PMID- 36354493 OWN - NLM STAT- MEDLINE DCOM- 20221114 LR - 20230328 IS - 2079-6374 (Electronic) IS - 2079-6374 (Linking) VI - 12 IP - 11 DP - 2022 Nov 7 TI - Angiotensin-Converting Enzyme 2-Based Biosensing Modalities and Devices for Coronavirus Detection. LID - 10.3390/bios12110984 [doi] LID - 984 AB - Rapid and cost-effective diagnostic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are a critical and valuable weapon for the coronavirus disease 2019 (COVID-19) pandemic response. SARS-CoV-2 invasion is primarily mediated by human angiotensin-converting enzyme 2 (hACE2). Recent developments in ACE2-based SARS-CoV-2 detection modalities accentuate the potential of this natural host-virus interaction for developing point-of-care (POC) COVID-19 diagnostic systems. Although research on harnessing ACE2 for SARS-CoV-2 detection is in its infancy, some interesting biosensing devices have been developed, showing the commercial viability of this intriguing new approach. The exquisite performance of the reported ACE2-based COVID-19 biosensors provides opportunities for researchers to develop rapid detection tools suitable for virus detection at points of entry, workplaces, or congregate scenarios in order to effectively implement pandemic control and management plans. However, to be considered as an emerging approach, the rationale for ACE2-based biosensing needs to be critically and comprehensively surveyed and discussed. Herein, we review the recent status of ACE2-based detection methods, the signal transduction principles in ACE2 biosensors and the development trend in the future. We discuss the challenges to development of ACE2-biosensors and delineate prospects for their use, along with recommended solutions and suggestions. FAU - Gul, Ijaz AU - Gul I AUID- ORCID: 0000-0002-2929-137X AD - Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. AD - Tsinghua-Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. FAU - Zhai, Shiyao AU - Zhai S AD - Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. AD - Tsinghua-Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. FAU - Zhong, Xiaoyun AU - Zhong X AD - Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. AD - Tsinghua-Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. FAU - Chen, Qun AU - Chen Q AD - Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. AD - Tsinghua-Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. FAU - Yuan, Xi AU - Yuan X AD - Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. AD - Tsinghua-Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. FAU - Du, Zhicheng AU - Du Z AD - Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. AD - Tsinghua-Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. FAU - Chen, Zhenglin AU - Chen Z AD - Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. AD - Tsinghua-Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. FAU - Raheem, Muhammad Akmal AU - Raheem MA AD - Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. AD - Tsinghua-Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. FAU - Deng, Lin AU - Deng L AD - Shenzhen Bay Laboratory, Shenzhen 518132, China. FAU - Leeansyah, Edwin AU - Leeansyah E AUID- ORCID: 0000-0003-0505-4967 AD - Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. AD - Tsinghua-Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. FAU - Zhang, Can Yang AU - Zhang CY AUID- ORCID: 0000-0002-6975-5781 AD - Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. AD - Tsinghua-Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. FAU - Yu, Dongmei AU - Yu D AD - Department of Computer Science and Technology, School of Mechanical, Electrical & Information Engineering, Shandong University, Weihai 264209, China. FAU - Qin, Peiwu AU - Qin P AUID- ORCID: 0000-0002-7829-8973 AD - Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. AD - Tsinghua-Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. LA - eng GR - 31970752/National Natural Science Foundation of China/ GR - JCYJ20190809180003689, JSGG20200225150707332, JSGG20191129110812/Science, Technology, Innovation Commission of Shenzhen Municipality/ GR - SZBL2020090501004/Shenzhen Bay Laboratory/ PT - Journal Article PT - Review DEP - 20221107 PL - Switzerland TA - Biosensors (Basel) JT - Biosensors JID - 101609191 RN - EC 3.4.17.23 (Angiotensin-Converting Enzyme 2) RN - EC 3.4.15.1 (Peptidyl-Dipeptidase A) SB - IM MH - Humans MH - *Angiotensin-Converting Enzyme 2 MH - *COVID-19/diagnosis MH - SARS-CoV-2 MH - Peptidyl-Dipeptidase A/physiology MH - Pandemics PMC - PMC9688389 OTO - NOTNLM OT - ACE2 biosensors OT - COVID-19 OT - SARS-CoV-2 OT - colorimetric sensors OT - electrochemical detection OT - low-cost diagnostic COIS- The authors declare no conflict of interest. EDAT- 2022/11/11 06:00 MHDA- 2022/11/15 06:00 PMCR- 2022/11/07 CRDT- 2022/11/10 09:33 PHST- 2022/09/28 00:00 [received] PHST- 2022/11/02 00:00 [revised] PHST- 2022/11/03 00:00 [accepted] PHST- 2022/11/10 09:33 [entrez] PHST- 2022/11/11 06:00 [pubmed] PHST- 2022/11/15 06:00 [medline] PHST- 2022/11/07 00:00 [pmc-release] AID - bios12110984 [pii] AID - biosensors-12-00984 [pii] AID - 10.3390/bios12110984 [doi] PST - epublish SO - Biosensors (Basel). 2022 Nov 7;12(11):984. doi: 10.3390/bios12110984.