PMID- 36353573
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221111
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 13
DP  - 2022
TI  - Abnormal percent amplitude of fluctuation changes in patients with monocular 
      blindness: A resting-state functional magnetic resonance imaging study.
PG  - 942905
LID - 10.3389/fpsyt.2022.942905 [doi]
LID - 942905
AB  - PURPOSE: Previous studies on monocular blindness (MB) have mainly focused on 
      concept and impact. The present study measured spontaneous brain activity in MB 
      patients using the percentage of amplitude fluctuation (PerAF) method. METHODS: 
      Twenty-nine patients with MB (21 male and 8 female) and 29 age-, gender-, and 
      weight-matched healthy controls (HCs) were recruited. All participants underwent 
      resting state functional magnetic resonance imaging (rs-fMRI). The PerAF method 
      was used to analyze the data and evaluate the spontaneous regional brain 
      activity. The ability of PerAF values to distinguish patients with MB from HCs 
      was analyzed using receiver operating characteristic (ROC) curves, and 
      correlation analysis was used to assess the relationship between PerAF values of 
      brain regions and the Hospital Anxiety and Depression Scale (HADS) scores. 
      RESULTS: PerAF values in Occipital_Mid_L/Occipital_Mid_R/Cingulum_ Mid_L were 
      significantly lower in patients with MB than in controls. Conversely, values in 
      the Frontal_Sup_Orb_L/Frontal_Inf_Orb_L/Temporal _Inf_L/Frontal_Inf_Oper_L were 
      significantly higher in MB patients than in HCs. And the AUC of ROC curves were 
      follows: 0.904, (p < 0.0001; 95%CI: 0.830-0.978) for 
      Frontal_Sup_Orb_L/Frontal_Inf_Orb_L; Temporal_Inf_L 0.883, (p < 0.0001; 95% CI: 
      0.794-0.972); Frontal_Inf_Oper_L 0.964, (p < 0.0001; 95% CI: 0.924-1.000), and 
      0.893 (p < 0.0001; 95% CI: 0.812-0.973) for Occipital_Mid_L; Occipital_Mid_R 
      0.887, (p < 0.0001; 95% CI: 0.802-0.971); Cingulum_Mid_L 0.855, (p < 0.0001; 95% 
      CI: 0.750-0.960). CONCLUSION: The results of our study show abnormal activity in 
      some brain regions in patients with MB, indicating that these patients may be at 
      risk of disorder related to these brain regions. These results may reflect the 
      neuropathological mechanisms of MB and facilitate early MB diagnoses.
CI  - Copyright (c) 2022 Hu, Chen, Kang, Ying, Liao, Zou, Su, Wang, Wei and Shao.
FAU - Hu, Qiaohao
AU  - Hu Q
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Branch of National Clinical Research Center for Ocular 
      Disease, Nanchang, China.
FAU - Chen, Jun
AU  - Chen J
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Branch of National Clinical Research Center for Ocular 
      Disease, Nanchang, China.
FAU - Kang, Min
AU  - Kang M
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Branch of National Clinical Research Center for Ocular 
      Disease, Nanchang, China.
FAU - Ying, Ping
AU  - Ying P
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Branch of National Clinical Research Center for Ocular 
      Disease, Nanchang, China.
FAU - Liao, Xulin
AU  - Liao X
AD  - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong 
      Kong, Shatin, Hong Kong SAR, China.
FAU - Zou, Jie
AU  - Zou J
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Branch of National Clinical Research Center for Ocular 
      Disease, Nanchang, China.
FAU - Su, Ting
AU  - Su T
AD  - Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 
      Boston, MA, United States.
FAU - Wang, Yixin
AU  - Wang Y
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Branch of National Clinical Research Center for Ocular 
      Disease, Nanchang, China.
FAU - Wei, Hong
AU  - Wei H
AD  - School of Optometry and Vision Sciences, College of Biomedical and Life Sciences, 
      Cardiff University, Cardiff, United Kingdom.
FAU - Shao, Yi
AU  - Shao Y
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Branch of National Clinical Research Center for Ocular 
      Disease, Nanchang, China.
LA  - eng
PT  - Journal Article
DEP - 20221024
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC9637563
OTO - NOTNLM
OT  - MB
OT  - PerAF
OT  - fluctuation changes
OT  - functional magnetic resonance imaging
OT  - resting state
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/11 06:00
MHDA- 2022/11/11 06:01
PMCR- 2022/10/24
CRDT- 2022/11/10 02:22
PHST- 2022/05/13 00:00 [received]
PHST- 2022/08/08 00:00 [accepted]
PHST- 2022/11/10 02:22 [entrez]
PHST- 2022/11/11 06:00 [pubmed]
PHST- 2022/11/11 06:01 [medline]
PHST- 2022/10/24 00:00 [pmc-release]
AID - 10.3389/fpsyt.2022.942905 [doi]
PST - epublish
SO  - Front Psychiatry. 2022 Oct 24;13:942905. doi: 10.3389/fpsyt.2022.942905. 
      eCollection 2022.