PMID- 36362989
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221129
IS  - 2075-1729 (Print)
IS  - 2075-1729 (Electronic)
IS  - 2075-1729 (Linking)
VI  - 12
IP  - 11
DP  - 2022 Nov 9
TI  - The Multiple Roles of Pericytes in Vascular Formation and Microglial Functions in 
      the Brain.
LID - 10.3390/life12111835 [doi]
LID - 1835
AB  - In the capillary walls, vascular endothelial cells are covered with mural cells, 
      such as smooth muscle cells and pericytes. Although pericytes had been thought to 
      play simply a structural role, emerging evidence has highlighted their multiple 
      functions in the embryonic, postnatal, and adult brain. As the central nervous 
      system (CNS) develops, the brain's vascular structure gradually matures into a 
      hierarchical network, which is crucial for the proper development of neural 
      lineage cells by providing oxygen and nutrients. Pericytes play an essential role 
      in vascular formation and regulate blood‒brain barrier (BBB) integrity as a 
      component of the neurovascular unit (NVU), in collaboration with other cells, 
      such as vascular endothelial cells, astrocytes, neurons, and microglia. 
      Microglia, the resident immune cells of the CNS, colonize the brain at embryonic 
      day (E) 9.5 in mice. These cells not only support the development and maturation 
      of neural lineage cells but also help in vascular formation through their 
      extensive migration. Recent studies have demonstrated that pericytes directly 
      contact microglia in the CNS, and their interactions have a profound effect on 
      physiological and pathological aspects. This review summarizes the function of 
      pericytes, focusing on the interplay between pericytes and microglia.
FAU - Hattori, Yuki
AU  - Hattori Y
AUID- ORCID: 0000-0001-6576-0121
AD  - Department of Anatomy and Cell Biology, Nagoya University Graduate School of 
      Medicine, Nagoya 466-8550, Japan.
LA  - eng
GR  - JP21K15330/Japan Society for the Promotion of Science/
GR  - JP21H05624/Japan Society for the Promotion of Science/
PT  - Journal Article
PT  - Review
DEP - 20221109
PL  - Switzerland
TA  - Life (Basel)
JT  - Life (Basel, Switzerland)
JID - 101580444
PMC - PMC9699346
OTO - NOTNLM
OT  - blood vessel
OT  - blood-brain barrier
OT  - brain development
OT  - cortex
OT  - endothelial cell
OT  - microglia
OT  - neurovascular unit
OT  - pericyte
OT  - vascular structure
COIS- The author declares no conflict of interest.
EDAT- 2022/11/12 06:00
MHDA- 2022/11/12 06:01
PMCR- 2022/11/09
CRDT- 2022/11/11 01:33
PHST- 2022/10/24 00:00 [received]
PHST- 2022/11/07 00:00 [revised]
PHST- 2022/11/08 00:00 [accepted]
PHST- 2022/11/11 01:33 [entrez]
PHST- 2022/11/12 06:00 [pubmed]
PHST- 2022/11/12 06:01 [medline]
PHST- 2022/11/09 00:00 [pmc-release]
AID - life12111835 [pii]
AID - life-12-01835 [pii]
AID - 10.3390/life12111835 [doi]
PST - epublish
SO  - Life (Basel). 2022 Nov 9;12(11):1835. doi: 10.3390/life12111835.