PMID- 36358479
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221126
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 11
IP  - 11
DP  - 2022 Oct 26
TI  - O-Cyclic Phytosphingosine-1-Phosphate Protects against Motor Dysfunctions and 
      Glial Cell Mediated Neuroinflammation in the Parkinson's Disease Mouse Models.
LID - 10.3390/antiox11112107 [doi]
LID - 2107
AB  - O-cyclic phytosphingosine-1-phosphate (cPS1P) is a novel and chemically 
      synthesized sphingosine metabolite derived from phytosphingosine-1-phosphate 
      (S1P). This study was undertaken to unveil the potential neuroprotective effects 
      of cPS1P on two different mouse models of Parkinson's disease (PD). The study 
      used 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and neuron specific 
      enolase promoter human alpha-synuclein (NSE-halphaSyn) Korl transgenic mice. MPTP was 
      injected for five consecutive days and cPS1P was injected for alternate days for 
      six weeks intraperitoneally. We performed behavioral tests and analyzed the 
      immunohistochemistry and immunofluorescence staining in the substantia nigra pars 
      compacta (SNpc) and the striatum. The behavior tests showed a significant 
      reduction in the motor functions in the PD models, which was reversed with the 
      administration of cPS1P. In addition, both PD-models showed reduced expression of 
      the sphingosine-1-phosphate receptor 1 (S1PR1), and alpha-Syn which was restored with 
      cPS1P treatment. In addition, administration of cPS1P restored dopamine-related 
      proteins such as tyrosine hydroxylase (TH), vesicular monoamine transporter 2 
      (VMAT2), and dopamine transporter (DAT). Lastly, neuroinflammatory related 
      markers such as glial fibrillary acidic protein (GFAP), ionized calcium-binding 
      adapter protein-1 (Iba-1), c-Jun N-terminal kinases (JNK), nuclear factor 
      kappa-light-chain-enhancer of activated B cells (NF-kB), tumor necrosis 
      factor-alpha (TNF-alpha), and interleukin 1 beta (IL-1beta) were all reduced after cPS1P 
      administration. The overall findings supported the notion that cPS1P protects 
      against dopamine depletion, neuroinflammation, and PD-associated symptoms.
FAU - Lee, Hyeon Jin
AU  - Lee HJ
AD  - Division of Life Science and Applied Life Science (BK21 FOUR), College of Natural 
      Sciences, Gyeongsang National University, Jinju 52828, Korea.
FAU - Choe, Kyonghwan
AU  - Choe K
AUID- ORCID: 0000-0001-9150-0155
AD  - Division of Life Science and Applied Life Science (BK21 FOUR), College of Natural 
      Sciences, Gyeongsang National University, Jinju 52828, Korea.
AD  - Department of Psychiatry and Neuropsychology, School for Mental Health and 
      Neuroscience (MHeNs), Maastricht University, 6229ER Maastricht, The Netherlands.
FAU - Park, Jun Sung
AU  - Park JS
AD  - Division of Life Science and Applied Life Science (BK21 FOUR), College of Natural 
      Sciences, Gyeongsang National University, Jinju 52828, Korea.
FAU - Khan, Amjad
AU  - Khan A
AUID- ORCID: 0000-0001-6248-167X
AD  - Division of Life Science and Applied Life Science (BK21 FOUR), College of Natural 
      Sciences, Gyeongsang National University, Jinju 52828, Korea.
FAU - Kim, Min Woo
AU  - Kim MW
AD  - Division of Life Science and Applied Life Science (BK21 FOUR), College of Natural 
      Sciences, Gyeongsang National University, Jinju 52828, Korea.
FAU - Park, Tae Ju
AU  - Park TJ
AD  - Haemato-oncology/Systems Medicine Group, Paul O'Gorman Leukaemia Research Centre, 
      Institute of Cancer Sciences, College of Medical, Veterinary & Life Sciences 
      (MVLS), University of Glasgow, Glasgow G12 0ZD, UK.
FAU - Kim, Myeong Ok
AU  - Kim MO
AD  - Division of Life Science and Applied Life Science (BK21 FOUR), College of Natural 
      Sciences, Gyeongsang National University, Jinju 52828, Korea.
AD  - Alz-Dementia Korea Co., Jinju 52828, Korea.
LA  - eng
GR  - 2020M3E5D9080660/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20221026
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC9686509
OTO - NOTNLM
OT  - O-cyclic phytosphingosine-1-phosphate
OT  - Parkinson's disease
OT  - dopaminergic neuron
OT  - glial cell
OT  - motor dysfunction
OT  - neuroinflammation
OT  - neuroprotection
OT  - oxidative stress
OT  - alpha-synuclein
COIS- The authors declare no conflict of interest.
EDAT- 2022/11/12 06:00
MHDA- 2022/11/12 06:01
PMCR- 2022/10/26
CRDT- 2022/11/11 01:05
PHST- 2022/08/23 00:00 [received]
PHST- 2022/10/14 00:00 [revised]
PHST- 2022/10/22 00:00 [accepted]
PHST- 2022/11/11 01:05 [entrez]
PHST- 2022/11/12 06:00 [pubmed]
PHST- 2022/11/12 06:01 [medline]
PHST- 2022/10/26 00:00 [pmc-release]
AID - antiox11112107 [pii]
AID - antioxidants-11-02107 [pii]
AID - 10.3390/antiox11112107 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2022 Oct 26;11(11):2107. doi: 10.3390/antiox11112107.