PMID- 36348056 OWN - NLM STAT- MEDLINE DCOM- 20230404 LR - 20230404 IS - 1433-9285 (Electronic) IS - 0933-7954 (Linking) VI - 58 IP - 4 DP - 2023 Apr TI - Migrant status, clinical symptoms and functional outcome in youth at clinical high risk for psychosis: findings from the NAPLS-3 study. PG - 559-568 LID - 10.1007/s00127-022-02383-y [doi] AB - PURPOSE: Migrant status is a known risk factor for psychosis, but the underlying causes of this vulnerability are poorly understood. Recently, studies have begun to explore whether migrant status predicts transition to psychosis in individuals at clinical high risk (CHR) for psychosis. Results, however, have been inconclusive. The present study assessed the impact of migrant status on clinical symptoms and functional outcome in individuals at CHR for psychosis who took part in the NAPLS-3 study. METHODS: Participants' migrant status was classified as native-born, first-generation, or second-generation migrant. Clinical symptoms were assessed using the Structured Interview for Psychosis-Risk Syndromes (SIPS); functional outcome was measured using the Global Functioning Scales:Social and Role (GF:S; GF:R). Assessments were conducted at baseline, 12-months, 18-months, and 24-months follow-up. Generalized linear mixed models for repeated measures were used to examine changes over time and differences between groups. RESULTS: The overall sample included 710 individuals at CHR for psychosis (54.2% males; Age: M = 18.19; SD = 4.04). A mixed model analysis was conducted, and no significant differences between groups in symptoms or functioning were observed at any time point. Over time, significant improvement in symptoms and functioning was observed within each group. Transition rates did not differ across groups. CONCLUSION: We discuss potential factors that might explain the lack of group differences. Overall, migrants are a heterogeneous population. Discerning the impact of migration from that of neighborhood ethnic density, social disadvantage or socio-economic status of different ethnic groups could help better understand vulnerability and resilience to psychosis. CI - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany. FAU - Barbato, Mariapaola AU - Barbato M AUID- ORCID: 0000-0003-3184-0603 AD - Department of Psychology, College of Natural and Health Sciences, Zayed University, Dubai, UAE. FAU - Liu, Lu AU - Liu L AD - Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. FAU - Bearden, Carrie E AU - Bearden CE AD - Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA. FAU - Cadenhead, Kristin S AU - Cadenhead KS AD - Department of Psychiatry, UCSD, San Diego, CA, USA. FAU - Cornblatt, Barbara A AU - Cornblatt BA AD - Department of Psychiatry, Zucker Hillside Hospital, Long Island, NY, USA. FAU - Keshavan, Matcheri AU - Keshavan M AD - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Boston, MA, USA. FAU - Mathalon, Daniel H AU - Mathalon DH AD - Department of Psychiatry, UCSF, and SFVA Medical Center, San Francisco, CA, USA. FAU - McGlashan, Thomas H AU - McGlashan TH AD - Department of Psychiatry, Yale University, New Haven, CT, USA. FAU - Perkins, Diana O AU - Perkins DO AD - Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA. FAU - Seidman, Larry J AU - Seidman LJ AD - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Boston, MA, USA. FAU - Stone, William AU - Stone W AD - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Boston, MA, USA. FAU - Tsuang, Ming T AU - Tsuang MT AD - Department of Psychiatry, UCSD, San Diego, CA, USA. AD - Institute of Genomic Medicine, University of California, La Jolla, CA, USA. FAU - Walker, Elaine F AU - Walker EF AD - Departments of Psychology and Psychiatry, Emory University, Atlanta, GA, USA. FAU - Woods, Scott W AU - Woods SW AD - Department of Psychiatry, Yale University, New Haven, CT, USA. FAU - Cannon, Tyrone D AU - Cannon TD AD - Department of Psychiatry, Yale University, New Haven, CT, USA. AD - Department of Psychology, Yale University, New Haven, CT, USA. FAU - Addington, Jean AU - Addington J AD - Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. jmadding@ucalgary.ca. AD - Mathison Centre for Mental Health Research & Education, University of Calgary, 3280 Hospital Drive NW, Calgary, AB, T2N 4Z6, Canada. jmadding@ucalgary.ca. LA - eng GR - U01MH081984/MH/NIMH NIH HHS/United States GR - U01MH081928/MH/NIMH NIH HHS/United States GR - U01MH081944/MH/NIMH NIH HHS/United States GR - U01MH081902/MH/NIMH NIH HHS/United States GR - U01MH082004/MH/NIMH NIH HHS/United States GR - U01MH081988/MH/NIMH NIH HHS/United States GR - U01MH082022/MH/NIMH NIH HHS/United States GR - U01MH076989/MH/NIMH NIH HHS/United States GR - UO1MH081857/MH/NIMH NIH HHS/United States GR - U01MH081984/MH/NIMH NIH HHS/United States GR - U01MH081928/MH/NIMH NIH HHS/United States GR - U01MH081944/MH/NIMH NIH HHS/United States GR - U01MH081902/MH/NIMH NIH HHS/United States GR - U01MH081902/MH/NIMH NIH HHS/United States GR - U01MH082004/MH/NIMH NIH HHS/United States GR - U01MH081988/MH/NIMH NIH HHS/United States GR - U01MH082022/MH/NIMH NIH HHS/United States GR - U01MH076989/MH/NIMH NIH HHS/United States GR - UO1MH081857/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20221108 PL - Germany TA - Soc Psychiatry Psychiatr Epidemiol JT - Social psychiatry and psychiatric epidemiology JID - 8804358 SB - IM MH - Male MH - Humans MH - Adolescent MH - Female MH - *Transients and Migrants MH - Longitudinal Studies MH - *Psychotic Disorders/diagnosis/epidemiology MH - Risk Factors MH - Prodromal Symptoms OTO - NOTNLM OT - Clinical high risk OT - Functional outcome OT - Immigration OT - Psychosis EDAT- 2022/11/09 06:00 MHDA- 2023/04/04 06:42 CRDT- 2022/11/08 23:35 PHST- 2021/11/25 00:00 [received] PHST- 2022/10/28 00:00 [accepted] PHST- 2023/04/04 06:42 [medline] PHST- 2022/11/09 06:00 [pubmed] PHST- 2022/11/08 23:35 [entrez] AID - 10.1007/s00127-022-02383-y [pii] AID - 10.1007/s00127-022-02383-y [doi] PST - ppublish SO - Soc Psychiatry Psychiatr Epidemiol. 2023 Apr;58(4):559-568. doi: 10.1007/s00127-022-02383-y. Epub 2022 Nov 8.