PMID- 36352469
OWN - NLM
STAT- MEDLINE
DCOM- 20221111
LR  - 20221222
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 21
IP  - 1
DP  - 2022 Nov 9
TI  - Impact of T2DM on right ventricular systolic dysfunction and interventricular 
      interactions in patients with essential hypertension: evaluation using CMR tissue 
      tracking.
PG  - 238
LID - 10.1186/s12933-022-01678-3 [doi]
LID - 238
AB  - BACKGROUND: Previous studies reported that there was right ventricular (RV) 
      systolic dysfunction in patients with hypertension. The aim of this study was to 
      evaluate the impact of type 2 diabetes mellitus (T2DM) on RV systolic dysfunction 
      and interventricular interactions using cardiac magnetic resonance feature 
      tracking (CMR-FT) in patients with essential hypertension. METHODS AND METHODS: 
      Eighty-five hypertensive patients without T2DM [HTN(T2DM -)], 58 patients with 
      T2DM [HTN(T2DM +)] and 49 normal controls were included in this study. The 
      biventricular global radial, circumferential and longitudinal peak strains (GRS, 
      GCS, GLS, respectively) and RV regional strains at the basal-, mid- and 
      apical-cavity, were calculated with CMR-FT and compared among controls and 
      different patient groups. Backward stepwise multivariable linear regression 
      analyses were used to determine the effects of T2DM and left ventricular (LV) 
      strains on RV strains. RESULTS: The biventricular GLS and RV apical longitudinal 
      strain deteriorated significantly from controls, through HTN(T2DM-), to 
      HTN(T2DM +) groups. RV middle longitudinal strain in patient groups were 
      significantly reduced, and LV GRS and GCS and RV basal longitudinal strain were 
      decreased in HTN(T2DM +) but preserved in HTN(T2DM-) group. Multivariable 
      regression analyses adjusted for covariates demonstrated that T2DM was 
      independently associated with LV strains (LV GRS: beta = - 4.278, p = 0.004, model 
      R(2) = 0.285; GCS: beta = 1.498, p = 0.006, model R(2) = 0.363; GLS: beta = 1.133, 
      p = 0.007, model R(2) = 0.372) and RV GLS (beta = 1.454, p = 0.003, model 
      R(2) = 0.142) in hypertension. When T2DM and LV GLS were included in the multiple 
      regression analysis, both T2DM and LV GLS (beta = 0.977 and 0.362, p = 0.039 
      and < 0.001, model R(2) = 0.224) were independently associated with RV GLS. 
      CONCLUSIONS: T2DM exacerbates RV systolic dysfunction in patients with 
      hypertension, which may be associated with superimposed LV dysfunction by 
      coexisting T2DM and suggests adverse interventricular interactions.
CI  - (c) 2022. The Author(s).
FAU - Li, Xue-Ming
AU  - Li XM
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
AD  - Laboratory of Cardiovascular Diseases, Regenerative Medicine Research Center, 
      West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, 610041, 
      Sichuan, People's Republic of China.
FAU - Yan, Wei-Feng
AU  - Yan WF
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
FAU - Jiang, Li
AU  - Jiang L
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
FAU - Shi, Ke
AU  - Shi K
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
FAU - Ren, Yan
AU  - Ren Y
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, 37# Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of 
      China.
FAU - Han, Pei-Lun
AU  - Han PL
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
FAU - Peng, Li-Qing
AU  - Peng LQ
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
FAU - Guo, Ying-Kun
AU  - Guo YK
AD  - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of 
      Women and Children of Ministry of Education, West China Second University 
      Hospital, Sichuan University, 20# South Renmin Road, Chengdu, 610041, Sichuan, 
      People's Republic of China.
FAU - Yang, Zhi-Gang
AU  - Yang ZG
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, People's Republic of China. yangzg666@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221109
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis
MH  - Essential Hypertension/complications/diagnosis
MH  - *Ventricular Dysfunction, Left/diagnostic imaging/etiology
MH  - *Cardiomyopathies
MH  - *Hypertension/complications/diagnosis
MH  - Ventricular Function, Left
MH  - *Ventricular Dysfunction, Right/diagnostic imaging/etiology
MH  - Magnetic Resonance Imaging, Cine/methods
PMC - PMC9647910
OTO - NOTNLM
OT  - Hypertension
OT  - Interventricular coupling
OT  - Left ventricle
OT  - Magnetic resonance imaging
OT  - Right ventricle
OT  - Strain
OT  - Systolic dysfunction
OT  - Type 2 diabetes
COIS- The authors declare that there are no conflicts of interest.
EDAT- 2022/11/11 06:00
MHDA- 2022/11/15 06:00
PMCR- 2022/11/09
CRDT- 2022/11/10 00:11
PHST- 2022/08/05 00:00 [received]
PHST- 2022/10/26 00:00 [accepted]
PHST- 2022/11/10 00:11 [entrez]
PHST- 2022/11/11 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/11/09 00:00 [pmc-release]
AID - 10.1186/s12933-022-01678-3 [pii]
AID - 1678 [pii]
AID - 10.1186/s12933-022-01678-3 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2022 Nov 9;21(1):238. doi: 10.1186/s12933-022-01678-3.