PMID- 36344703
OWN - NLM
STAT- MEDLINE
DCOM- 20230224
LR  - 20230224
IS  - 1860-1499 (Electronic)
IS  - 1860-1499 (Linking)
VI  - 56
IP  - 1
DP  - 2023 Mar
TI  - Usefulness of SynCAM3 and cyclin D1 immunohistochemistry in distinguishing 
      superficial CD34-positive fibroblastic tumor from its histological mimics.
PG  - 69-77
LID - 10.1007/s00795-022-00341-w [doi]
AB  - Superficial CD34-positive fibroblastic tumor (SCPFT) is a 
      fibroblastic/myofibroblastic soft tissue tumor of rarely metastasizing 
      intermediate malignancy. Some recent studies have described a relationship 
      between SCPFT and PRDM10-rearranged soft tissue tumor (PRT) based on SynCAM3 and 
      PRDM10 expression on immunohistochemistry. We performed CD34, cytokeratin 
      AE1/AE3, SynCAM3, and PRDM10 immunohistochemistry in SCPFT and its histological 
      mimics, including myxoinflammatory fibroblastic sarcoma (MIFS), superficially 
      localized myxofibrosarcoma (MFS), and undifferentiated pleomorphic sarcoma. We 
      also examined cyclin D1 expression because it is expressed in MIFS and MFS. We 
      conducted fluorescence in situ hybridization (FISH) of PRDM10 rearrangement in 
      SCPFT cases. On immunohistochemistry, only SCPFT showed strong and diffuse 
      SynCAM3 expression. SCPFT also exhibited strong nuclear and weak cytoplasmic 
      cyclin D1 expression, which was similar to that observed in MIFS. Two of five 
      SCPFT cases exhibited nuclear PRDM10 expression. FISH revealed PRDM10 split 
      signals in 44% and 24% of tumor cells in two SCPFT cases showing nuclear PRDM10 
      expression on immunohistochemistry, respectively. A minority of non-SCPFT cases 
      showed focal SynCAM3 expression, but a combination of SynCAM3 and cyclin D1 in 
      addition to CD34 and cytokeratin AE1/AE3 may be useful for the differential 
      diagnosis of SCPFT and its histological mimics.
CI  - (c) 2022. The Author(s) under exclusive licence to The Japanese Society for 
      Clinical Molecular Morphology.
FAU - Sugita, Shintaro
AU  - Sugita S
AD  - Department of Surgical Pathology, School of Medicine, Sapporo Medical University, 
      Sapporo, Hokkaido, 060-8543, Japan.
FAU - Takenami, Tomoko
AU  - Takenami T
AD  - Department of Surgical Pathology, School of Medicine, Sapporo Medical University, 
      Sapporo, Hokkaido, 060-8543, Japan.
FAU - Kido, Tomomi
AU  - Kido T
AD  - Department of Surgical Pathology, School of Medicine, Sapporo Medical University, 
      Sapporo, Hokkaido, 060-8543, Japan.
FAU - Aoyama, Tomoyuki
AU  - Aoyama T
AD  - Department of Surgical Pathology, School of Medicine, Sapporo Medical University, 
      Sapporo, Hokkaido, 060-8543, Japan.
FAU - Hosaka, Michiko
AU  - Hosaka M
AD  - Department of Surgical Pathology, School of Medicine, Sapporo Medical University, 
      Sapporo, Hokkaido, 060-8543, Japan.
FAU - Segawa, Keiko
AU  - Segawa K
AD  - Department of Surgical Pathology, School of Medicine, Sapporo Medical University, 
      Sapporo, Hokkaido, 060-8543, Japan.
FAU - Sugawara, Taro
AU  - Sugawara T
AD  - Department of Surgical Pathology, School of Medicine, Sapporo Medical University, 
      Sapporo, Hokkaido, 060-8543, Japan.
FAU - Fujita, Hiromi
AU  - Fujita H
AD  - Department of Surgical Pathology, School of Medicine, Sapporo Medical University, 
      Sapporo, Hokkaido, 060-8543, Japan.
FAU - Murahashi, Yasutaka
AU  - Murahashi Y
AD  - Department of Orthopedic Surgery, School of Medicine, Sapporo Medical University, 
      Sapporo, Hokkaido, 060-8543, Japan.
FAU - Emori, Makoto
AU  - Emori M
AD  - Department of Orthopedic Surgery, School of Medicine, Sapporo Medical University, 
      Sapporo, Hokkaido, 060-8543, Japan.
FAU - Tsuyuki, Atsushi
AU  - Tsuyuki A
AD  - Department of Pathology, Japanese Red Cross Aichi Medical Center Nagoya Daini 
      Hospital, Nagoya, Aichi, 466-8650, Japan.
FAU - Hasegawa, Tadashi
AU  - Hasegawa T
AD  - Department of Surgical Pathology, School of Medicine, Sapporo Medical University, 
      Sapporo, Hokkaido, 060-8543, Japan. hasetada@sapmed.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20221108
PL  - Japan
TA  - Med Mol Morphol
JT  - Medical molecular morphology
JID - 101239023
RN  - 136601-57-5 (Cyclin D1)
RN  - 68238-35-7 (Keratins)
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Humans
MH  - Immunohistochemistry
MH  - Cyclin D1
MH  - In Situ Hybridization, Fluorescence
MH  - *Soft Tissue Neoplasms/diagnosis/pathology
MH  - *Fibrosarcoma/pathology
MH  - *Skin Neoplasms
MH  - Keratins
MH  - Biomarkers, Tumor
OTO - NOTNLM
OT  - Cyclin D1
OT  - Fluorescence in situ hybridization
OT  - Immunohistochemistry
OT  - Myxofibrosarcoma
OT  - Myxoinflammatory fibroblastic sarcoma
OT  - PRDM10
OT  - Superficial CD34-positive fibroblastic tumor
OT  - SynCAM3
OT  - Undifferentiated pleomorphic sarcoma
EDAT- 2022/11/08 06:00
MHDA- 2023/02/25 06:00
CRDT- 2022/11/07 23:38
PHST- 2022/10/12 00:00 [received]
PHST- 2022/10/31 00:00 [accepted]
PHST- 2022/11/08 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2022/11/07 23:38 [entrez]
AID - 10.1007/s00795-022-00341-w [pii]
AID - 10.1007/s00795-022-00341-w [doi]
PST - ppublish
SO  - Med Mol Morphol. 2023 Mar;56(1):69-77. doi: 10.1007/s00795-022-00341-w. Epub 2022 
      Nov 8.