PMID- 36348344
OWN - NLM
STAT- MEDLINE
DCOM- 20221110
LR  - 20221116
IS  - 1471-2474 (Electronic)
IS  - 1471-2474 (Linking)
VI  - 23
IP  - 1
DP  - 2022 Nov 8
TI  - Autologous micro-fragmented adipose tissue associated with arthroscopy in 
      moderate-severe knee osteoarthritis: outcome at two year follow-up.
PG  - 963
LID - 10.1186/s12891-022-05921-6 [doi]
LID - 963
AB  - BACKGROUND: Adipose tissue has recently gained growing interest in the treatment 
      of osteoarthritis (OA). The aim of the present study was to evaluate the efficacy 
      of a single injection of autologous micro-fragmented adipose tissue (aMFAT) 
      associated with arthroscopy (cartilage debridement/meniscal regularization or 
      selective meniscectomy/micro-drilling) for symptomatic knee OA. METHODS: This 
      retrospective, single-center study included 49 patients (50 knees) affected by 
      knee OA (radiographic Kellgren-Lawrence III-IV) treated with a single injection 
      of autologous micro-fragmented adipose tissue and knee arthroscopy. Knee Injury 
      and Osteoarthritis Outcome Score (KOOS) and subjective International Knee 
      Documentation Committee (IKDC) score were the primary outcome measures and were 
      collected at one and 2 years post-operatively. Patients were divided into 
      clusters based on age, complexity of arthroscopic procedures and chondral lesion 
      grade. RESULTS: Four patients underwent knee replacement (8%). No major adverse 
      events were reported. Minimal Clinically Important Difference (MCID) for KOOS and 
      IKDC was reached by 84 and 74% of all cases at 1 year and by 80 and 76% at 2 
      years, respectively. High grade chondral lesions negatively affected the outcome 
      at 2 years follow-up (p < 0.05 for IKDC, KOOS overall and 3 out of 5 subscales). 
      CONCLUSION: The injection of micro-fragmented adipose tissue associated with 
      arthroscopy demonstrated to be a safe and effective procedure for the treatment 
      of knee OA, with a substantial improvement in IKDC and KOOS scores and without 
      major complications.
CI  - (c) 2022. The Author(s).
FAU - Giorgini, Andrea
AU  - Giorgini A
AD  - Department of Orthopaedic Surgery, Azienda Ospedaliero Universitaria di Modena, 
      University of Modena and Reggio-Emilia, Modena, Italy.
FAU - Selleri, Filippo
AU  - Selleri F
AUID- ORCID: 0000-0001-6404-5134
AD  - Department of Orthopaedic Surgery, Azienda Ospedaliero Universitaria di Modena, 
      University of Modena and Reggio-Emilia, Modena, Italy. filipposelleri@gmail.com.
FAU - Zambianchi, Francesco
AU  - Zambianchi F
AUID- ORCID: 0000-0002-7634-5692
AD  - Department of Orthopaedic Surgery, Azienda Ospedaliero Universitaria di Modena, 
      University of Modena and Reggio-Emilia, Modena, Italy.
FAU - Cataldo, Giacomo
AU  - Cataldo G
AD  - Department of Orthopaedic Surgery, Azienda Ospedaliero Universitaria di Modena, 
      University of Modena and Reggio-Emilia, Modena, Italy.
FAU - Francioni, Elena
AU  - Francioni E
AD  - Department of Orthopaedic Surgery, Azienda Ospedaliero Universitaria di Modena, 
      University of Modena and Reggio-Emilia, Modena, Italy.
FAU - Catani, Fabio
AU  - Catani F
AUID- ORCID: 0000-0002-1078-7666
AD  - Department of Orthopaedic Surgery, Azienda Ospedaliero Universitaria di Modena, 
      University of Modena and Reggio-Emilia, Modena, Italy.
LA  - eng
PT  - Journal Article
DEP - 20221108
PL  - England
TA  - BMC Musculoskelet Disord
JT  - BMC musculoskeletal disorders
JID - 100968565
SB  - IM
MH  - Humans
MH  - *Osteoarthritis, Knee/diagnostic imaging/surgery/pathology
MH  - Arthroscopy/adverse effects/methods
MH  - Retrospective Studies
MH  - Follow-Up Studies
MH  - Knee Joint/diagnostic imaging/surgery/pathology
MH  - Adipose Tissue/diagnostic imaging/surgery
MH  - Treatment Outcome
PMC - PMC9641752
OTO - NOTNLM
OT  - Arthroscopy
OT  - Cartilage
OT  - Intra-articular injection
OT  - Knee
OT  - Osteoarthritis
OT  - micro-fragmented adipose tissue
COIS- No
EDAT- 2022/11/09 06:00
MHDA- 2022/11/11 06:00
PMCR- 2022/11/08
CRDT- 2022/11/08 23:57
PHST- 2022/02/28 00:00 [received]
PHST- 2022/10/17 00:00 [accepted]
PHST- 2022/11/08 23:57 [entrez]
PHST- 2022/11/09 06:00 [pubmed]
PHST- 2022/11/11 06:00 [medline]
PHST- 2022/11/08 00:00 [pmc-release]
AID - 10.1186/s12891-022-05921-6 [pii]
AID - 5921 [pii]
AID - 10.1186/s12891-022-05921-6 [doi]
PST - epublish
SO  - BMC Musculoskelet Disord. 2022 Nov 8;23(1):963. doi: 10.1186/s12891-022-05921-6.