PMID- 36340791
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231103
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 16
DP  - 2022
TI  - Functional connectivity impairment of thalamus-cerebellum-scratching neural 
      circuits in pruritus of chronic spontaneous urticaria.
PG  - 1026200
LID - 10.3389/fnins.2022.1026200 [doi]
LID - 1026200
AB  - Pruritus of chronic spontaneous urticaria (CSU) is one of the most common and 
      irritating sensations that severely affects the quality of life. However, the 
      changes in the functional connectivity (FC) between thalamic subregions and other 
      brain regions have not been fully elucidated. This study aimed to explore the 
      potential changes in brain neural circuits by focusing on various subregions of 
      the thalamus in patients with CSU pruritus to contribute to the understanding of 
      chronic pruritus from the perspective of central mechanisms. A total of 56 
      patients with CSU and 30 healthy controls (HCs) completed the data analysis. 
      Urticaria Activity Score 7 (UAS7), pruritus visual analog score (VAS-P), 
      Dermatological Life Quality Index (DLQI), and immunoglobulin E (IgE) values were 
      collected to assess clinical symptoms. Seed-based resting-state functional 
      connectivity (rs-FC) analysis was used to assess relevant changes in the neural 
      circuits of the brain. Compared to HCs, seeds within the caudal temporal thalamus 
      (cTtha) on the right side of patients with CSU showed increased rs-FC with the 
      cerebellum anterior lobe (CAL). Seeds within the lateral prefrontal thalamus 
      (lPFtha) on the right side showed increased rs-FC with both CAL and pons, while 
      those within the medial prefrontal thalamus (mPFtha) on the right side showed 
      increased rs-FC with both CAL and the dorsal lateral prefrontal cortex (dlPFC) on 
      the right side. Seeds within the posterior parietal thalamus (PPtha) on the right 
      side showed increased rs-FC with the cerebellum posterior lobe (CPL) on the left 
      side. The UAS7 values and IgE levels were positively correlated with the rs-FC of 
      the right dlPFC. Our results suggest that patients with CSU may exhibit stronger 
      rs-FC alterations between certain thalamic subregions and other brain regions. 
      These changes affect areas of the brain involved in sensorimotor and scratching. 
      TRIAL REGISTRATION NUMBER: [http://www.chictr.org.cn], identifier 
      [ChiCTR1900022994].
CI  - Copyright (c) 2022 Zhang, Zou, Yu, Xiao, Shi, Cao, Liu, Zheng, Zheng, Zhou, Yao, 
      Deng, Yang, Chen, Hao, Li and Li.
FAU - Zhang, Leixiao
AU  - Zhang L
AD  - Department of Integrated Traditional and Western Medicine, West China Hospital, 
      Sichuan University, Chengdu, Sichuan, China.
FAU - Zou, Zihao
AU  - Zou Z
AD  - Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, Sichuan, China.
FAU - Yu, Siyi
AU  - Yu S
AD  - Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, Sichuan, China.
FAU - Xiao, Xianjun
AU  - Xiao X
AD  - College of Health Rehabilitation, Chengdu University of Traditional Chinese 
      Medicine, Chengdu, Sichuan, China.
FAU - Shi, Yunzhou
AU  - Shi Y
AD  - Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, Sichuan, China.
FAU - Cao, Wei
AU  - Cao W
AD  - Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, Sichuan, China.
FAU - Liu, Ying
AU  - Liu Y
AD  - Chinese Medicine Hospital, Chengdu, Sichuan, China.
FAU - Zheng, Hui
AU  - Zheng H
AD  - Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, Sichuan, China.
FAU - Zheng, Qianhua
AU  - Zheng Q
AD  - Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, Sichuan, China.
FAU - Zhou, Siyuan
AU  - Zhou S
AD  - Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, Sichuan, China.
FAU - Yao, Junpeng
AU  - Yao J
AD  - Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, Sichuan, China.
FAU - Deng, Yanli
AU  - Deng Y
AD  - Sichuan Second Chinese Medicine Hospital, Chengdu, Sichuan, China.
FAU - Yang, Qian
AU  - Yang Q
AD  - Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, Sichuan, China.
FAU - Chen, Sijue
AU  - Chen S
AD  - Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, Sichuan, China.
FAU - Hao, Pingsheng
AU  - Hao P
AD  - Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 
      China.
FAU - Li, Ning
AU  - Li N
AD  - Department of Integrated Traditional and Western Medicine, West China Hospital, 
      Sichuan University, Chengdu, Sichuan, China.
FAU - Li, Ying
AU  - Li Y
AD  - Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, Sichuan, China.
LA  - eng
PT  - Journal Article
DEP - 20221020
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC9630740
OTO - NOTNLM
OT  - cerebellum
OT  - chronic spontaneous urticaria
OT  - functional connectivity
OT  - pruritus
OT  - scratching
OT  - thalamus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/08 06:00
MHDA- 2022/11/08 06:01
PMCR- 2022/01/01
CRDT- 2022/11/07 05:06
PHST- 2022/08/23 00:00 [received]
PHST- 2022/10/06 00:00 [accepted]
PHST- 2022/11/07 05:06 [entrez]
PHST- 2022/11/08 06:00 [pubmed]
PHST- 2022/11/08 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2022.1026200 [doi]
PST - epublish
SO  - Front Neurosci. 2022 Oct 20;16:1026200. doi: 10.3389/fnins.2022.1026200. 
      eCollection 2022.