PMID- 36355101
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230921
IS  - 2218-1989 (Print)
IS  - 2218-1989 (Electronic)
IS  - 2218-1989 (Linking)
VI  - 12
IP  - 11
DP  - 2022 Oct 25
TI  - A Novel Ketone-Supplemented Diet Improves Recognition Memory and Hippocampal 
      Mitochondrial Efficiency in Healthy Adult Mice.
LID - 10.3390/metabo12111019 [doi]
LID - 1019
AB  - Mitochondrial dysfunction and cognitive impairment are common symptoms in many 
      neurologic and psychiatric disorders, as well as nonpathological aging. Ketones 
      have been suggested as therapeutic for their efficacy in epilepsy and other brain 
      pathologies such as Alzheimer's disease and major depressive disorder. However, 
      their effects on cognitive function in healthy individuals is less established. 
      Here, we explored the mitochondrial and performative outcomes of a novel 
      eight-week ketone-supplemented ketogenic (KETO) diet in healthy adult male and 
      female mice. In a novel object recognition test, KETO mice spent more time with 
      the novel, compared to familiar, object, indicating an improvement in recognition 
      memory. High-resolution respirometry on permeabilized hippocampal tissue returned 
      significant reductions in mitochondrial O(2) consumption. No changes in ATP 
      production were observed, yielding a significantly higher ATP:O(2) ratio, a 
      measure of mitochondrial efficiency. Together, these findings demonstrate the 
      KETO diet improves hippocampal mitochondrial efficiency. They add to a growing 
      body of evidence that suggests ketones and ketogenic diets are neuroprotective 
      and metabolically and cognitively relevant, even in healthy adults. They also 
      suggest that ketogenic lifestyle changes may be effective strategies for 
      protecting against cognitive decline associated with aging and disease.
FAU - Saito, Erin R
AU  - Saito ER
AUID- ORCID: 0000-0003-1649-4722
AD  - Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 
      84602, USA.
FAU - Warren, Cali E
AU  - Warren CE
AD  - Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 
      84602, USA.
FAU - Hanegan, Cameron M
AU  - Hanegan CM
AUID- ORCID: 0000-0003-2956-7118
AD  - Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 
      84602, USA.
FAU - Larsen, John G
AU  - Larsen JG
AD  - Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 
      84602, USA.
FAU - du Randt, Johannes D
AU  - du Randt JD
AD  - Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 
      84602, USA.
FAU - Cannon, Mio
AU  - Cannon M
AD  - Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 
      84602, USA.
FAU - Saito, Jeremy Y
AU  - Saito JY
AD  - Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 
      84602, USA.
FAU - Campbell, Rachel J
AU  - Campbell RJ
AD  - Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 
      84602, USA.
FAU - Kemberling, Colin M
AU  - Kemberling CM
AD  - Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 
      84602, USA.
FAU - Miller, Gavin S
AU  - Miller GS
AD  - Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 
      84602, USA.
FAU - Edwards, Jeffrey G
AU  - Edwards JG
AUID- ORCID: 0000-0001-7298-1889
AD  - Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 
      84602, USA.
FAU - Bikman, Benjamin T
AU  - Bikman BT
AD  - Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 
      84602, USA.
LA  - eng
GR  - R15 DA049260/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20221025
PL  - Switzerland
TA  - Metabolites
JT  - Metabolites
JID - 101578790
PMC - PMC9693360
OTO - NOTNLM
OT  - hippocampus
OT  - ketogenic diet
OT  - metabolism
OT  - mitochondrial efficiency
OT  - recognition memory
COIS- B.T.B. is a co-owner of HLTH Code and receives royalties from the sale of a book 
      about insulin resistance. All other authors declare that they have no conflicts 
      of interest. The funders had no role in the design of the study; in the 
      collection, analyses, or interpretation of the data; in the writing of the 
      manuscript; or in the decision to publish the results.
EDAT- 2022/11/11 06:00
MHDA- 2022/11/11 06:01
PMCR- 2022/10/25
CRDT- 2022/11/10 11:14
PHST- 2022/09/06 00:00 [received]
PHST- 2022/10/20 00:00 [revised]
PHST- 2022/10/21 00:00 [accepted]
PHST- 2022/11/10 11:14 [entrez]
PHST- 2022/11/11 06:00 [pubmed]
PHST- 2022/11/11 06:01 [medline]
PHST- 2022/10/25 00:00 [pmc-release]
AID - metabo12111019 [pii]
AID - metabolites-12-01019 [pii]
AID - 10.3390/metabo12111019 [doi]
PST - epublish
SO  - Metabolites. 2022 Oct 25;12(11):1019. doi: 10.3390/metabo12111019.