PMID- 36352848
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221111
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - The new mechanism of cognitive decline induced by hypertension: High 
      homocysteine-mediated aberrant DNA methylation.
PG  - 928701
LID - 10.3389/fcvm.2022.928701 [doi]
LID - 928701
AB  - The prevalence and severity of hypertension-induced cognitive impairment increase 
      with the prolonging of hypertension. The mechanisms of cognitive impairment 
      induced by hypertension primarily include cerebral blood flow perfusion 
      imbalance, white and gray matter injury with blood-brain barrier disruption, 
      neuroinflammation and amyloid-beta deposition, genetic polymorphisms and 
      variants, and instability of blood pressure. High homocysteine (HHcy) is an 
      independent risk factor for hypertension that also increases the risk of 
      developing early cognitive impairment. Homocysteine (Hcy) levels increase in 
      patients with cognitive impairment induced by hypertension. This review 
      summarizes a new mechanism whereby HHcy-mediated aberrant DNA methylation and 
      exacerbate hypertension. It involves changes in Hcy-dependent DNA methylation 
      products, such as methionine adenosyltransferase, DNA methyltransferases, 
      S-adenosylmethionine, S-adenosylhomocysteine, and methylenetetrahydrofolate 
      reductase (MTHFR). The mechanism also involves DNA methylation changes in the 
      genes of hypertension patients, such as brain-derived neurotrophic factor, 
      apolipoprotein E4, and estrogen receptor alpha, which contribute to learning, 
      memory, and attention deficits. Studies have shown that methionine (Met) induces 
      hypertension in mice. Moreover, DNA hypermethylation leads to cognitive 
      behavioral changes alongside oligodendroglial and/or myelin deficits in 
      Met-induced mice. Taken together, these studies demonstrate that DNA methylation 
      regulates cognitive dysfunction in patients with hypertension. A better 
      understanding of the function and mechanism underlying the effect of 
      Hcy-dependent DNA methylation on hypertension-induced cognitive impairment will 
      be valuable for early diagnosis, interventions, and prevention of further 
      cognitive defects induced by hypertension.
CI  - Copyright (c) 2022 Wan, Zong and Chen.
FAU - Wan, Chong
AU  - Wan C
AD  - Department of Military Medical Geography, Army Medical Training Base, Army 
      Medical University (Third Military Medical University), Chongqing, China.
AD  - College of Basic Medicine, Army Medical University, Chongqing, China.
FAU - Zong, Rui-Yi
AU  - Zong RY
AD  - Department of Military Medical Geography, Army Medical Training Base, Army 
      Medical University (Third Military Medical University), Chongqing, China.
AD  - NCO School, Army Medical University, Shijiazhuang, China.
FAU - Chen, Xing-Shu
AU  - Chen XS
AD  - Department of Military Medical Geography, Army Medical Training Base, Army 
      Medical University (Third Military Medical University), Chongqing, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221024
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9637555
OTO - NOTNLM
OT  - DNA methylation
OT  - Hcy
OT  - Met
OT  - cognition decline
OT  - hypertension
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/11 06:00
MHDA- 2022/11/11 06:01
PMCR- 2022/01/01
CRDT- 2022/11/10 02:04
PHST- 2022/04/26 00:00 [received]
PHST- 2022/09/30 00:00 [accepted]
PHST- 2022/11/10 02:04 [entrez]
PHST- 2022/11/11 06:00 [pubmed]
PHST- 2022/11/11 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.928701 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Oct 24;9:928701. doi: 10.3389/fcvm.2022.928701. 
      eCollection 2022.