PMID- 36354499
OWN - NLM
STAT- MEDLINE
DCOM- 20221114
LR  - 20221126
IS  - 2079-6374 (Electronic)
IS  - 2079-6374 (Linking)
VI  - 12
IP  - 11
DP  - 2022 Nov 8
TI  - Sensitive Electrochemical Detection of 4-Nitrophenol with PEDOT:PSS Modified Pt 
      NPs-Embedded PPy-CB@ZnO Nanocomposites.
LID - 10.3390/bios12110990 [doi]
LID - 990
AB  - In this study, a selective 4-nitrophenol (4-NP) sensor was developed onto a 
      glassy carbon electrode (GCE) as an electron-sensing substrate, which decorated 
      with sol-gel, prepared Pt nanoparticles- (NPs) embedded polypyrole-carbon black 
      (PPy-CB)/ZnO nanocomposites (NCs) using differential pulse voltammetry. 
      Characterizations of the NCs were performed using Field Emission Scanning 
      Electron Microscopy (FESEM), Energy-Dispersive Spectroscopy (EDS), X-ray 
      Photoelectron Spectroscopy (XPS), Ultraviolet-visible Spectroscopy (UV-vis), 
      Fourier Transform Infrared Spectroscopy (FTIR), High Resolution Transmission 
      Electron Microscopy (HRTEM), and X-ray Diffraction Analysis (XRD). The GCE 
      modified by conducting coating binders [poly(3,4-ethylenedioxythiophene) 
      polystyrene sulfonate; PEDOT:PSS] based on Pt NPs/PPy-CB/ZnO NCs functioned as 
      the working electrode and showed selectivity toward 4-NP in a phosphate buffer 
      medium at pH 7.0. Our analysis of 4-NP showed the linearity from 1.5 to 40.5 microM, 
      which was identified as the linear detection range (LDR). A current versus 
      concentration plot was formed and showed a regression co-efficient R(2) of 
      0.9917, which can be expressed by i(p)(microA) = 0.2493C(microM) + 15.694. The 4-NP 
      sensor sensitivity was calculated using the slope of the LDR, considering the 
      surface area of the GCE (0.0316 cm(2)). The sensitivity was calculated as 7.8892 
      microAmicroM(-1)cm(-2). The LOD (limit of detection) of the 4-NP was calculated as 1.25 +/- 
      0.06 microM, which was calculated from 3xSD/sigma (SD: Standard deviation of blank 
      response; sigma: Slope of the calibration curve). Limit of quantification (LOQ) is 
      also calculated as 3.79 microM from LOQ = 10xLOD/3.3. Sensor parameters such as 
      reproducibility, response time, and analyzing stability were outstanding. 
      Therefore, this novel approach can be broadly used to safely fabricate selective 
      4-NP sensors based on nanoparticle-decorated nanocomposite materials in 
      environmental measurement.
FAU - Faisal, Mohd
AU  - Faisal M
AD  - Promising Centre for Sensors and Electronic Devices (PCSED), Advanced Materials 
      and Nano-Research Centre, Najran University, P.O. Box 1988, Najran 11001, Saudi 
      Arabia.
AD  - Department of Chemistry, Faculty of Science and Arts, Najran University, Najran 
      11001, Saudi Arabia.
FAU - Alam, Md Mahmud
AU  - Alam MM
AUID- ORCID: 0000-0002-2636-5038
AD  - Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz 
      University, Jeddah 21589, Saudi Arabia.
FAU - Ahmed, Jahir
AU  - Ahmed J
AD  - Promising Centre for Sensors and Electronic Devices (PCSED), Advanced Materials 
      and Nano-Research Centre, Najran University, P.O. Box 1988, Najran 11001, Saudi 
      Arabia.
FAU - Asiri, Abdullah M
AU  - Asiri AM
AUID- ORCID: 0000-0001-7905-3209
AD  - Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz 
      University, Jeddah 21589, Saudi Arabia.
AD  - Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah 
      21589, Saudi Arabia.
FAU - Jalalah, Mohammed
AU  - Jalalah M
AUID- ORCID: 0000-0002-6828-3874
AD  - Promising Centre for Sensors and Electronic Devices (PCSED), Advanced Materials 
      and Nano-Research Centre, Najran University, P.O. Box 1988, Najran 11001, Saudi 
      Arabia.
AD  - Department of Electrical Engineering, College of Engineering, Najran University, 
      Najran 11001, Saudi Arabia.
FAU - Alruwais, Raja Saad
AU  - Alruwais RS
AD  - Chemistry Department, Faculty of Science and Humanities, Shaqra University, 
      Dawadmi 17472, Saudi Arabia.
FAU - Rahman, Mohammed M
AU  - Rahman MM
AUID- ORCID: 0000-0003-2773-1244
AD  - Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz 
      University, Jeddah 21589, Saudi Arabia.
AD  - Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah 
      21589, Saudi Arabia.
FAU - Harraz, Farid A
AU  - Harraz FA
AUID- ORCID: 0000-0001-7776-7099
AD  - Promising Centre for Sensors and Electronic Devices (PCSED), Advanced Materials 
      and Nano-Research Centre, Najran University, P.O. Box 1988, Najran 11001, Saudi 
      Arabia.
AD  - Department of Chemistry, Faculty of Science and Arts at Sharurah, Najran 
      University, Najran 11001, Saudi Arabia.
LA  - eng
GR  - NU/RG/SERC/11/18/Deanship of Scienti fi c Research at Najran University/
PT  - Journal Article
DEP - 20221108
PL  - Switzerland
TA  - Biosensors (Basel)
JT  - Biosensors
JID - 101609191
RN  - 0 (poly(3,4-ethylene dioxythiophene))
RN  - Y92ZL45L4R (4-nitrophenol)
RN  - SOI2LOH54Z (Zinc Oxide)
RN  - 0 (Soot)
RN  - 7440-44-0 (Carbon)
SB  - IM
MH  - *Zinc Oxide/chemistry
MH  - Soot
MH  - Reproducibility of Results
MH  - Limit of Detection
MH  - Electrodes
MH  - *Nanoparticles/chemistry
MH  - Carbon/chemistry
PMC - PMC9688362
OTO - NOTNLM
OT  - 4-nitrophenol detection
OT  - Pt-NPs-embedded PPy-CB/ZnO nanocomposites
OT  - differential pulse voltammetry
OT  - environmental safety
OT  - glassy carbon electrode
COIS- The authors declare no conflict of interest.
EDAT- 2022/11/11 06:00
MHDA- 2022/11/15 06:00
PMCR- 2022/11/08
CRDT- 2022/11/10 09:33
PHST- 2022/09/25 00:00 [received]
PHST- 2022/11/05 00:00 [revised]
PHST- 2022/11/06 00:00 [accepted]
PHST- 2022/11/10 09:33 [entrez]
PHST- 2022/11/11 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/11/08 00:00 [pmc-release]
AID - bios12110990 [pii]
AID - biosensors-12-00990 [pii]
AID - 10.3390/bios12110990 [doi]
PST - epublish
SO  - Biosensors (Basel). 2022 Nov 8;12(11):990. doi: 10.3390/bios12110990.