PMID- 36338327
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221108
IS  - 2574-0970 (Electronic)
IS  - 2574-0970 (Linking)
VI  - 5
IP  - 10
DP  - 2022 Oct 28
TI  - Glycopolymer-Functionalized MOF-808 Nanoparticles as a Cancer-Targeted Dual Drug 
      Delivery System for Carboplatin and Floxuridine.
PG  - 13862-13873
LID - 10.1021/acsanm.2c01632 [doi]
AB  - Codelivery of chemotherapeutics via nanomaterials has attracted much attention 
      over the last decades due to improved drug delivery to tumor tissues, decreased 
      systemic effects, and increased therapeutic efficacies. High porosities, large 
      pore volumes and surface areas, and tunable structures have positioned 
      metal-organic frameworks (MOFs) as promising drug delivery systems (DDSs). In 
      particular, nanoscale Zr-linked MOFs such as MOF-808 offer notable advantages for 
      biomedical applications such as high porosity, good stability, and 
      biocompatibility. In this study, we report efficient dual drug delivery of 
      floxuridine (FUDR) and carboplatin (CARB) loaded in MOF-808 nanoparticles to 
      cancer cells. The nanoparticles were further functionalized by a poly(acrylic 
      acid-mannose acrylamide) (PAAMAM) glycopolymer coating to obtain a highly 
      selective DDS in cancer cells and enhance the therapeutic efficacy of 
      chemotherapy. While MOF-808 was found to enhance the individual therapeutic 
      effects of FUDR and CARB toward cancerous cells, combining FUDR and CARB was seen 
      to cause a synergistic effect, further enhancing the cytotoxicity of the free 
      drugs. Enhancement of CARB loading and therefore cytotoxicity of the CARB-loaded 
      MOFs could be induced through a modified activation protocol, while coating of 
      MOF-808 with the PAAMAM glycopolymer increased the uptake of the nanoparticles in 
      cancer cells used in the study and offered a particularly significant selective 
      drug delivery with high cytotoxicity in HepG2 human hepatocellular carcinoma 
      cells. These results show how the enhancement of cytotoxicity is possible through 
      both nanovector delivery and synergistic treatment, and that MOF-808 is a viable 
      candidate for future drug delivery studies.
CI  - (c) 2022 The Authors. Published by American Chemical Society.
FAU - Demir Duman, Fatma
AU  - Demir Duman F
AD  - WestCHEM, School of Chemistry, University of Glasgow, University Avenue, Glasgow 
      G12 8QQ, U.K.
FAU - Monaco, Alessandra
AU  - Monaco A
AD  - Department of Chemistry, University of Warwick, CV4 7AL Coventry, U.K.
FAU - Foulkes, Rachel
AU  - Foulkes R
AD  - WestCHEM, School of Chemistry, University of Glasgow, University Avenue, Glasgow 
      G12 8QQ, U.K.
FAU - Becer, C Remzi
AU  - Becer CR
AUID- ORCID: 0000-0003-0968-6662
AD  - Department of Chemistry, University of Warwick, CV4 7AL Coventry, U.K.
FAU - Forgan, Ross S
AU  - Forgan RS
AUID- ORCID: 0000-0003-4767-6852
AD  - WestCHEM, School of Chemistry, University of Glasgow, University Avenue, Glasgow 
      G12 8QQ, U.K.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220622
PL  - United States
TA  - ACS Appl Nano Mater
JT  - ACS applied nano materials
JID - 101726750
PMC - PMC9623548
COIS- The authors declare no competing financial interest.
EDAT- 2022/11/08 06:00
MHDA- 2022/11/08 06:01
PMCR- 2022/11/01
CRDT- 2022/11/07 04:26
PHST- 2022/11/07 04:26 [entrez]
PHST- 2022/11/08 06:00 [pubmed]
PHST- 2022/11/08 06:01 [medline]
PHST- 2022/11/01 00:00 [pmc-release]
AID - 10.1021/acsanm.2c01632 [doi]
PST - ppublish
SO  - ACS Appl Nano Mater. 2022 Oct 28;5(10):13862-13873. doi: 10.1021/acsanm.2c01632. 
      Epub 2022 Jun 22.