PMID- 36341840
OWN - NLM
STAT- MEDLINE
DCOM- 20221206
LR  - 20230105
IS  - 1096-0937 (Electronic)
IS  - 1087-1845 (Linking)
VI  - 163
DP  - 2022 Nov
TI  - Gene drive by Fusarium SKC1 is dependent on its competing allele.
PG  - 103749
LID - S1087-1845(22)00094-9 [pii]
LID - 10.1016/j.fgb.2022.103749 [doi]
AB  - The Fusarium verticillioides SKC1 gene driver is transmitted to offspring in a 
      biased manner through spore killing. The mechanism that allows SKC1 to kill 
      non-SKC1 offspring while sparing others is poorly understood. Here we report that 
      gene drive by SKC1 is dependent on SKC1's competing allele. We propose that 
      SKC1's competing allele influences the ability of a genome defense process to 
      detect SKC1, and we provide evidence that this genome defense process is meiotic 
      silencing by unpaired DNA (MSUD). Our findings suggest that the successful 
      deployment of gene drivers to control pathogenic fungi will require researchers 
      to consider how competing alleles influence the ability of gene drivers to be 
      detected by genome defense processes.
CI  - Published by Elsevier Inc.
FAU - Lohmar, Jessica M
AU  - Lohmar JM
AD  - USDA, Agricultural Research Service, National Center for Agricultural Utilization 
      Research, Mycotoxin Prevention and Applied Microbiology Unit, 1815 N. University 
      St., Peoria, IL 61604, USA.
FAU - Rhoades, Nicholas A
AU  - Rhoades NA
AD  - School of Biological Sciences, Illinois State University, Normal, IL 61790, USA.
FAU - Hammond, Thomas M
AU  - Hammond TM
AD  - School of Biological Sciences, Illinois State University, Normal, IL 61790, USA. 
      Electronic address: tmhammo@ilstu.edu.
FAU - Brown, Daren W
AU  - Brown DW
AD  - USDA, Agricultural Research Service, National Center for Agricultural Utilization 
      Research, Mycotoxin Prevention and Applied Microbiology Unit, 1815 N. University 
      St., Peoria, IL 61604, USA. Electronic address: daren.brown@usda.gov.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20221029
PL  - United States
TA  - Fungal Genet Biol
JT  - Fungal genetics and biology : FG & B
JID - 9607601
SB  - IM
MH  - *Fusarium/genetics
MH  - Alleles
MH  - *Gene Drive Technology
MH  - Meiosis
OTO - NOTNLM
OT  - Fusarium
OT  - Gene drive
OT  - MSUD
OT  - SKC1
OT  - Spore killer
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/11/08 06:00
MHDA- 2022/12/07 06:00
CRDT- 2022/11/07 06:20
PHST- 2022/08/05 00:00 [received]
PHST- 2022/10/22 00:00 [revised]
PHST- 2022/10/25 00:00 [accepted]
PHST- 2022/11/08 06:00 [pubmed]
PHST- 2022/12/07 06:00 [medline]
PHST- 2022/11/07 06:20 [entrez]
AID - S1087-1845(22)00094-9 [pii]
AID - 10.1016/j.fgb.2022.103749 [doi]
PST - ppublish
SO  - Fungal Genet Biol. 2022 Nov;163:103749. doi: 10.1016/j.fgb.2022.103749. Epub 2022 
      Oct 29.