PMID- 36341786
OWN - NLM
STAT- MEDLINE
DCOM- 20221114
LR  - 20221228
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 170
DP  - 2022 Dec
TI  - Inflammaging and body composition: New insights in diabetic and hypertensive 
      elderly men.
PG  - 112005
LID - S0531-5565(22)00314-X [pii]
LID - 10.1016/j.exger.2022.112005 [doi]
AB  - Age-related changes in the body's physiological responses play a critical role in 
      systemic arterial hypertension (SAH) and type 2 Diabetes mellitus (T2DM). SAH and 
      T2DM have clinically silent low-grade inflammation as a common risk factor. This 
      inflammation has a relevant element, the excess of fatty tissue. In this 
      scenario, little is known about how inflammatory markers interact with each 
      other. Therefore, this work evaluated the interplay among anthropometric, 
      biochemical, and inflammatory markers in the elderly with SAH and T2DM. Men aged 
      60-80 years old with SAH and T2DM were classified by body mass index (BMI) as 
      eutrophic elderly (EE, 24 individuals) or overweight elderly (OE, 25 
      individuals). Body composition analysis was performed using bioimpedance. Blood 
      samples were collected to perform inflammatory and biochemical evaluations. The 
      cytokines IL-17A, IL-1beta, IFN-y, TNF-alpha, and IL-10, were evaluated by ELISA. 
      Triglycerides, total and fractions of cholesterol, and glucose were measured by 
      spectrophotometry. Overweight elderly men had a higher glycemic index and an 
      increase in most anthropometric markers, as well as higher means for all 
      pro-inflammatory cytokines analyzed (IL-17A, IL-1beta, IFN-y, and TNF-alpha) in 
      comparison to their eutrophic elderly counterparts. However, there was a decrease 
      in IL-10 anti-inflammatory cytokine and IL-10/IL-17A ratio compared to their 
      eutrophic elderly counterparts. Although overweight elderly men have worsening 
      inflammatory parameters, the magnitude of their correlations with anthropometric 
      and biochemical parameters becomes less evident. The Bayesian networks highlight 
      that in the eutrophic elderly, IL-17A and TNF-alpha are the cytokines most associated 
      with interactions, and most of these interactions occur with biochemical 
      parameters. It is worth highlighting the role of IFN-y in overweight elderly men. 
      This cytokine influences IL-10 and TNF-alpha production, contributing to the 
      inflammatory profile exacerbated in this group.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Goncalves, Caroline Vieira
AU  - Goncalves CV
AD  - Multidisciplinary Institute of Health, Anisio Teixeira Campus, Federal University 
      of Bahia, 58 Rio de Contas Street, 17 Block, 58 Lot, Candeias, 45.029-094 Vitoria 
      da Conquista, Bahia, Brazil.
FAU - Ribeiro, Israel Souza
AU  - Ribeiro IS
AD  - Training Center in Health Sciences, Federal University of Southern Bahia, 58 
      Joana Angelica Square, Sao Jose, 45.988-058 Teixeira de Freitas, Bahia, Brazil.
FAU - Galantini, Maria Poliana Leite
AU  - Galantini MPL
AD  - Multidisciplinary Institute of Health, Anisio Teixeira Campus, Federal University 
      of Bahia, 58 Rio de Contas Street, 17 Block, 58 Lot, Candeias, 45.029-094 Vitoria 
      da Conquista, Bahia, Brazil.
FAU - Muniz, Igor Pereira Ribeiro
AU  - Muniz IPR
AD  - Multidisciplinary Institute of Health, Anisio Teixeira Campus, Federal University 
      of Bahia, 58 Rio de Contas Street, 17 Block, 58 Lot, Candeias, 45.029-094 Vitoria 
      da Conquista, Bahia, Brazil.
FAU - Lima, Paulo Henrique Bispo
AU  - Lima PHB
AD  - Multidisciplinary Institute of Health, Anisio Teixeira Campus, Federal University 
      of Bahia, 58 Rio de Contas Street, 17 Block, 58 Lot, Candeias, 45.029-094 Vitoria 
      da Conquista, Bahia, Brazil.
FAU - Santos, Gilvaneia Silva
AU  - Santos GS
AD  - Multidisciplinary Institute of Health, Anisio Teixeira Campus, Federal University 
      of Bahia, 58 Rio de Contas Street, 17 Block, 58 Lot, Candeias, 45.029-094 Vitoria 
      da Conquista, Bahia, Brazil.
FAU - da Silva, Robson Amaro Augusto
AU  - da Silva RAA
AD  - Multidisciplinary Institute of Health, Anisio Teixeira Campus, Federal University 
      of Bahia, 58 Rio de Contas Street, 17 Block, 58 Lot, Candeias, 45.029-094 Vitoria 
      da Conquista, Bahia, Brazil. Electronic address: robson.amaro@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221028
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 130068-27-8 (Interleukin-10)
RN  - 0 (Interleukin-17)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Humans
MH  - Male
MH  - Bayes Theorem
MH  - Biomarkers
MH  - *Body Composition
MH  - Cytokines
MH  - *Diabetes Mellitus, Type 2
MH  - *Hypertension
MH  - *Inflammation
MH  - Interleukin-10
MH  - Interleukin-17
MH  - Overweight/complications
MH  - Tumor Necrosis Factor-alpha
MH  - Middle Aged
OTO - NOTNLM
OT  - Body composition
OT  - Elderly men
OT  - Inflammation
OT  - Systemic arterial hypertension
OT  - Type 2 diabetes mellitus
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/11/08 06:00
MHDA- 2022/11/10 06:00
CRDT- 2022/11/07 06:15
PHST- 2022/08/09 00:00 [received]
PHST- 2022/10/24 00:00 [revised]
PHST- 2022/10/25 00:00 [accepted]
PHST- 2022/11/08 06:00 [pubmed]
PHST- 2022/11/10 06:00 [medline]
PHST- 2022/11/07 06:15 [entrez]
AID - S0531-5565(22)00314-X [pii]
AID - 10.1016/j.exger.2022.112005 [doi]
PST - ppublish
SO  - Exp Gerontol. 2022 Dec;170:112005. doi: 10.1016/j.exger.2022.112005. Epub 2022 
      Oct 28.