PMID- 36362805
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 21
DP  - 2022 Nov 6
TI  - Clinical Outcomes and Prevalence of Sarcopenia in Patients with Moderate to 
      Severe COVID-19.
LID - 10.3390/jcm11216578 [doi]
LID - 6578
AB  - Background: The purpose of this study was to investigate the effectiveness and 
      clinical outcomes of inpatient rehabilitation for patients with severe COVID-19 
      in Japan. Methods: Patients with severe COVID-19 who underwent rehabilitation 
      during hospitalization were included. The Medical Research Council (MRC) score 
      and short physical performance battery (SPPB), such as physical function 
      assessment and the intensive care unit (ICU) mobility scale, the functional 
      status score for the ICU, and Barthel index as activities of daily living (ADLs) 
      were evaluated at admission and discharge or transfer from the hospital. The 
      correlation between SPPB at discharge and each factor at admission were also 
      analyzed. Furthermore, the prevalence of sarcopenia was evaluated by defining 
      SPPB of <9 points at discharge as sarcopenia. Results: The median age of the 
      total of 23 patients was 59 years (interquartile range (IQR): 47-67), 73.9% were 
      male, and the median PaO2/FiO2 at admission was 172.0 (IQR: 123.0-209.0). All 
      physical function and ADL parameters were significantly improved from the time of 
      admission to discharge (p = 0.014 for the MRC score and p < 0.001 for all 
      others). Moreover, SPPB at discharge significantly correlated with WBC 
      (Spearman's rho = -0.473, p = 0.041), C-reactive protein (Spearman's rho = 
      -0.468, p = 0.044), and exhibited a significant trend with PaO2/FiO2 (Spearman's 
      rho = 0.429, p = 0.067) and age (Spearman's rho = 0.409, p = 0.083). Although the 
      median Barthel index at discharge was 90 points, 47% of patients had sarcopenia 
      as defined by an SPPB of <9 points. Conclusions: Early rehabilitation for 
      patients with severe COVID-19 improved physical function and ADLs during 
      hospitalization. However, 47% of patients had the same level of sarcopenia at 
      discharge.
FAU - Yamamoto, Shuhei
AU  - Yamamoto S
AUID- ORCID: 0000-0003-0257-633X
AD  - Department of Rehabilitation, Shinshu University Hospital, Nagano 390-8621, 
      Japan.
FAU - Sakai, Yasunari
AU  - Sakai Y
AD  - Department of Rehabilitation, Shinshu University Hospital, Nagano 390-8621, 
      Japan.
FAU - Matsumori, Keiji
AU  - Matsumori K
AD  - Department of Rehabilitation, Shinshu University Hospital, Nagano 390-8621, 
      Japan.
FAU - Osawa, Ryuji
AU  - Osawa R
AD  - Department of Rehabilitation, Shinshu University Hospital, Nagano 390-8621, 
      Japan.
FAU - Ito, Shun
AU  - Ito S
AD  - Department of Rehabilitation, Shinshu University Hospital, Nagano 390-8621, 
      Japan.
FAU - Tsukakoshi, Daichi
AU  - Tsukakoshi D
AUID- ORCID: 0000-0003-0771-325X
AD  - Department of Rehabilitation, Shinshu University Hospital, Nagano 390-8621, 
      Japan.
FAU - Ohno, Tomoki
AU  - Ohno T
AD  - Department of Rehabilitation, Shinshu University Hospital, Nagano 390-8621, 
      Japan.
FAU - Ohta, Hiroaki
AU  - Ohta H
AD  - Department of Rehabilitation, Shinshu University Hospital, Nagano 390-8621, 
      Japan.
FAU - Ichiyama, Takashi
AU  - Ichiyama T
AUID- ORCID: 0000-0002-1962-6738
AD  - Department of Intensive Care Unit, Shinshu University Hospital, Nagano 390-8621, 
      Japan.
FAU - Komatsu, Masamichi
AU  - Komatsu M
AUID- ORCID: 0000-0002-1228-1490
AD  - First Department of Internal Medicine, Shinshu University School of Medicine, 
      Nagano 390-8621, Japan.
FAU - Wada, Yosuke
AU  - Wada Y
AUID- ORCID: 0000-0003-3349-2980
AD  - First Department of Internal Medicine, Shinshu University School of Medicine, 
      Nagano 390-8621, Japan.
FAU - Hanaoka, Masayuki
AU  - Hanaoka M
AD  - First Department of Internal Medicine, Shinshu University School of Medicine, 
      Nagano 390-8621, Japan.
FAU - Ikegami, Shota
AU  - Ikegami S
AD  - Department of Rehabilitation, Shinshu University Hospital, Nagano 390-8621, 
      Japan.
FAU - Horiuchi, Hiroshi
AU  - Horiuchi H
AD  - Department of Rehabilitation, Shinshu University Hospital, Nagano 390-8621, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20221106
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9654044
OTO - NOTNLM
OT  - COVID-19
OT  - activities of daily living
OT  - rehabilitation
OT  - sarcopenia
COIS- The authors declare no conflict of interest.
EDAT- 2022/11/12 06:00
MHDA- 2022/11/12 06:01
PMCR- 2022/11/06
CRDT- 2022/11/11 01:32
PHST- 2022/08/13 00:00 [received]
PHST- 2022/10/16 00:00 [revised]
PHST- 2022/11/03 00:00 [accepted]
PHST- 2022/11/11 01:32 [entrez]
PHST- 2022/11/12 06:00 [pubmed]
PHST- 2022/11/12 06:01 [medline]
PHST- 2022/11/06 00:00 [pmc-release]
AID - jcm11216578 [pii]
AID - jcm-11-06578 [pii]
AID - 10.3390/jcm11216578 [doi]
PST - epublish
SO  - J Clin Med. 2022 Nov 6;11(21):6578. doi: 10.3390/jcm11216578.