PMID- 36363477
OWN - NLM
STAT- MEDLINE
DCOM- 20221114
LR  - 20230308
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 58
IP  - 11
DP  - 2022 Oct 25
TI  - Perioperative Red Cell Line Trend following Robot-Assisted Radical Prostatectomy 
      for Prostate Cancer.
LID - 10.3390/medicina58111520 [doi]
LID - 1520
AB  - Background and Objective: Blood loss represents a long-standing concern of 
      radical prostatectomy (RP). This study aimed to assess how red line cell values 
      changed following robot-assisted radical prostatectomy (RARP) for prostate cancer 
      (PCa). Materials and Methods: The blood panels of 453 consecutive PCa patients 
      undergoing RARP at a single tertiary academic referral center, from September 
      2020 to April 2022, were reviewed. Data from 363 patients with the blood panel 
      available for the following timeframe: within seven days before surgery, six 
      hours after surgery, and the first three postoperative days, were analyzed. 
      Specifically, hemoglobin (Hb, g/dL), red blood cells (RBCs, x106/muL), and 
      hematocrit (HCT, %) trends were collected. Results: Considering the Hb trend, the 
      median values in the preoperative day, postoperative day (POD) 2, and POD 3 are 
      14.7 (interquartile range (IQR) = 13.9-15.4), 12.1 (IQR = 11.2-12.9), and 12.2 
      (IQR = 11.2-13.1), respectively. The ∆ between preoperative day and POD 2 is 2.5 
      (IQR = 1.8-3.2) (p < 0.001). Considering the RBCs trend, the median values in the 
      preoperative day, POD 2, and POD 3 are 4.9 (IQR = 4.7-5.3), 4.1 (IQR = 3.8-4.4), 
      and 4.1 (IQR = 3.8-4.5), respectively. The ∆ between preoperative day and POD 2 
      is 0.9 (IQR = 0.6-1.1) (p < 0.001). Considering the HCT trend, the median values 
      in the preoperative day, POD 2, and POD 3 are 44.4 (IQR = 41.7-46.6), 36.4 (IQR = 
      33.8-38.9), and 36.1 (IQR = 33.5-38.7), respectively. The ∆ between preoperative 
      day and POD 2 is 7.8 (IQR = 5.2-10.5) (p < 0.001). Conclusions: Overall, patients 
      undergoing RARP experience a significant, but clinically limited, decline in red 
      line cell values between the preoperative time and the second day post-surgery. 
      These observations are important to provide physicians with knowledge of the 
      expected postoperative course and, thus, to improve the quality of patient care.
FAU - Di Bello, Francesco
AU  - Di Bello F
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - Di Mauro, Ernesto
AU  - Di Mauro E
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - Colla Ruvolo, Claudia
AU  - Colla Ruvolo C
AUID- ORCID: 0000-0001-8110-7341
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - Creta, Massimiliano
AU  - Creta M
AUID- ORCID: 0000-0003-2082-3330
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - La Rocca, Roberto
AU  - La Rocca R
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - Celentano, Giuseppe
AU  - Celentano G
AUID- ORCID: 0000-0002-3346-8385
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - Capece, Marco
AU  - Capece M
AUID- ORCID: 0000-0002-1951-404X
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - Napolitano, Luigi
AU  - Napolitano L
AUID- ORCID: 0000-0003-2036-0356
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - Morra, Simone
AU  - Morra S
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - Pezone, Gabriele
AU  - Pezone G
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - Passaro, Francesco
AU  - Passaro F
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - De Luca, Ciro
AU  - De Luca C
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - Mangiapia, Francesco
AU  - Mangiapia F
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - Logrieco, Nicola
AU  - Logrieco N
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - Buonanno, Pasquale
AU  - Buonanno P
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - Servillo, Giuseppe
AU  - Servillo G
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - Imbimbo, Ciro
AU  - Imbimbo C
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - Mirone, Vincenzo
AU  - Mirone V
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - Longo, Nicola
AU  - Longo N
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
FAU - Califano, Gianluigi
AU  - Califano G
AD  - Department of Neuroscience, Reproductive and Odontostomatological Sciences, 
      University of Naples "Federico II", Via Pansini, 80138 Naples, Italy.
LA  - eng
PT  - Journal Article
DEP - 20221025
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
SB  - IM
MH  - Male
MH  - Humans
MH  - *Robotics
MH  - *Robotic Surgical Procedures
MH  - Treatment Outcome
MH  - Prostatectomy
MH  - *Prostatic Neoplasms/surgery
MH  - Erythrocytes
MH  - Cell Line
PMC - PMC9695953
OTO - NOTNLM
OT  - PCa
OT  - RARP
OT  - blood loss
OT  - hematocrit
OT  - hemoglobin
OT  - red blood cell
OT  - surgery
OT  - surgical oncology
COIS- The authors declare no conflict of interest.
EDAT- 2022/11/12 06:00
MHDA- 2022/11/15 06:00
PMCR- 2022/10/25
CRDT- 2022/11/11 01:36
PHST- 2022/09/29 00:00 [received]
PHST- 2022/10/22 00:00 [revised]
PHST- 2022/10/22 00:00 [accepted]
PHST- 2022/11/11 01:36 [entrez]
PHST- 2022/11/12 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/10/25 00:00 [pmc-release]
AID - medicina58111520 [pii]
AID - medicina-58-01520 [pii]
AID - 10.3390/medicina58111520 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2022 Oct 25;58(11):1520. doi: 10.3390/medicina58111520.