutrition Examination Survey (NHANES) in 2007-2016. The weighted 
      logistic regression was conducted to estimate the association of a single BFR 
      exposure with MetS and its components. Meanwhile, the weighted quantile sum (WQS) 
      regression and Bayesian kernel machine regression (BKMR) were adopted to evaluate 
      the overall associations of BFRs mixture on MetS and its components, and to 
      identify significant chemicals. We also evaluated potential associations modified 
      by sex. RESULTS: In the weighted logistic regression model, PBB153 were 
      positively associated with MetS in a dose-dependent manner (P(trend) < 0.05). For 
      its components, increasing quartiles of most BFRs were positively associated with 
      abdominal obesity, hypertriglyceridemia, and low HDL. However, we found no 
      statistically significant associations between BFRs and hypertension and 
      hyperglycemia. WQS analyses found that BFRs mixture was positively associated 
      with MetS (OR: 1.30; 95%CI:1.14, 1.46), abdominal obesity (OR: 1.15; 95%CI:1.03, 
      1.27), hypertriglyceridemia (OR:1.43; 95%CI:1.19, 1.67), and low HDL (OR: 1.15; 
      95%CI:1.01, 1.29). BKMR showed associations in a similar direction as WQS for 
      BFRs mixture. For MetS, hypertriglyceridemia and Low HDL, PBB153, PBDE28 and 
      PBDE209 were the most heavily weighting chemicals and had the highest the 
      posterior inclusion probabilities in the WQS and BKMR, respectively. BFRs showed 
      stronger associations of MetS and its components in males than in females. 
      CONCLUSIONS: The present study suggested exposure to BFRs mixture was positively 
      associated with MetS and its components in adults, and PBB153, PBDE28 and PBDE209 
      were the significant chemicals. However, prospective cohort studies are still 
      needed to confirm the causal effect between BFRs mixture and MetS.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Che, Zhiqiang
AU  - Che Z
AD  - Department of Biostatistics, School of Public Health, Cheeloo College of 
      Medicine, Shandong University, Jinan, Shandong 250012, China.
FAU - Jia, Huixun
AU  - Jia H
AD  - School of Public Health, Fudan University, Shanghai, China; National Clinical 
      Research Center for Ophthalmic Diseases, Shanghai, China; Department of 
      Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), 
      Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
FAU - Chen, Renjie
AU  - Chen R
AD  - School of Public Health, Fudan University, Shanghai, China.
FAU - Pan, Keyu
AU  - Pan K
AD  - Department of Biostatistics, School of Public Health, Cheeloo College of 
      Medicine, Shandong University, Jinan, Shandong 250012, China.
FAU - Fan, Zhe
AU  - Fan Z
AD  - Department of Biostatistics, School of Public Health, Cheeloo College of 
      Medicine, Shandong University, Jinan, Shandong 250012, China.
FAU - Su, Chang
AU  - Su C
AD  - National Institute for Nutrition and Health, Chinese Center for Disease Control 
      and Prevention/Key Laboratory of Trace Element Nutrition of National Health 
      Commission, Beijing 100050, 29 Nanwei Road, Xicheng District, Beijing, China. 
      Electronic address: suchang@ninh.chinacdc.cn.
FAU - Wu, Zhenyu
AU  - Wu Z
AD  - School of Public Health, Fudan University, Shanghai, China. Electronic address: 
      zyw@fudan.edu.cn.
FAU - Zhang, Tao
AU  - Zhang T
AD  - Department of Biostatistics, School of Public Health, Cheeloo College of 
      Medicine, Shandong University, Jinan, Shandong 250012, China. Electronic address: 
      taozhang@sdu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20221103
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Flame Retardants)
RN  - 9S2PWX7KBN (2,4,5,2',4',5'-hexabromobiphenyl)
RN  - 0 (Hydrocarbons, Brominated)
SB  - IM
MH  - Male
MH  - Adult
MH  - Female
MH  - Humans
MH  - *Flame Retardants/analysis
MH  - Nutrition Surveys
MH  - Bayes Theorem
MH  - *Metabolic Syndrome/chemically induced/epidemiology
MH  - Environmental Exposure/analysis
MH  - Obesity, Abdominal
MH  - Prospective Studies
MH  - Obesity
MH  - *Hypertriglyceridemia
MH  - *Hydrocarbons, Brominated
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Brominated flame retardants
OT  - Chemical mixture exposure
OT  - Metabolic syndrome
OT  - Weighted quantile sum regression
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/11/07 06:00
MHDA- 2022/12/07 06:00
CRDT- 2022/11/06 19:33
PHST- 2022/07/19 00:00 [received]
PHST- 2022/10/06 00:00 [revised]
PHST- 2022/10/30 00:00 [accepted]
PHST- 2022/11/07 06:00 [pubmed]
PHST- 2022/12/07 06:00 [medline]
PHST- 2022/11/06 19:33 [entrez]
AID - S0048-9697(22)07035-8 [pii]
AID - 10.1016/j.scitotenv.2022.159935 [doi]
PST - ppublish
SO  - Sci Total Environ. 2023 Feb 1;858(Pt 2):159935. doi: 
      10.1016/j.scitotenv.2022.159935. Epub 2022 Nov 3.