PMID- 36348079
OWN - NLM
STAT- MEDLINE
DCOM- 20221201
LR  - 20231202
IS  - 2042-0226 (Electronic)
IS  - 1672-7681 (Print)
IS  - 1672-7681 (Linking)
VI  - 19
IP  - 12
DP  - 2022 Dec
TI  - Defining newly formed and tissue-resident bone marrow-derived macrophages in 
      adult mice based on lysozyme expression.
PG  - 1333-1346
LID - 10.1038/s41423-022-00936-4 [doi]
AB  - Tissue-resident macrophages are derived from different precursor cells and 
      display different phenotypes. Reconstitution of the tissue-resident macrophages 
      of inflamed or damaged tissues in adults can be achieved by bone marrow-derived 
      monocytes/macrophages. Using lysozyme (Lysm)-GFP-reporter mice, we found that 
      alveolar macrophages (AMs), Kupffer cells, red pulp macrophages (RpMacs), and 
      kidney-resident macrophages were Lysm-GFP(-), whereas all monocytes in the fetal 
      liver, adult bone marrow, and blood were Lysm-GFP(+). Donor-derived Lysm-GFP(+) 
      resident macrophages gradually became Lysm-GFP(-) in recipients and developed 
      gene expression profiles characteristic of tissue-resident macrophages. Thus, 
      Lysm may be used to distinguish newly formed and long-term surviving 
      tissue-resident macrophages that were derived from bone marrow precursor cells in 
      adult mice under pathological conditions. Furthermore, we found that Irf4 might 
      be essential for resident macrophage differentiation in all tissues, while 
      cytokine and receptor pathways, mTOR signaling pathways, and fatty acid metabolic 
      processes predominantly regulated the differentiation of RpMacs, Kupffer cells, 
      and kidney macrophages, respectively. Deficiencies in ST2, mechanistic target of 
      rapamycin (mTOR) and fatty acid-binding protein 5 (FABP5) differentially impaired 
      the differentiation of tissue-resident macrophages from bone marrow-derived 
      monocytes/macrophages in the lungs, liver, and kidneys. These results indicate 
      that a combination of shared and unique signaling pathways coordinately shape 
      tissue-resident macrophage differentiation in various tissues.
CI  - (c) 2022. The Author(s), under exclusive licence to CSI and USTC.
FAU - Lei, Tong
AU  - Lei T
AD  - State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy 
      of Sciences, Beijing, China.
AD  - College of Life Science, University of Chinese Academy of Sciences, Beijing, 
      China.
FAU - Zhang, Jiayu
AU  - Zhang J
AD  - State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy 
      of Sciences, Beijing, China.
AD  - Cunji Medical School, University of Chinese Academy of Sciences, Beijing, China.
FAU - Zhang, Qian
AU  - Zhang Q
AD  - State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy 
      of Sciences, Beijing, China.
AD  - Cunji Medical School, University of Chinese Academy of Sciences, Beijing, China.
FAU - Ma, Xinran
AU  - Ma X
AD  - State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy 
      of Sciences, Beijing, China.
AD  - College of Life Science, University of Chinese Academy of Sciences, Beijing, 
      China.
FAU - Xu, Yanan
AU  - Xu Y
AD  - State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy 
      of Sciences, Beijing, China.
FAU - Zhao, Yang
AU  - Zhao Y
AD  - State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy 
      of Sciences, Beijing, China.
FAU - Zhang, Lianfeng
AU  - Zhang L
AD  - Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, 
      Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 
      Peking Union Medical College, Beijing, China. zhanglf@cnilas.org.
FAU - Lu, Zhongbing
AU  - Lu Z
AD  - College of Life Science, University of Chinese Academy of Sciences, Beijing, 
      China. luzhongbing@ucas.ac.cn.
FAU - Zhao, Yong
AU  - Zhao Y
AUID- ORCID: 0000-0003-2850-3008
AD  - State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy 
      of Sciences, Beijing, China. zhaoy@ioz.ac.cn.
AD  - Cunji Medical School, University of Chinese Academy of Sciences, Beijing, China. 
      zhaoy@ioz.ac.cn.
AD  - Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. 
      zhaoy@ioz.ac.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221108
PL  - China
TA  - Cell Mol Immunol
JT  - Cellular & molecular immunology
JID - 101242872
RN  - EC 3.2.1.17 (Muramidase)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Mice
MH  - Animals
MH  - *Muramidase/metabolism
MH  - *Macrophages/metabolism
MH  - Monocytes
MH  - Kupffer Cells
MH  - TOR Serine-Threonine Kinases/metabolism
PMC - PMC9708686
OTO - NOTNLM
OT  - Cytokine
OT  - Inflammation
OT  - Kupffer cells
OT  - Lysozyme
OT  - Metabolism
OT  - Tissue-resident macrophages
COIS- The authors declare no competing interests.
EDAT- 2022/11/09 06:00
MHDA- 2022/12/02 06:00
PMCR- 2023/12/01
CRDT- 2022/11/08 23:37
PHST- 2022/03/22 00:00 [received]
PHST- 2022/10/08 00:00 [accepted]
PHST- 2022/11/09 06:00 [pubmed]
PHST- 2022/12/02 06:00 [medline]
PHST- 2022/11/08 23:37 [entrez]
PHST- 2023/12/01 00:00 [pmc-release]
AID - 10.1038/s41423-022-00936-4 [pii]
AID - 936 [pii]
AID - 10.1038/s41423-022-00936-4 [doi]
PST - ppublish
SO  - Cell Mol Immunol. 2022 Dec;19(12):1333-1346. doi: 10.1038/s41423-022-00936-4. 
      Epub 2022 Nov 8.