PMID- 36350412
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221116
IS  - 2662-8651 (Electronic)
IS  - 2662-8651 (Linking)
VI  - 3
IP  - 1
DP  - 2022 Nov 9
TI  - Predictive value of serum irisin for chronic heart failure in patients with type 
      2 diabetes mellitus.
PG  - 34
LID - 10.1186/s43556-022-00096-x [doi]
LID - 34
AB  - We hypothesize that serum irisin can have additional discriminative potency for 
      heart failure (HF) in individuals with type 2 diabetes mellitus (T2DM). The study 
      group comprised 226 consecutive T2DM patients (153 patients with any HF 
      phenotypes and 30 patients without HF) aged 41 to 65 years. The plasma levels 
      N-terminal brain natriuretic pro-peptide (NT-proBNP) and irisin were detected by 
      ELISA at the baseline of the study. We found that the most appropriate cut-off 
      value of irisin (HF versus non-HF) were 10.4 ng/mL (area under curve 
      [AUC] = 0.96, sensitivity = 81.0%, specificity = 88.0%; P = 0.0001). Cutoff point 
      of NT-proBNP that distinguished patients with HF and without it was 750 pmol/L 
      (AUC = 0.78; sensitivity = 72.7%, specificity 76.5%, p = 0.0001). Using 
      multivariate comparative analysis we established that concentrations of 
      irisin < 10.4 ng/mL (odds ration [OR] = 1.30; P = 0.001) and 
      NT-proBNP > 750 pmol/mL (OR = 1.17; P = 0.042), left atrial volume index 
      (LAVI) > 34 mL/m(2) (OR = 1.06; P = 0.042) independently predicted HF. Irisin 
      being added to NT-proBNP improved predictive modality for HF, whereas combination 
      of NT-proBNP and LAVI > 34 mL/m(2) did not. In conclusion, we established that 
      irisin had independent predicted potency for HF in patients with established 
      T2DM.
CI  - (c) 2022. The Author(s).
FAU - Berezin, Alexander A
AU  - Berezin AA
AUID- ORCID: 0000-0002-0660-9082
AD  - Zaporozhye Medical Academy of Postgraduate Education, 20, Vinter av., Zaporozhye, 
      69096, Ukraine.
FAU - Fushtey, Ivan M
AU  - Fushtey IM
AUID- ORCID: 0000-0001-5629-5264
AD  - Department of Therapy and Endocrinology, Zaporozhye Medical Academy of 
      Postgraduate Education, 20, Vinter av., Zaporozhye, 69096, Ukraine.
FAU - Pavlov, Sergii V
AU  - Pavlov SV
AUID- ORCID: 0000-0003-3924-4515
AD  - Department Clinical and Laboratory Diagnostics, Zaporozhye State Medical 
      University, 26, Mayakovsky av., Zaporozhye, 69035, Ukraine.
FAU - Berezin, Alexander E
AU  - Berezin AE
AUID- ORCID: 0000-0002-0446-3999
AD  - Therapeutic Unit, Internal Medicine Department, Zaporozhye State Medical 
      University, 26, Mayakovsky av., Zaporozhye, 69035, Ukraine. aeberezin@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20221109
PL  - Singapore
TA  - Mol Biomed
JT  - Molecular biomedicine
JID - 9918283581406676
PMC - PMC9646681
OTO - NOTNLM
OT  - Heart failure
OT  - Irisin
OT  - Natriuretic peptides
OT  - Predictive model
OT  - Type 2 diabetes mellitus
COIS- The authors declare no potential conflict of interest.
EDAT- 2022/11/10 06:00
MHDA- 2022/11/10 06:01
PMCR- 2022/11/09
CRDT- 2022/11/09 11:16
PHST- 2022/06/24 00:00 [received]
PHST- 2022/10/11 00:00 [accepted]
PHST- 2022/11/09 11:16 [entrez]
PHST- 2022/11/10 06:00 [pubmed]
PHST- 2022/11/10 06:01 [medline]
PHST- 2022/11/09 00:00 [pmc-release]
AID - 10.1186/s43556-022-00096-x [pii]
AID - 96 [pii]
AID - 10.1186/s43556-022-00096-x [doi]
PST - epublish
SO  - Mol Biomed. 2022 Nov 9;3(1):34. doi: 10.1186/s43556-022-00096-x.