PMID- 36346717 OWN - NLM STAT- MEDLINE DCOM- 20221207 LR - 20230104 IS - 1520-5851 (Electronic) IS - 0013-936X (Print) IS - 0013-936X (Linking) VI - 56 IP - 23 DP - 2022 Dec 6 TI - Influence of Life-History Parameters on Persistent Organic Pollutant Concentrations in Blubber of Eastern North Pacific Gray Whales (Eschrichtius robustus). PG - 17119-17130 LID - 10.1021/acs.est.2c05998 [doi] AB - Exposure to persistent organic pollutants (POPs) can significantly impact marine mammal health, reproduction, and fitness. This study addresses a significant 20-year gap in gray whale contaminant monitoring through analysis of POPs in 120 blubber biopsies. The scope of this substantial sample set is noteworthy in its range and diversity with collection between 2003 and 2017 along North America's west coast and across diverse sex, age, and reproductive parameters, including paired mothers and calves. Mean blubber concentrations of polychlorinated biphenyls ( summation operatorPCBs), dichlorodiphenyltrichloroethanes ( summation operatorDDTs), and chlordanes ( summation operatorCHLs) generally decreased since previous reports (1968-1999). This is the first report of polybrominated diphenyl ethers (PBDEs) and select hexachlorocyclohexanes (HCHs) in this species. Statistical modeling of the 19 most frequently detected compounds in this dataset revealed sex-, age-, and reproductive status-related patterns, predominantly attributed to maternal offloading. Mean POP concentrations differed significantly by sex in adults (17 compounds, up to 3-fold higher in males) but not in immatures (all 19 compounds). Mean POP concentrations were significantly greater in adults versus immatures in both males (17 compounds, up to 12-fold) and females (13 compounds, up to 3-fold). POP concentrations were detected with compound-specific patterns in nursing calves, confirming maternal offloading for the first time in this species. FAU - Hayes, Kia R R AU - Hayes KRR AUID- ORCID: 0000-0002-2661-7362 AD - The Institute of Environmental and Human Health, Texas Tech University, Lubbock, Texas 79409, United States. AD - Environmental and Fisheries Sciences Division, Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Seattle, Washington 98112, United States. AD - Ocean Associates, Inc., Arlington, Virginia 22207, United States. FAU - Ylitalo, Gina M AU - Ylitalo GM AD - Environmental and Fisheries Sciences Division, Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Seattle, Washington 98112, United States. FAU - Anderson, Todd A AU - Anderson TA AUID- ORCID: 0000-0001-8176-6339 AD - The Institute of Environmental and Human Health, Texas Tech University, Lubbock, Texas 79409, United States. FAU - Urban R, Jorge AU - Urban R J AD - Departamento de Ciencias Marinas y Costeras, Universidad Autonoma de Baja California Sur, La Paz, BCS 23085, Mexico. FAU - Jacobsen, Jeff K AU - Jacobsen JK AUID- ORCID: 0000-0002-5972-3292 AD - VE Enterprises, McKinleyville, California 95519, United States. FAU - Scordino, Jonathan J AU - Scordino JJ AD - Marine Mammal Program, Makah Fisheries Management, Makah Tribe, Neah Bay, Washington 98357, United States. FAU - Lang, Aimee R AU - Lang AR AD - Ocean Associates, Inc., Arlington, Virginia 22207, United States. AD - Southwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, La Jolla, California 92037, United States. FAU - Baugh, Keri A AU - Baugh KA AD - Environmental and Fisheries Sciences Division, Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Seattle, Washington 98112, United States. FAU - Bolton, Jennie L AU - Bolton JL AD - Environmental and Fisheries Sciences Division, Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Seattle, Washington 98112, United States. FAU - Bruniche-Olsen, Anna AU - Bruniche-Olsen A AD - Department of Forestry and Natural Resources, Purdue University, West Lafayette, Indiana 47907, United States. FAU - Calambokidis, John AU - Calambokidis J AD - Cascadia Research Collective, Olympia, Washington 98501, United States. FAU - Martinez-Aguilar, Sergio AU - Martinez-Aguilar S AD - Departamento de Ciencias Marinas y Costeras, Universidad Autonoma de Baja California Sur, La Paz, BCS 23085, Mexico. FAU - Subbiah, Seenivasan AU - Subbiah S AD - The Institute of Environmental and Human Health, Texas Tech University, Lubbock, Texas 79409, United States. FAU - Gribble, Matthew O AU - Gribble MO AD - Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States. FAU - Godard-Codding, Celine A J AU - Godard-Codding CAJ AUID- ORCID: 0000-0001-9386-6767 AD - The Institute of Environmental and Human Health, Texas Tech University, Lubbock, Texas 79409, United States. LA - eng GR - U54 AG062334/AG/NIA NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20221108 PL - United States TA - Environ Sci Technol JT - Environmental science & technology JID - 0213155 RN - 0 (Persistent Organic Pollutants) RN - 0 (Water Pollutants, Chemical) RN - DFC2HB4I0K (Polychlorinated Biphenyls) RN - 0 (Halogenated Diphenyl Ethers) SB - IM MH - Animals MH - Male MH - Female MH - Persistent Organic Pollutants MH - Environmental Monitoring MH - Whales MH - *Water Pollutants, Chemical/analysis MH - *Polychlorinated Biphenyls/analysis MH - Halogenated Diphenyl Ethers/analysis MH - Adipose Tissue/chemistry PMC - PMC9730851 OTO - NOTNLM OT - gray whale OT - life-history OT - marine mammals OT - organochlorines OT - pollutants COIS- The authors declare no competing financial interest. EDAT- 2022/11/09 06:00 MHDA- 2022/12/10 06:00 PMCR- 2022/12/08 CRDT- 2022/11/08 12:42 PHST- 2022/11/09 06:00 [pubmed] PHST- 2022/12/10 06:00 [medline] PHST- 2022/11/08 12:42 [entrez] PHST- 2022/12/08 00:00 [pmc-release] AID - 10.1021/acs.est.2c05998 [doi] PST - ppublish SO - Environ Sci Technol. 2022 Dec 6;56(23):17119-17130. doi: 10.1021/acs.est.2c05998. Epub 2022 Nov 8.