PMID- 36349748
OWN - NLM
STAT- MEDLINE
DCOM- 20230201
LR  - 20230421
IS  - 1096-9101 (Electronic)
IS  - 0196-8092 (Print)
IS  - 0196-8092 (Linking)
VI  - 55
IP  - 1
DP  - 2023 Jan
TI  - Laser therapy as a treatment for chronic radiation fibrosis.
PG  - 82-88
LID - 10.1002/lsm.23617 [doi]
AB  - BACKGROUND: Chronic radiation fibrosis (CRF) is a long-term sequala of radiation 
      therapy that has a significant impact on patient quality of life. There is no 
      standard of care or single therapeutic modality that has been found to be 
      consistently effective. OBJECTIVE: To describe our experience using fractional 
      10,600 nm carbon dioxide (CO(2) ) laser therapy and vascular laser therapy in a 
      series of patients with CRF. METHODS: Patients presenting to the dermatology 
      service for CRF were evaluated for laser therapy eligibility. Patients were 
      eligible if they had a clinical diagnosis of CRF confirmed by physical 
      examination. RESULTS: We identified five patients with CRF treated with 
      fractional ablative CO(2) laser and vascular laser. Patients were a median age of 
      57 years old, and the amount of time between the initiation of radiotherapy and 
      laser treatment ranged between 3 months and 40 years. The satisfactory response 
      was achieved in all cases. LIMITATIONS: Lack of standardized laser protocol, 
      small sample size, lack of a control group, different anatomical locations 
      CONCLUSION: Fractional ablative and vascular laser therapy may serve as an 
      additional treatment for CRF, leading to functional improvements.
CI  - (c) 2022 The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals 
      LLC.
FAU - Wilson, Britney
AU  - Wilson B
AUID- ORCID: 0000-0003-4680-5202
AD  - Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer 
      Center, New York, New York, USA.
FAU - Shah, Rohan
AU  - Shah R
AUID- ORCID: 0000-0002-6393-0657
AD  - Department of Dermatology, Rutgers New Jersey Medical School, Newark, New Jersey, 
      USA.
FAU - Menzer, Christian
AU  - Menzer C
AD  - Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer 
      Center, New York, New York, USA.
FAU - Aleisa, Abdullah
AU  - Aleisa A
AD  - Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer 
      Center, New York, New York, USA.
FAU - Rossi, Anthony
AU  - Rossi A
AUID- ORCID: 0000-0003-2295-1934
AD  - Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer 
      Center, New York, New York, USA.
AD  - Department of Dermatology, Weill Cornell Medicine, New York, New York, USA.
LA  - eng
GR  - P30 CA008748/CA/NCI NIH HHS/United States
PT  - Case Reports
PT  - Research Support, N.I.H., Extramural
DEP - 20221109
PL  - United States
TA  - Lasers Surg Med
JT  - Lasers in surgery and medicine
JID - 8007168
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Humans
MH  - Infant
MH  - Treatment Outcome
MH  - Radiation Fibrosis Syndrome
MH  - Carbon Dioxide
MH  - Quality of Life
MH  - *Laser Therapy/methods
MH  - *Lasers, Gas/therapeutic use
PMC - PMC10099494
OTO - NOTNLM
OT  - KTP laser
OT  - cancer therapy sequelae
OT  - chronic radiation fibrosis
OT  - fractional CO2 laser
OT  - radiation dermatitis
COIS- Dr. Anthony Rossi has no relevant conflicts of interest related to this 
      manuscript but has received grant funding from The Skin Cancer Foundation and the 
      A.Ward Ford Memorial Grant. He also served on advisory board, as a consultant, or 
      given educational presentations for Almirall; Allergan, Inc; Galderma Inc; Evolus 
      Inc; Elekta; Biofrontera, Quantia; Merz Inc; Dynamed; Skinuvia; Perf-Action; 
      Cutera; and LAM therapeutics. Dr. Christian Menzer is supported by a fellowship 
      from the German Research Foundation (DFG) (ME 5482/1-1). The remaining authors 
      declare no conflict of interest.
EDAT- 2022/11/10 06:00
MHDA- 2023/02/02 06:00
PMCR- 2023/04/13
CRDT- 2022/11/09 04:54
PHST- 2022/10/19 00:00 [revised]
PHST- 2022/03/26 00:00 [received]
PHST- 2022/10/19 00:00 [accepted]
PHST- 2022/11/10 06:00 [pubmed]
PHST- 2023/02/02 06:00 [medline]
PHST- 2022/11/09 04:54 [entrez]
PHST- 2023/04/13 00:00 [pmc-release]
AID - LSM23617 [pii]
AID - 10.1002/lsm.23617 [doi]
PST - ppublish
SO  - Lasers Surg Med. 2023 Jan;55(1):82-88. doi: 10.1002/lsm.23617. Epub 2022 Nov 9.