PMID- 36339437
OWN - NLM
STAT- MEDLINE
DCOM- 20221108
LR  - 20221110
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - Triglyceride-glucose index in the prediction of major adverse cardiovascular 
      events in patients with type 2 diabetes mellitus after coronary artery bypass 
      surgery: A retrospective cohort study.
PG  - 1015747
LID - 10.3389/fendo.2022.1015747 [doi]
LID - 1015747
AB  - BACKGROUND: Insulin resistance (IR) is a significant risk factor for 
      cardiometabolic diseases and a defining feature of type 2 diabetes mellitus 
      (T2DM). This study aimed to examine the potential value of triglyceride-glucose 
      (TyG) index as a predictor of prognosis in coronary heart disease (CHD) patients 
      with T2DM after coronary artery bypass grafting (CABG) surgery and to facilitate 
      the identification of those at high risk of major adverse cardiovascular events 
      (MACEs) for closer monitoring or possible early intervention. METHODS: This study 
      enrolled 386 T2DM patients who underwent CABG surgery at Nanjing Drum Tower 
      Hospital. Patients were separated into two groups according to the median 
      preoperative TyG Index. The Kaplan-Meier plot was used to compare the rate of 
      MACEs-free survival in T2DM patients after CABG. The independent risk factors for 
      the occurrence of MACEs were investigated using multivariate analysis. Nomogram 
      was used to depict the predictive model. RESULTS: Significantly more MACEs 
      occurred in individuals with higher medians of the TyG index (65 (33.7%) vs. 39 
      (20.2%), p=0.003). TyG index [hazard ratio (HR) 12.926], LVEF [hazard ratio (HR) 
      0.916], and NYHA functional class III/IV [hazard ratio (HR) 4.331] were 
      identified as independent predictors of MACEs incidence in post-CABG T2DM 
      patients by multivariate analysis. The area under the curve (AUC) for predicting 
      MACEs using the TyG index was 0.89 at five years. Combining the TyG index, LVEF, 
      and NYHA functional class III/IV to build a novel risk assessment model for 
      postoperative MACEs, the AUC climbed to 0.93 at five years. With AUCs, the 
      nomogram comprised of the TyG index, LVEF, and NYHA functional class III/IV 
      demonstrated strong specificity in the training and test sets. CONCLUSIONS: The 
      incidence of MACEs is high among post-CABG T2DM patients with a high TyG index. 
      TyG index improves the diagnostic accuracy of MACEs, especially at long-term 
      follow-up. A high TyG index may serve as an early warning signal for individuals 
      to undertake lifestyle adjustments that can reduce the progression or incidence 
      of MACEs.
CI  - Copyright (c) 2022 Zhang, Chong, Li, Li, Zhang, Xue and Wang.
FAU - Zhang, He
AU  - Zhang H
AD  - Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, Chinese 
      Academy of Medical Sciences& Peking Union Medical College, Graduate School of 
      Peking Union Medical College, Nanjing, China.
FAU - Chong, Hoshun
AU  - Chong H
AD  - Department of Cardiothoracic Surgery, The Affiliated Drum Tower Hospital of 
      Nanjing University Medical School, Nanjing, China.
FAU - Li, Zeshi
AU  - Li Z
AD  - Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, Chinese 
      Academy of Medical Sciences& Peking Union Medical College, Graduate School of 
      Peking Union Medical College, Nanjing, China.
FAU - Li, Kai
AU  - Li K
AD  - Department of Cardiothoracic Surgery, The Affiliated Drum Tower Hospital of 
      Nanjing University Medical School, Nanjing, China.
FAU - Zhang, Bomin
AU  - Zhang B
AD  - Department of Cardiothoracic Surgery, The Affiliated Drum Tower Hospital of 
      Nanjing University Medical School, Nanjing, China.
FAU - Xue, Yunxing
AU  - Xue Y
AD  - Department of Cardiothoracic Surgery, The Affiliated Drum Tower Hospital of 
      Nanjing University Medical School, Nanjing, China.
FAU - Wang, Dongjin
AU  - Wang D
AD  - Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, Chinese 
      Academy of Medical Sciences& Peking Union Medical College, Graduate School of 
      Peking Union Medical College, Nanjing, China.
AD  - Department of Cardiothoracic Surgery, The Affiliated Drum Tower Hospital of 
      Nanjing University Medical School, Nanjing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221020
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Triglycerides)
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Blood Glucose)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Triglycerides
MH  - *Diabetes Mellitus, Type 2/diagnosis
MH  - Glucose
MH  - Blood Glucose
MH  - Retrospective Studies
MH  - Biomarkers
MH  - Coronary Artery Bypass/adverse effects
MH  - *Cardiovascular Diseases
PMC - PMC9630944
OTO - NOTNLM
OT  - coronary artery bypass grafting
OT  - major adverse cardiovascular events
OT  - nomogram model
OT  - triglyceride-glucose index
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/08 06:00
MHDA- 2022/11/09 06:00
PMCR- 2022/10/20
CRDT- 2022/11/07 04:45
PHST- 2022/08/10 00:00 [received]
PHST- 2022/10/10 00:00 [accepted]
PHST- 2022/11/07 04:45 [entrez]
PHST- 2022/11/08 06:00 [pubmed]
PHST- 2022/11/09 06:00 [medline]
PHST- 2022/10/20 00:00 [pmc-release]
AID - 10.3389/fendo.2022.1015747 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Oct 20;13:1015747. doi: 
      10.3389/fendo.2022.1015747. eCollection 2022.