PMID- 36359012
OWN - NLM
STAT- MEDLINE
DCOM- 20221114
LR  - 20221201
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 12
IP  - 11
DP  - 2022 Nov 9
TI  - The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) 
      and Subpleural Location in a Mexican Mestizo Population.
LID - 10.3390/biom12111662 [doi]
LID - 1662
AB  - Interstitial lung abnormalities (ILA) are defined as the presence of different 
      patterns of increased lung density, including ground glass attenuation and 
      reticular opacities on chest high-resolution computed tomography (HRCT). In this 
      study, we included 90 subjects with ILA and 189 healthy controls (HC) from our 
      Aging Lung Program. We found that subjects with ILA are older, have a significant 
      smoking history, and have worse pulmonary function than HC (p < 0.05). When we 
      evaluated the allele frequencies of the human leukocyte antigen (HLA) system, we 
      found that HLA-DRB1*07 was associated with a higher risk for ILA (p < 0.05, OR = 
      1.95, 95% CI = 1.06-3.57). When we compared subjects with subpleural ILA vs. HC, 
      the association with HLA-DRB1*07 became stronger than the whole ILA group (p < 
      0.05, OR = 2.29, 95% CI = 1.24-4.25). Furthermore, subjects with subpleural ILA 
      and central ILA display differences in allele frequencies with HLA-DRB1*14 (3.33% 
      vs. 13.33%, p < 0.05) and *15 (3.33% vs. 20%, p < 0.05). Our findings indicate 
      that the HLA-DRB1*07 allele contributes to the risk of ILA, especially those of 
      subpleural locations.
FAU - Buendia-Roldan, Ivette
AU  - Buendia-Roldan I
AUID- ORCID: 0000-0002-2825-506X
AD  - Translational Research Laboratory on Aging and Pulmonary Fibrosis, Instituto 
      Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, 
      Mexico.
FAU - Ponce-Gallegos, Marco Antonio
AU  - Ponce-Gallegos MA
AUID- ORCID: 0000-0003-4992-9913
AD  - HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio 
      Villegas, Mexico City 14080, Mexico.
FAU - Lara-Beltran, Daniela
AU  - Lara-Beltran D
AD  - Translational Research Laboratory on Aging and Pulmonary Fibrosis, Instituto 
      Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, 
      Mexico.
FAU - Del Angel-Pablo, Alma D
AU  - Del Angel-Pablo AD
AUID- ORCID: 0000-0003-4464-4396
AD  - HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio 
      Villegas, Mexico City 14080, Mexico.
FAU - Perez-Rubio, Gloria
AU  - Perez-Rubio G
AUID- ORCID: 0000-0002-6876-1012
AD  - HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio 
      Villegas, Mexico City 14080, Mexico.
FAU - Mejia, Mayra
AU  - Mejia M
AD  - Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de 
      Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, Mexico.
FAU - Selman, Moises
AU  - Selman M
AUID- ORCID: 0000-0002-1022-4783
AD  - Translational Research Laboratory on Aging and Pulmonary Fibrosis, Instituto 
      Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, 
      Mexico.
FAU - Falfan-Valencia, Ramces
AU  - Falfan-Valencia R
AUID- ORCID: 0000-0001-6877-8124
AD  - Translational Research Laboratory on Aging and Pulmonary Fibrosis, Instituto 
      Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, 
      Mexico.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221109
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Humans
MH  - HLA-DRB1 Chains/genetics
MH  - Alleles
MH  - Gene Frequency/genetics
MH  - *Lung
MH  - *Tomography, X-Ray Computed/methods
PMC - PMC9687358
OTO - NOTNLM
OT  - HLA DRB1*07
OT  - ILA
OT  - central ILA
OT  - subpleural ILA
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/12 06:00
MHDA- 2022/11/15 06:00
PMCR- 2022/11/09
CRDT- 2022/11/11 01:08
PHST- 2022/10/14 00:00 [received]
PHST- 2022/11/03 00:00 [revised]
PHST- 2022/11/06 00:00 [accepted]
PHST- 2022/11/11 01:08 [entrez]
PHST- 2022/11/12 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/11/09 00:00 [pmc-release]
AID - biom12111662 [pii]
AID - biomolecules-12-01662 [pii]
AID - 10.3390/biom12111662 [doi]
PST - epublish
SO  - Biomolecules. 2022 Nov 9;12(11):1662. doi: 10.3390/biom12111662.