PMID- 36356461
OWN - NLM
STAT- MEDLINE
DCOM- 20221205
LR  - 20221205
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 157
DP  - 2022 Dec
TI  - Modic changes associated with greater pain relief following anesthetization of 
      the adjacent lumbar intervertebral disc: A retrospective study of chronic low 
      back pain patients.
PG  - 110589
LID - S0720-048X(22)00439-9 [pii]
LID - 10.1016/j.ejrad.2022.110589 [doi]
AB  - PURPOSE: To assess the correlation between the degree of pain relief following 
      discoblock and the presence and type of adjacent Modic changes (MC). METHOD: We 
      retrospectively analyzed chronic low back pain (LBP) patients whose pain was 
      suspected to originate from a specific lumbar intervertebral disc (IVD) based on 
      a spine orthopedist's clinical evaluation and magnetic resonance imaging (MRI). 
      Thus, patients were selected to undergo discoblock. We calculated the degree of 
      pain relief following discoblock on Numerical Rating Scale (DeltaNRS) and analyzed 
      the MRIs on the basis of MC presence and type on the lumbar spinal segment in 
      question. We assessed the differences in DeltaNRS between the groups with absent and 
      present MC and the groups of MC subtypes. RESULTS: Forty-five patients were 
      included in the present study, all of whom underwent discoblock at a single 
      level. The total MC prevalence was 77.8 % (35 patients); pure or dominant MC type 
      1 (MC1 group) 35.6 % (16 patients); and pure or dominant MC type 2 (MC2 group) 
      42.2 % (19 patients). DeltaNRS was significantly greater in the group with MC 
      compared to the group without MC (median DeltaNRS -5.0 vs -2.5, respectively, 
      P = 0.043). In pairwise comparisons, a significant difference in DeltaNRS was found 
      between the MC1 group and the group without MC (median DeltaNRS -5.0 vs -2.5, 
      respectively, P = 0.012). CONCLUSIONS: We propose that MC type 1 are associated 
      with lumbar spinal pain, and that the pain arises at least partly from the 
      adjacent IVD or endplate.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Korhonen, Tero
AU  - Korhonen T
AD  - Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, 
      University of Oulu, PO Box 5000, 90014 Oulu, Finland; Medical Research Center 
      Oulu, Oulu University Hospital and University of Oulu, PO Box 8000, 90014 Oulu, 
      Finland. Electronic address: Tero.Korhonen@student.oulu.fi.
FAU - Jarvinen, Jyri
AU  - Jarvinen J
AD  - Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, 
      University of Oulu, PO Box 5000, 90014 Oulu, Finland; Medical Research Center 
      Oulu, Oulu University Hospital and University of Oulu, PO Box 8000, 90014 Oulu, 
      Finland; Department of Diagnostic Radiology, Oulu University Hospital, PO Box 50, 
      90029 OYS, Oulu, Finland.
FAU - Pesala, Juha
AU  - Pesala J
AD  - Department of Orthopaedics and Traumatology, Oulu University Hospital, PO Box 10, 
      90029 OYS, Oulu, Finland.
FAU - Haapea, Marianne
AU  - Haapea M
AD  - Medical Research Center Oulu, Oulu University Hospital and University of Oulu, PO 
      Box 8000, 90014 Oulu, Finland; Department of Diagnostic Radiology, Oulu 
      University Hospital, PO Box 50, 90029 OYS, Oulu, Finland.
FAU - Niinimaki, Jaakko
AU  - Niinimaki J
AD  - Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, 
      University of Oulu, PO Box 5000, 90014 Oulu, Finland; Medical Research Center 
      Oulu, Oulu University Hospital and University of Oulu, PO Box 8000, 90014 Oulu, 
      Finland; Department of Diagnostic Radiology, Oulu University Hospital, PO Box 50, 
      90029 OYS, Oulu, Finland. Electronic address: Jaakko.Niinimaki@oulu.fi.
LA  - eng
PT  - Journal Article
DEP - 20221101
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Humans
MH  - *Low Back Pain/diagnostic imaging/etiology
MH  - Retrospective Studies
MH  - *Intervertebral Disc Degeneration/complications/diagnostic imaging
MH  - *Intervertebral Disc/diagnostic imaging/pathology
MH  - Lumbosacral Region
MH  - Magnetic Resonance Imaging
MH  - Lumbar Vertebrae/diagnostic imaging/pathology
OTO - NOTNLM
OT  - Chronic
OT  - Disc degeneration
OT  - Discoblock
OT  - Discogenic
OT  - Low back pain
OT  - Modic changes
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/11/11 06:00
MHDA- 2022/12/06 06:00
CRDT- 2022/11/10 18:24
PHST- 2022/07/04 00:00 [received]
PHST- 2022/10/25 00:00 [revised]
PHST- 2022/10/27 00:00 [accepted]
PHST- 2022/11/11 06:00 [pubmed]
PHST- 2022/12/06 06:00 [medline]
PHST- 2022/11/10 18:24 [entrez]
AID - S0720-048X(22)00439-9 [pii]
AID - 10.1016/j.ejrad.2022.110589 [doi]
PST - ppublish
SO  - Eur J Radiol. 2022 Dec;157:110589. doi: 10.1016/j.ejrad.2022.110589. Epub 2022 
      Nov 1.