PMID- 36341407
OWN - NLM
STAT- MEDLINE
DCOM- 20221108
LR  - 20221222
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 13
DP  - 2022
TI  - Strongyloidiasis stercoralis coinfection is associated with altered iron status 
      biomarkers in tuberculous lymphadenitis.
PG  - 999614
LID - 10.3389/fimmu.2022.999614 [doi]
LID - 999614
AB  - Soil-transmitted helminth [mainly Strongyloidiasis stercoralis (Ss)] and 
      tuberculous lymphadenitis (TBL) coinfection in humans is a significant public 
      health problem. We have previously shown that TBL+Ss+ coinfection significantly 
      alters diverse cytokine, matrix metalloproteinase, and tissue inhibitors of 
      metalloproteinase profiles. However, no data is available to understand the 
      influence of Ss coinfection in TBL disease with respect to iron status 
      biomarkers. Hence, we have studied the effect of Ss coinfection on the 
      circulating levels of iron status (ferritin, transferrin [TF], apotransferrin 
      [ApoT], hepcidin, hemopexin) biomarkers in TBL disease. Our results show that 
      TBL+Ss+ and/or TBL+Ss- individuals are associated with significantly altered 
      biochemical and hematological (red blood cell (RBC) counts, hemoglobin (Hb), 
      hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin 
      (MCH) were decreased, and platelets were increased) parameters compared to 
      TBL-Ss+ individuals. Our results also show that TBL+Ss+ coinfection is associated 
      with diminished circulating levels of ferritin, ApoT, hepcidin, and hemopexin 
      compared to TBL+Ss- individuals. TBL+Ss+ and TBL+Ss- groups are associated with 
      altered iron status biomarkers (decreased ferritin [TBL+Ss+ alone] and increased 
      TF, ApoT, hepcidin and hemopexin [TBL+Ss- alone]) compared to TBL-Ss+ group. The 
      heat map expression profile and principal component analysis (PCA) analysis of 
      iron status biomarkers were significantly altered in TBL+Ss+ compared to TBL+Ss- 
      and/or TBL-Ss+ individuals. A significant correlation (positive/negative) was 
      obtained among the biochemical and hematological parameters (white blood cells 
      (WBC)/ferritin, TF, and hepcidin, mean corpuscular hemoglobin concentration 
      (MCHC)/ferritin and hemopexin) with iron status biomarkers. Finally, receiver 
      operating characteristic (ROC) analysis revealed that hemopexin was significantly 
      associated with greater specificity and sensitivity in discriminating TBL+Ss+ and 
      TBL+Ss- coinfected individuals. Thus, our data conclude that Ss coinfection is 
      associated with altered iron status biomarkers indicating that coinfection might 
      alter the host-Mtb interface and could influence the disease pathogenesis.
CI  - Copyright (c) 2022 Kathamuthu, Rajamanickam, Sridhar, Baskaran and Babu.
FAU - Kathamuthu, Gokul Raj
AU  - Kathamuthu GR
AD  - National Institutes of Health-NIRT-International Center for Excellence in 
      Research, Chennai, India.
AD  - Indian Council of Medical Research-National Institute for Research in 
      Tuberculosis (ICMR-NIRT), Chennai, India.
FAU - Rajamanickam, Anuradha
AU  - Rajamanickam A
AD  - National Institutes of Health-NIRT-International Center for Excellence in 
      Research, Chennai, India.
FAU - Sridhar, Rathinam
AU  - Sridhar R
AD  - Government Stanley Medical Hospital, Chennai, India.
FAU - Baskaran, Dhanaraj
AU  - Baskaran D
AD  - Indian Council of Medical Research-National Institute for Research in 
      Tuberculosis (ICMR-NIRT), Chennai, India.
FAU - Babu, Subash
AU  - Babu S
AD  - National Institutes of Health-NIRT-International Center for Excellence in 
      Research, Chennai, India.
AD  - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious 
      Diseases, National Institutes of Health, Bethesda, MD, United States.
LA  - eng
PT  - Journal Article
DEP - 20221020
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - E1UOL152H7 (Iron)
RN  - 0 (Hepcidins)
RN  - 9013-71-2 (Hemopexin)
RN  - 9007-73-2 (Ferritins)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - *Strongyloidiasis/complications/diagnosis
MH  - Iron/metabolism
MH  - Hepcidins/metabolism
MH  - *Coinfection
MH  - Hemopexin/metabolism
MH  - *Tuberculosis, Lymph Node
MH  - Ferritins
MH  - Biomarkers
PMC - PMC9632344
OTO - NOTNLM
OT  - Strongyloides stercolaris
OT  - elisa
OT  - hematology
OT  - iron status biomarkers
OT  - tbl
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/08 06:00
MHDA- 2022/11/09 06:00
PMCR- 2022/01/01
CRDT- 2022/11/07 05:18
PHST- 2022/07/21 00:00 [received]
PHST- 2022/10/07 00:00 [accepted]
PHST- 2022/11/07 05:18 [entrez]
PHST- 2022/11/08 06:00 [pubmed]
PHST- 2022/11/09 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2022.999614 [doi]
PST - epublish
SO  - Front Immunol. 2022 Oct 20;13:999614. doi: 10.3389/fimmu.2022.999614. eCollection 
      2022.