PMID- 36364794
OWN - NLM
STAT- MEDLINE
DCOM- 20221118
LR  - 20221118
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 21
DP  - 2022 Oct 28
TI  - The Acute Effects of Milk Consumption on Systemic Inflammation after Combined 
      Resistance and Plyometric Exercise in Young Adult Females.
LID - 10.3390/nu14214532 [doi]
LID - 4532
AB  - High-intensity/impact exercise elicits a transient increase in inflammatory 
      biomarkers. Consuming nutrient-dense wholefoods, like milk, following exercise 
      may modulate post-exercise inflammation and aid recovery. We examined the effect 
      of post-exercise skim milk consumption (versus an isoenergetic, isovolumetric 
      carbohydrate [CHO] drink) on acute exercise-induced inflammation in untrained 
      females. Using a randomized crossover design, 13 healthy females (age = 20 +/- 2.3 
      y; BMI = 21.0 +/- 1.1 kg/m(2)) completed two bouts of combined 
      resistance/plyometric exercise followed by either skim milk (MILK) or CHO at 
      5-min and 1 h post-exercise. Serum interleukin [IL]-1beta, IL-6, IL-10, and tumor 
      necrosis factor-alpha (TNF-alpha) concentrations were measured at pre-exercise, 
      15-min, 75-min, 24 h, and 48 h post-exercise. IL-6 increased 15-min post-exercise 
      vs. all other timepoints (time effect, p = 0.017). Between 24 and 48 h, IL-10 
      decreased and increased in the MILK and CHO conditions, respectively 
      (interaction, p = 0.018). There were no significant effects for IL-1beta or TNF-alpha. 
      Relative concentrations of IL-1beta (p = 0.049) and IL-10 (p = 0.028) at 48 h 
      post-exercise were lower in MILK vs. CHO. Milk post-exercise did not influence 
      the absolute concentration of pro-inflammatory cytokines; however, there were 
      divergent responses for the anti-inflammatory cytokine, IL-10, and milk reduced 
      the relative inflammatory response at 48 h (vs. CHO) for IL-1beta and IL-10. This 
      demonstrates the potential for milk to modulate inflammation post-exercise in 
      this sample.
FAU - Fraschetti, Emily C
AU  - Fraschetti EC
AD  - School of Kinesiology and Health Science, Faculty of Health, York University, 
      Toronto, ON M3J 1P3, Canada.
FAU - Skelly, Lauren E
AU  - Skelly LE
AD  - School of Kinesiology and Health Science, Faculty of Health, York University, 
      Toronto, ON M3J 1P3, Canada.
FAU - Prowting, Joel L
AU  - Prowting JL
AD  - School of Kinesiology and Health Science, Faculty of Health, York University, 
      Toronto, ON M3J 1P3, Canada.
FAU - Abdul-Sater, Ali A
AU  - Abdul-Sater AA
AD  - School of Kinesiology and Health Science, Faculty of Health, York University, 
      Toronto, ON M3J 1P3, Canada.
FAU - Josse, Andrea R
AU  - Josse AR
AUID- ORCID: 0000-0002-7247-9466
AD  - School of Kinesiology and Health Science, Faculty of Health, York University, 
      Toronto, ON M3J 1P3, Canada.
AD  - Department of Kinesiology, Faculty of Applied Health Sciences, Brock University, 
      St. Catharines, ON L2S 3A1, Canada.
LA  - eng
GR  - NA/York University/
GR  - NA/Brock University/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20221028
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Cytokines)
RN  - 130068-27-8 (Interleukin-10)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Humans
MH  - Young Adult
MH  - Cytokines
MH  - Inflammation
MH  - *Interleukin-10
MH  - Interleukin-6
MH  - *Plyometric Exercise
MH  - Tumor Necrosis Factor-alpha
MH  - Cross-Over Studies
PMC - PMC9653881
OTO - NOTNLM
OT  - acute exercise
OT  - dairy products
OT  - exercise-induced muscle damage
OT  - inflammation
COIS- Authors report no conflict of interest for the present work. A.R.J. reports grant 
      funding and consulting fees from Dairy Farmers of Canada and grant funding from 
      Dairy Management Inc. for projects outside the present work. A.R.J. reports 
      non-financial support from Danone and Lactalis outside the present work. L.E.S. 
      reports grant funding from Dairy Farmers of Canada and salary support from Dairy 
      Management Inc. outside the present work. The funders had no role in the design, 
      execution, interpretation, or writing of the study.
EDAT- 2022/11/12 06:00
MHDA- 2022/11/15 06:00
PMCR- 2022/10/28
CRDT- 2022/11/11 01:45
PHST- 2022/09/30 00:00 [received]
PHST- 2022/10/24 00:00 [revised]
PHST- 2022/10/26 00:00 [accepted]
PHST- 2022/11/11 01:45 [entrez]
PHST- 2022/11/12 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/10/28 00:00 [pmc-release]
AID - nu14214532 [pii]
AID - nutrients-14-04532 [pii]
AID - 10.3390/nu14214532 [doi]
PST - epublish
SO  - Nutrients. 2022 Oct 28;14(21):4532. doi: 10.3390/nu14214532.