PMID- 36348185
OWN - NLM
STAT- MEDLINE
DCOM- 20221220
LR  - 20230129
IS  - 1548-3576 (Electronic)
IS  - 1548-3568 (Print)
IS  - 1548-3568 (Linking)
VI  - 19
IP  - 6
DP  - 2022 Dec
TI  - Consolidated Overview of Notifiable Adverse Events in the U.S. President's 
      Emergency Plan for AIDS Relief's Voluntary Medical Male Circumcision Program 
      Through 2020.
PG  - 508-515
LID - 10.1007/s11904-022-00636-8 [doi]
AB  - PURPOSE OF REVIEW: Through December 2020, the U.S. President's Emergency Plan for 
      AIDS Relief (PEPFAR) supported more than 25 million voluntary medical male 
      circumcisions (VMMC) as part of the combined HIV prevention strategy in 15 
      African countries. PEPFAR monitors defined adverse events (AEs) occurring within 
      30 days of VMMC through its notifiable adverse event reporting system (NAERS). 
      All NAERS reports through December 2020 were reviewed to quantify AE type, 
      severity, and relation to the VMMC procedure. Interventions to improve client 
      safety based on NAERS findings are described. RECENT FINDINGS: Fourteen countries 
      reported 446 clients with notifiable adverse events (NAEs); 394/446 (88%) were 
      determined VMMC-related, representing approximately 18 NAE reports per million 
      circumcisions. Fatalities comprised 56/446 (13%) with 24/56 (43%) of fatalities 
      determined VMMC-related, representing 0.96 VMMC-related fatalities per million 
      circumcisions. The remaining 390 NAEs were non-fatal with 370/390 (95%) 
      VMMC-related. Multiple programmatic changes have been made based on NAERS data to 
      improve client safety. Client safety is paramount in this surgical program 
      designed for individual and population-level benefit. Surveillance of rare but 
      severe complications following circumcision has identified pre-existing or new 
      safety concerns and guided continuous programmatic improvement.
CI  - (c) 2022. This is a U.S. Government work and not under copyright protection in the 
      US; foreign copyright protection may apply.
FAU - Lucas, Todd
AU  - Lucas T
AUID- ORCID: 0000-0002-8785-1830
AD  - U.S. Centers for Disease Control and Prevention, Division of Global HIV and TB, 
      HIV Prevention Branch, Atlanta, GA, USA. tlucas@cdc.gov.
FAU - Cooney, Caroline
AU  - Cooney C
AD  - U.S. Department of State, Office of the U.S. Global AIDS Coordinator and Health 
      Diplomacy, Washington, DC, USA.
FAU - Prainito, Amber
AU  - Prainito A
AD  - U.S. Department of State, Office of the U.S. Global AIDS Coordinator and Health 
      Diplomacy, Washington, DC, USA.
FAU - Godfrey, Catherine
AU  - Godfrey C
AD  - U.S. Department of State, Office of the U.S. Global AIDS Coordinator and Health 
      Diplomacy, Washington, DC, USA.
FAU - Kiggundu, Valerian
AU  - Kiggundu V
AD  - U.S. Agency for International Development, Global Health, Office of HIV/AIDS, 
      Washington, DC, USA.
FAU - Thomas, Anne Goldzier
AU  - Thomas AG
AD  - U.S. Department of Defense HIV/AIDS Prevention Program, Defense Health Agency, 
      San Diego, CA, USA.
FAU - Ridzon, Renee
AU  - Ridzon R
AD  - U.S. Department of State, Office of the U.S. Global AIDS Coordinator and Health 
      Diplomacy, Washington, DC, USA.
FAU - Toledo, Carlos
AU  - Toledo C
AD  - U.S. Centers for Disease Control and Prevention, Division of Global HIV and TB, 
      HIV Prevention Branch, Atlanta, GA, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221108
PL  - United States
TA  - Curr HIV/AIDS Rep
JT  - Current HIV/AIDS reports
JID - 101235661
SB  - IM
MH  - Male
MH  - Humans
MH  - *Circumcision, Male/adverse effects
MH  - *Acquired Immunodeficiency Syndrome
MH  - *HIV Infections/epidemiology
MH  - Voluntary Programs
MH  - Africa
PMC - PMC9643893
OTO - NOTNLM
OT  - Adverse event
OT  - Complication
OT  - HIV prevention
OT  - Male circumcision
COIS- The authors declare no competing interests.
EDAT- 2022/11/09 06:00
MHDA- 2022/12/21 06:00
PMCR- 2022/11/08
CRDT- 2022/11/08 23:45
PHST- 2022/08/19 00:00 [accepted]
PHST- 2022/11/09 06:00 [pubmed]
PHST- 2022/12/21 06:00 [medline]
PHST- 2022/11/08 23:45 [entrez]
PHST- 2022/11/08 00:00 [pmc-release]
AID - 10.1007/s11904-022-00636-8 [pii]
AID - 636 [pii]
AID - 10.1007/s11904-022-00636-8 [doi]
PST - ppublish
SO  - Curr HIV/AIDS Rep. 2022 Dec;19(6):508-515. doi: 10.1007/s11904-022-00636-8. Epub 
      2022 Nov 8.