PMID- 36343899
OWN - NLM
STAT- MEDLINE
DCOM- 20221125
LR  - 20221226
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 245
DP  - 2022 Dec
TI  - De novo molecular subtyping of salivary gland tissue in the context of Sjogren's 
      syndrome heterogeneity.
PG  - 109171
LID - S1521-6616(22)00252-2 [pii]
LID - 10.1016/j.clim.2022.109171 [doi]
AB  - Understanding the mechanistic features and molecular taxonomy of diseases holds 
      promise for the development of more effective treatments, especially for complex 
      heterogeneous diseases. Here, we analyzed transcriptomic datasets of salivary 
      gland tissues from patients with Sjogren's syndrome (SjS) to identify shared and 
      divergent cellular and molecular signatures. Three molecular subtypes of SjS 
      salivary gland tissue were identified: oxidative phosphorylation 
      (OxPhos)-dominant (C1), weak inflammatory with type I interferon signatures (C2), 
      and B cell receptor (BCR) signaling pathway-dominant (C3). C3 had the highest 
      focus score. Type I helper T cells and B cells were the dominant cell types in C1 
      and C3 tissues, respectively. Metformin and drugs targeting PI3K, BTK, and JAKs 
      were predicted to be effective treatments for C1 and C3 subtypes, respectively. 
      Three subtypes of SjS salivary gland with distinct molecular signatures were 
      identified. The results could contribute to optimal stratification of patients 
      for more effective treatment approaches.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Jung, Seung Min
AU  - Jung SM
AD  - Division of Rheumatology, Department of Internal Medicine, St. Vincent's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic 
      of Korea.
FAU - Baek, In-Woon
AU  - Baek IW
AD  - Division of Rheumatology, Department of Internal Medicine, Ewha Womans University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Park, Kyung-Su
AU  - Park KS
AD  - Division of Rheumatology, Department of Internal Medicine, St. Vincent's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic 
      of Korea.
FAU - Kim, Ki-Jo
AU  - Kim KJ
AD  - Division of Rheumatology, Department of Internal Medicine, St. Vincent's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic 
      of Korea. Electronic address: md21c@catholic.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20221105
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Interferon Type I)
SB  - IM
MH  - Humans
MH  - *Sjogren's Syndrome/genetics/metabolism
MH  - Salivary Glands/metabolism
MH  - B-Lymphocytes/metabolism
MH  - *Interferon Type I/metabolism
MH  - Transcriptome
OTO - NOTNLM
OT  - Key driver gene
OT  - Molecular signature
OT  - Salivary gland
OT  - Sjogren's syndrome
OT  - Therapeutic target
COIS- Declaration of Competing Interest The authors declare no competing interests.
EDAT- 2022/11/08 06:00
MHDA- 2022/11/26 06:00
CRDT- 2022/11/07 19:27
PHST- 2022/08/24 00:00 [received]
PHST- 2022/10/26 00:00 [revised]
PHST- 2022/10/27 00:00 [accepted]
PHST- 2022/11/08 06:00 [pubmed]
PHST- 2022/11/26 06:00 [medline]
PHST- 2022/11/07 19:27 [entrez]
AID - S1521-6616(22)00252-2 [pii]
AID - 10.1016/j.clim.2022.109171 [doi]
PST - ppublish
SO  - Clin Immunol. 2022 Dec;245:109171. doi: 10.1016/j.clim.2022.109171. Epub 2022 Nov 
      5.