PMID- 36360140 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221117 IS - 2304-8158 (Print) IS - 2304-8158 (Electronic) IS - 2304-8158 (Linking) VI - 11 IP - 21 DP - 2022 Nov 5 TI - Research Progress on the Preparation and Action Mechanism of Natural Deep Eutectic Solvents and Their Application in Food. LID - 10.3390/foods11213528 [doi] LID - 3528 AB - Natural deep eutectic solvent (NADES) is the eutectic mixture which is formed by hydrogen bond donors (HBDs) and hydrogen bond acceptors (HBAs) with a certain molar ratio through hydrogen bonding. NADES is a liquid with low cost, easy preparation, biodegradability, sustainability and environmental friendliness at room temperature. At present, it is widely used in food, medicine and other areas. First, the composition, preparation and properties of NADES are outlined. Second, the potential mechanism of NADES in freezing preservation, the removal of heavy metals from food and the extraction of phenolic compounds, and its application in cryopreservation, food analysis and food component extraction, and as a food taste enhancer and food film, are summarized. Lastly, the potential and challenges of its application in the food field are reviewed. This review could provide a theoretical basis for the wide application of NADES in food processing and production. FAU - Wu, Kairong AU - Wu K AD - College of Food Science, Northeast Agricultural University, Harbin 150030, China. FAU - Ren, Jing AU - Ren J AD - College of Food Science, Northeast Agricultural University, Harbin 150030, China. FAU - Wang, Qian AU - Wang Q AD - College of Food Science, Northeast Agricultural University, Harbin 150030, China. FAU - Nuerjiang, Maheshati AU - Nuerjiang M AD - College of Food Science, Northeast Agricultural University, Harbin 150030, China. FAU - Xia, Xiufang AU - Xia X AD - College of Food Science, Northeast Agricultural University, Harbin 150030, China. FAU - Bian, Chun AU - Bian C AD - School of Food Engineering, Harbin University, Harbin 150036, China. LA - eng GR - 32172273/National Natural Science Foundation of China/ PT - Journal Article PT - Review DEP - 20221105 PL - Switzerland TA - Foods JT - Foods (Basel, Switzerland) JID - 101670569 PMC - PMC9655939 OTO - NOTNLM OT - application OT - green solvent OT - mechanism OT - natural deep eutectic solvent OT - properties COIS- The authors declare no conflict of interest. EDAT- 2022/11/12 06:00 MHDA- 2022/11/12 06:01 PMCR- 2022/11/05 CRDT- 2022/11/11 01:14 PHST- 2022/09/28 00:00 [received] PHST- 2022/10/27 00:00 [revised] PHST- 2022/10/28 00:00 [accepted] PHST- 2022/11/11 01:14 [entrez] PHST- 2022/11/12 06:00 [pubmed] PHST- 2022/11/12 06:01 [medline] PHST- 2022/11/05 00:00 [pmc-release] AID - foods11213528 [pii] AID - foods-11-03528 [pii] AID - 10.3390/foods11213528 [doi] PST - epublish SO - Foods. 2022 Nov 5;11(21):3528. doi: 10.3390/foods11213528.