PMID- 36364821
OWN - NLM
STAT- MEDLINE
DCOM- 20221114
LR  - 20230308
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 21
DP  - 2022 Oct 29
TI  - Inverse Association of Fruit and Vegetable Consumption with Nonalcoholic Fatty 
      Liver Disease in Chinese Patients with Type 2 Diabetes Mellitus.
LID - 10.3390/nu14214559 [doi]
LID - 4559
AB  - We aimed to investigate the association of fruit and vegetable consumption with 
      nonalcoholic fatty liver disease (NAFLD) in Chinese patients with type 2 diabetes 
      mellitus (T2DM). This cross-sectional study included 2667 Chinese patients with 
      T2DM aged 18 to 76 years from March 2017 to October 2021. Dietary intake was 
      assessed using a food frequency questionnaire, and prevalent NAFLD was diagnosed 
      with abdominal ultrasonography. High fruit-vegetable consumption was determined 
      using >/=500 g/day consumption of both fruit and vegetable, and both fruit and 
      vegetable consumption were divided into three categories of <200 g/day (low), 
      200-400 g/day (median) and >400 g (high). The primary outcome measurement was 
      multivariate-adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for 
      the prevalence of NAFLD in relation to the highest fruit and (or) vegetable 
      intake compared with the lowest. Secondary analyses were conducted to assess the 
      effects of either fruit or vegetable intake on the fatty liver index (FLI) using 
      multivariable linear regressions. There were 1694 men and 973 women in this 
      study, and 1445 (54.06%) participants had prevalent NAFLD. Patients with high 
      fruit-vegetable intake had a lower prevalence of NAFLD than those with low 
      fruit-vegetable intake (52.04% vs. 56.48%), but this difference was not 
      statistically significant (p = 0.065). Vegetable intake had a significantly 
      inverse association with NAFLD (OR: 0.68, 95% CI: 0.52-0.90), but this 
      association was not pronounced with fruit intake (OR: 1.23, 95% CI: 0.89-1.69) or 
      fruit-vegetable intake (OR: 0.90, 95% CI: 0.73-1.10). Additional analyses showed 
      that an increase in vegetable intake was linearly associated with a significant 
      reduction in FLI (beta: -1.028, 95% CI: -1.836, -0.219). In conclusion, higher 
      vegetable consumption was associated with lower odds of NAFLD in Chinese patients 
      with T2DM, which suggested that increased vegetable intake might protect patients 
      with diabetes against NAFLD.
FAU - Du, Lin-Jia
AU  - Du LJ
AUID- ORCID: 0000-0002-1950-5469
AD  - Department of Endocrine and Metabolic Diseases, 1st Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou 325000, China.
FAU - He, Zhi-Ying
AU  - He ZY
AD  - Department of Endocrine and Metabolic Diseases, 1st Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou 325000, China.
FAU - Gu, Xiao
AU  - Gu X
AD  - Department of Endocrine and Metabolic Diseases, 1st Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou 325000, China.
FAU - Hu, Xiang
AU  - Hu X
AD  - Department of Endocrine and Metabolic Diseases, 1st Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou 325000, China.
FAU - Zhang, Xing-Xing
AU  - Zhang XX
AD  - Department of Endocrine and Metabolic Diseases, 1st Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou 325000, China.
FAU - Yang, Li-Juan
AU  - Yang LJ
AD  - Department of Endocrine and Metabolic Diseases, 1st Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou 325000, China.
FAU - Li, Jing
AU  - Li J
AD  - Department of Endocrine and Metabolic Diseases, 1st Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou 325000, China.
FAU - Pan, Lin-Yu
AU  - Pan LY
AD  - Department of Endocrine and Metabolic Diseases, 1st Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou 325000, China.
FAU - Li, Ying-Qian
AU  - Li YQ
AD  - Department of Endocrine and Metabolic Diseases, 1st Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou 325000, China.
FAU - Yang, Bo
AU  - Yang B
AUID- ORCID: 0000-0003-4475-2426
AD  - School of Public Health and Management, Wenzhou Medical University, Chashan 
      University Town, Wenzhou 325015, China.
FAU - Gu, Xue-Jiang
AU  - Gu XJ
AD  - Department of Endocrine and Metabolic Diseases, 1st Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou 325000, China.
LA  - eng
GR  - 2021C03069/Key Research and Development Program of Zhejiang/
GR  - LY20H070003/Natural Science Foundation of Zhejiang Province/
GR  - 81900737/National Natural Science Foundation of China/
GR  - KYYW202015/Basic Scientific Research Program of Wenzhou Medical University, 
      China/
PT  - Journal Article
DEP - 20221029
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - Vegetables
MH  - Fruit
MH  - *Non-alcoholic Fatty Liver Disease/epidemiology
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - Cross-Sectional Studies
MH  - Risk Factors
MH  - China/epidemiology
PMC - PMC9657780
OTO - NOTNLM
OT  - NAFLD
OT  - dietary
OT  - fruit and vegetable
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2022/11/12 06:00
MHDA- 2022/11/15 06:00
PMCR- 2022/10/29
CRDT- 2022/11/11 01:45
PHST- 2022/09/13 00:00 [received]
PHST- 2022/10/14 00:00 [revised]
PHST- 2022/10/17 00:00 [accepted]
PHST- 2022/11/11 01:45 [entrez]
PHST- 2022/11/12 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/10/29 00:00 [pmc-release]
AID - nu14214559 [pii]
AID - nutrients-14-04559 [pii]
AID - 10.3390/nu14214559 [doi]
PST - epublish
SO  - Nutrients. 2022 Oct 29;14(21):4559. doi: 10.3390/nu14214559.