PMID- 36341093
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221108
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 13
DP  - 2022
TI  - Two-dimensional ultrasound and two-dimensional shear wave elastography on femoral 
      and saphenous neuropathy in patients with type 2 diabetes mellitus.
PG  - 996199
LID - 10.3389/fneur.2022.996199 [doi]
LID - 996199
AB  - OBJECTIVE: This study aims to examine the value of two-dimensional (2D) 
      ultrasound and two-dimensional shear wave elastography (2D-SWE) in evaluating 
      femoral nerve (FN) and saphenous nerve (SN) neuropathy in patients with type 2 
      diabetes mellitus (T2DM). MATERIALS AND METHODS: According to the diabetic 
      peripheral neuropathy (DPN) diagnostic criteria, 60 patients with T2DM were 
      enrolled and divided into 35 T2DM patients without DPN (non-DPN group) and 25 
      T2DM patients with DPN (DPN group). The control group consisted of another 15 
      healthy volunteers. The width, thickness, cross-sectional area (CSA), and 
      perimeter of the FN and SN in the lower extremities were measured with 2D 
      ultrasound. The average shear wave velocity (SWV) of the FN and SN was measured 
      by 2D-SWE. Parameters of the left and right lower extremities were compared in 
      each group, and the above parameters were compared among groups. The correlations 
      between ultrasonographic and laboratory parameters were evaluated, and the 
      independent influencing factors of SWV of the FN and SN were analyzed. RESULTS: 
      The width, thickness, CSA, perimeter, and SWV of FN and SN in the DPN group were 
      greater than those in the non-DPN groups and control group (P < 0.05). The width, 
      thickness, CSA, perimeter, and SWV of the FN and SN in the non-DPN group were 
      greater than those in the control group (P < 0.05). The CSA of FN was positively 
      correlated with FPG, HbA1c, and TG (r = 0.34-0.69, P < 0.01). The perimeter of FN 
      was positively correlated with FPG, HbA1c, and TG (r = 0.37-0.68, P < 0.01). The 
      perimeter of the FN was negatively correlated with IgF-1 (r = -0.31, P < 0.05). 
      The CSA of the SN was positively correlated with FPG and TG (r = 0.26-0.42, P < 
      0.05). The perimeter of the SN was positively correlated with FPG and TG (r = 
      0.37-0.39, P < 0.01). The SWV of FN and SN were positively correlated with FPG 
      and TG (r = 0.35-0.57, P < 0.01; r = 0.43-0.49, P < 0.01). FPG and TG were 
      independent influencing factors of the SWV of the FN and SN (P < 0.05). 
      CONCLUSION: 2D ultrasound and 2D-SWE could be used to non-invasively, 
      objectively, and accurately evaluate the abnormal changes of the FN and SN in 
      patients with T2DM. It has important clinical significance for the early 
      diagnosis of DPN and the curative effect evaluation.
CI  - Copyright (c) 2022 Song, Zhang, Zhang and Hu.
FAU - Song, Yang
AU  - Song Y
AD  - Department of Diagnostic Ultrasound, The Second Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Zhang, Ying
AU  - Zhang Y
AD  - Department of Diagnostic Ultrasound, Xinhua Affiliated Hospital of Dalian 
      University, Dalian, China.
FAU - Zhang, Yuhong
AU  - Zhang Y
AD  - Department of Diagnostic Ultrasound, The Second Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Hu, Bin
AU  - Hu B
AD  - Department of Diagnostic Ultrasound, The Second Hospital of Dalian Medical 
      University, Dalian, China.
LA  - eng
PT  - Journal Article
DEP - 20221021
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC9634548
OTO - NOTNLM
OT  - diabetes
OT  - diagnosis
OT  - elasticity imaging technique
OT  - femoral nerve
OT  - peripheral neuropathy
OT  - saphenous nerve
OT  - type 2
OT  - ultrasonography
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/08 06:00
MHDA- 2022/11/08 06:01
PMCR- 2022/10/21
CRDT- 2022/11/07 05:12
PHST- 2022/07/17 00:00 [received]
PHST- 2022/10/03 00:00 [accepted]
PHST- 2022/11/07 05:12 [entrez]
PHST- 2022/11/08 06:00 [pubmed]
PHST- 2022/11/08 06:01 [medline]
PHST- 2022/10/21 00:00 [pmc-release]
AID - 10.3389/fneur.2022.996199 [doi]
PST - epublish
SO  - Front Neurol. 2022 Oct 21;13:996199. doi: 10.3389/fneur.2022.996199. eCollection 
      2022.