PMID- 36354165
OWN - NLM
STAT- MEDLINE
DCOM- 20230106
LR  - 20230127
IS  - 1613-6829 (Electronic)
IS  - 1613-6810 (Linking)
VI  - 19
IP  - 1
DP  - 2023 Jan
TI  - Microalgae-Based Biohybrid Microrobot for Accelerated Diabetic Wound Healing.
PG  - e2204617
LID - 10.1002/smll.202204617 [doi]
AB  - A variety of wound healing platforms have been proposed to alleviate the hypoxic 
      condition and/or to modulate the immune responses for the treatment of chronic 
      wounds in diabetes. However, these platforms with the passive diffusion of 
      therapeutic agents through the blood clot result in the relatively low delivery 
      efficiency into the deep wound site. Here, a microalgae-based biohybrid 
      microrobot for accelerated diabetic wound healing is developed. The biohybrid 
      microrobot autonomously moves at velocity of 33.3 microm s(-1) and generates oxygen 
      for the alleviation of hypoxic condition. In addition, the microrobot efficiently 
      bound with inflammatory chemokines of interleukin-8 (IL-8) and monocyte 
      chemoattractant protein-1 (MCP-1) for modulating the immune responses. The 
      enhanced penetration of microrobot is corroborated by measuring fibrin clots in 
      biomimetic wound using microfluidic devices and the enhanced retention of 
      microrobot is confirmed in the real wounded mouse skin tissue. After deposition 
      on the chronic wound in diabetic mice without wound dressing, the wounds treated 
      with microrobots are completely healed after 9 days with the significant decrease 
      of inflammatory cytokines below 31% of the control level and the upregulated 
      angiogenesis above 20 times of CD31(+) cells. These results confirm the 
      feasibility of microrobots as a next-generation platform for diabetic wound 
      healing.
CI  - (c) 2022 Wiley-VCH GmbH.
FAU - Choi, Hyunsik
AU  - Choi H
AD  - Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of 
      Science and Technology (BIST), Barcelona, 08028, Spain.
AD  - PHI BIOMED Co., 168, Yeoksam-ro, Gangnam-gu, Seoul, 06248, Korea.
FAU - Kim, Bolam
AU  - Kim B
AD  - School of Chemical Engineering and Institute of Environment & Energy, Pusan 
      National University, Busan, 46241, Korea.
FAU - Jeong, Sang Hoon
AU  - Jeong SH
AD  - Department of Materials Science and Engineering, Pohang University of Science and 
      Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, Korea.
FAU - Kim, Tae Yeon
AU  - Kim TY
AD  - Department of Materials Science and Engineering, Pohang University of Science and 
      Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, Korea.
FAU - Kim, Dong-Pyo
AU  - Kim DP
AD  - Department of Chemical Engineering, Pohang University of Science and Technology 
      (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, Korea.
FAU - Oh, You-Kwan
AU  - Oh YK
AD  - School of Chemical Engineering and Institute of Environment & Energy, Pusan 
      National University, Busan, 46241, Korea.
FAU - Hahn, Sei Kwang
AU  - Hahn SK
AUID- ORCID: 0000-0002-7718-6259
AD  - PHI BIOMED Co., 168, Yeoksam-ro, Gangnam-gu, Seoul, 06248, Korea.
AD  - Department of Materials Science and Engineering, Pohang University of Science and 
      Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221110
PL  - Germany
TA  - Small
JT  - Small (Weinheim an der Bergstrasse, Germany)
JID - 101235338
RN  - 0 (Cytokines)
SB  - IM
MH  - Mice
MH  - Animals
MH  - *Microalgae/metabolism
MH  - *Diabetes Mellitus, Experimental
MH  - Wound Healing/physiology
MH  - Skin/metabolism
MH  - Cytokines/metabolism
OTO - NOTNLM
OT  - algae
OT  - biohybrid
OT  - microrobots
OT  - polyions
OT  - wound healing
EDAT- 2022/11/11 06:00
MHDA- 2023/01/07 06:00
CRDT- 2022/11/10 07:12
PHST- 2022/10/17 00:00 [revised]
PHST- 2022/07/27 00:00 [received]
PHST- 2022/11/11 06:00 [pubmed]
PHST- 2023/01/07 06:00 [medline]
PHST- 2022/11/10 07:12 [entrez]
AID - 10.1002/smll.202204617 [doi]
PST - ppublish
SO  - Small. 2023 Jan;19(1):e2204617. doi: 10.1002/smll.202204617. Epub 2022 Nov 10.