PMID- 36355242
OWN - NLM
STAT- MEDLINE
DCOM- 20230314
LR  - 20240208
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Print)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 10
DP  - 2023 Feb
TI  - Ameliorative role of nanocurcumin against the toxicological effects of novel 
      forms of Cuo as nanopesticides: a comparative study.
PG  - 26270-26291
LID - 10.1007/s11356-022-23886-w [doi]
AB  - Copper oxide nanoparticles (CuONPs) have a wide range of uses in agricultural 
      applications. Nanocurcumin (NCur) acts as an antioxidant treatment. The goal of 
      the study is to reduce the toxicity resulting from the use of CuONPs as 
      nanopesticides on living organisms by inducing changes in the morphological shape 
      of CuONPs or treating it with NCur. So, we induced a comparative study between 
      three shapes of CuONPs: CuO nanosphere (CuONSp), CuO nanosheet (CuONS), and CuO 
      nanoflower (CuONF). We characterize each nano-form by using X-ray diffraction 
      (XRD), scanning electron microscope (SEM), transmission electron microscope 
      (HRTEM), and Zetasizer HT device; 36 rats were divided into six groups (n = 6): 
      1st group was the control group; 2nd group received 50 mg/kg/day of NCur orally 
      for 30 days; 3rd, 4th, and 5th groups received orally 50 mg/kg/day of CuONSp, 
      CuONS, and CuONF, respectively, for 30 days; 6th group received 50 mg/kg/day 
      CuONSp plus 50 mg/kg/day of NCur orally for 30 days. An elevation occurred in 
      malondialdehyde (MDA), liver and kidney functions, tumor necrosis factor-alpha 
      (TNF-alpha), and B-cell lymphoma 2 (Bcl2) by CuONSp > CuONS > CuONF, respectively. An 
      inhibition occurred in glutathione (GSH), superoxidase (SOD) catalase (CAT), 
      apoptotic Bax gene (Bax), histopathological, and ultrastructural alterations by 
      CuONSp < CuONS < CuONF, respectively. NCur ameliorated these alternations. In 
      conclusion, CuONF is a better form compared to other forms of nanopesticide in 
      agriculture due to its lower toxicity. NCur decreased the biological alternations 
      which induced by CuONSp due to its antioxidant and anti-apoptotic properties.
CI  - (c) 2022. The Author(s).
FAU - Abdel-Azeem, Abeer M
AU  - Abdel-Azeem AM
AD  - Cell Biology, Histology and Genetics Division, Zoology Department, Faculty of 
      Science, Beni-Suef University, P.O. BOX 62521, Beni-Suef, Egypt.
FAU - Abdel-Rehiem, Eman S
AU  - Abdel-Rehiem ES
AD  - Molecular Physiology Division, Zoology Department, Faculty of Science, Beni-Suef 
      University, P.O. Box 62521, Beni-Suef, Egypt.
FAU - Farghali, Ahmed A
AU  - Farghali AA
AD  - Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies 
      for Advanced Sciences, Beni-Suef University, P.O. Box 62511, Beni-Suef, Egypt.
FAU - Khidr, Fatma K
AU  - Khidr FK
AD  - Animal Research Department, Plant Protection Research Institute, Agricultural 
      Research Center, Cairo, Egypt.
FAU - Abdul-Hamid, Manal
AU  - Abdul-Hamid M
AUID- ORCID: 0000-0002-0877-3097
AD  - Cell Biology, Histology and Genetics Division, Zoology Department, Faculty of 
      Science, Beni-Suef University, P.O. BOX 62521, Beni-Suef, Egypt. 
      medo_bio@yahoo.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Retracted Publication
DEP - 20221110
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Antioxidants)
RN  - 0 (bcl-2-Associated X Protein)
RN  - 789U1901C5 (Copper)
RN  - V1XJQ704R4 (cupric oxide)
RN  - GAN16C9B8O (Glutathione)
RN  - 0 (Pesticides)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
RIN - Environ Sci Pollut Res Int. 2024 Feb;31(9):14347. PMID: 38265597
MH  - Animals
MH  - Rats
MH  - *Antioxidants/pharmacology
MH  - bcl-2-Associated X Protein
MH  - *Copper/adverse effects/chemistry/toxicity
MH  - Glutathione/metabolism
MH  - Nanoparticles/adverse effects/chemistry/toxicity
MH  - Oxidative Stress
MH  - *Pesticides/adverse effects/chemistry/toxicity
MH  - Curcumin/pharmacology/therapeutic use
PMC - PMC9995535
OTO - NOTNLM
OT  - Apoptotic marker
OT  - CuONF
OT  - CuONS
OT  - CuONSp
OT  - Histopathological studies
COIS- The authors declare no competing interests.
EDAT- 2022/11/11 06:00
MHDA- 2023/03/11 06:00
PMCR- 2022/11/10
CRDT- 2022/11/10 11:19
PHST- 2022/07/21 00:00 [received]
PHST- 2022/10/25 00:00 [accepted]
PHST- 2022/11/11 06:00 [pubmed]
PHST- 2023/03/11 06:00 [medline]
PHST- 2022/11/10 11:19 [entrez]
PHST- 2022/11/10 00:00 [pmc-release]
AID - 10.1007/s11356-022-23886-w [pii]
AID - 23886 [pii]
AID - 10.1007/s11356-022-23886-w [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Feb;30(10):26270-26291. doi: 
      10.1007/s11356-022-23886-w. Epub 2022 Nov 10.