PMID- 36362901
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221129
IS  - 2075-1729 (Print)
IS  - 2075-1729 (Electronic)
IS  - 2075-1729 (Linking)
VI  - 12
IP  - 11
DP  - 2022 Oct 31
TI  - Sex-Related Differences in Short-Term Outcomes after Mobile VA-ECMO Implantation: 
      Five-Year Experience of an ECMO Retrieval Program.
LID - 10.3390/life12111746 [doi]
LID - 1746
AB  - Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) represents an 
      increasingly used method for circulatory support. Despite the ongoing research, 
      survival following VA-ECMO therapy remains low. Sex-related differences might 
      impact the outcome of therapeutic measures. We aimed to compare all-cause 
      mortality among female and male patients who underwent VA-ECMO as a bridge to 
      recovery investigating sex-related differences. From January 2015 until August 
      2020, 87 patients were supported by VA-ECMO as a part of our out-of-center mobile 
      ECMO program. In order to analyze sex-associated differences in early clinical 
      outcomes, patients were divided into two sex categories: men (n = 62) and women 
      (n = 25). All relevant data (in-hospital mortality, ICU and hospital stay, renal 
      failure requiring dialysis, lung failure, bleeding, stroke and septic shock) were 
      analyzed retrospectively after the extraction from our institutional database. 
      Mean age of the study population was 53 +/- 14 years. Mean EuroSCORE II predicted 
      mortality was 6.5 +/- 3.7. In-hospital mortality rate was not significantly lower 
      in the female group (58.3%) vs. the male group (71.2%), p = 0.190. The mean 
      length of ICU and hospital stay was 9 +/- 11 in the male group vs. 10 +/- 13 in the 
      female group, p = 0.901, and 10 +/- 12 (male group) vs. 11 +/- 13 (female group), p = 
      0.909, respectively. Renal failure requiring hemodialysis (36.2% (males) vs. 
      28.6% (females), p = 0.187) was comparable between both groups. Respiratory 
      failure was diagnosed in 31 (56.4%) male vs. 8 (34.8%) female patients, p = 
      0.068, while 16 (28.6%) male vs. 3 (13.0%) female patients (p = 0.118) suffered 
      from septic shock. Based on our data, there were no sex-specific outcome 
      discrepancies in patients treated with mobile VA-ECMO implantation.
FAU - Krasivskyi, Ihor
AU  - Krasivskyi I
AUID- ORCID: 0000-0003-0573-8218
AD  - Department of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, 
      Germany.
FAU - Ivanov, Borko
AU  - Ivanov B
AD  - Department of Cardiothoracic Surgery, Helios Hospital Siegburg, 53721 Siegburg, 
      Germany.
FAU - Vehrenberg, Johannes
AU  - Vehrenberg J
AD  - Department of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, 
      Germany.
FAU - Eghbalzadeh, Kaveh
AU  - Eghbalzadeh K
AUID- ORCID: 0000-0001-6941-7785
AD  - Department of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, 
      Germany.
FAU - Gerfer, Stephen
AU  - Gerfer S
AD  - Department of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, 
      Germany.
FAU - Gaisendrees, Christopher
AU  - Gaisendrees C
AD  - Department of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, 
      Germany.
FAU - Kuhn, Elmar
AU  - Kuhn E
AD  - Department of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, 
      Germany.
FAU - Sabashnikov, Anton
AU  - Sabashnikov A
AD  - Department of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, 
      Germany.
FAU - Mader, Navid
AU  - Mader N
AD  - Department of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, 
      Germany.
FAU - Djordjevic, Ilija
AU  - Djordjevic I
AUID- ORCID: 0000-0002-5810-8626
AD  - Department of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, 
      Germany.
FAU - Wahlers, Thorsten
AU  - Wahlers T
AD  - Department of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20221031
PL  - Switzerland
TA  - Life (Basel)
JT  - Life (Basel, Switzerland)
JID - 101580444
PMC - PMC9695761
OTO - NOTNLM
OT  - VA-ECMO
OT  - cardiogenic shock
OT  - sex
COIS- The authors declare no conflict of interest.
EDAT- 2022/11/12 06:00
MHDA- 2022/11/12 06:01
PMCR- 2022/10/31
CRDT- 2022/11/11 01:33
PHST- 2022/10/18 00:00 [received]
PHST- 2022/10/20 00:00 [revised]
PHST- 2022/10/21 00:00 [accepted]
PHST- 2022/11/11 01:33 [entrez]
PHST- 2022/11/12 06:00 [pubmed]
PHST- 2022/11/12 06:01 [medline]
PHST- 2022/10/31 00:00 [pmc-release]
AID - life12111746 [pii]
AID - life-12-01746 [pii]
AID - 10.3390/life12111746 [doi]
PST - epublish
SO  - Life (Basel). 2022 Oct 31;12(11):1746. doi: 10.3390/life12111746.