PMID- 36364825
OWN - NLM
STAT- MEDLINE
DCOM- 20221114
LR  - 20230308
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 21
DP  - 2022 Oct 30
TI  - Live and Heat-Killed Probiotic Lactobacillus paracasei PS23 Accelerated the 
      Improvement and Recovery of Strength and Damage Biomarkers after Exercise-Induced 
      Muscle Damage.
LID - 10.3390/nu14214563 [doi]
LID - 4563
AB  - Excessive, high-intensity or inappropriate exercise may cause muscle damage. How 
      to speed up recovery and reduce exercise discomfort are currently very important 
      issues for athletes and sports people. Past research has shown that probiotics 
      can improve inflammation and oxidative stress, as well as improve exercise 
      performance and antifatigue. However, further research is needed to confirm the 
      recovery benefits for muscle damage. In this double-blind design study, all 
      subjects were randomly assigned to placebo, a live Lactobacillus paracasei group 
      (L-PS23, 2 x 1010 colony forming unit (CFU)/day), or a heat-killed L. paracasei 
      group (HK-PS23, 2 x 1010 cells/day), and supplemented for six consecutive weeks. 
      Afterwards, subjects completed 100 maximal vertical jumps to bring about 
      exercise-induced muscle damage (EIMD). Countermovement jump (CMJ), isometric 
      mid-thigh pull (IMTP), and Wingate anaerobic test (WAnT), as well as blood tests 
      for markers of muscle damage and inflammation were made pre-exercise and 3, 24, 
      48 h post exercise. The results show that both L-PS23 and HK-PS23 supplementation 
      significantly slowed the loss of muscle strength after muscle injury, and they 
      significantly reduced the production of markers of muscle damage and inflammation 
      (p < 0.05). In addition, L-PS23 and HK-PS23 had the benefits of accelerating the 
      recovery and improvement of muscle strength, the blood markers of muscle injury 
      and inflammation, and slowing the decline in testosterone concentrations (p < 
      0.05). Especially in the HK-PS23 supplemented group, there was a better trend. In 
      conclusion, we found that L-PS23 or HK-PS23 supplementation for six weeks 
      prevented strength loss after muscle damage and improved blood muscle damage and 
      inflammatory markers, with protective, accelerated recovery and anti-fatigue 
      benefits.
FAU - Lee, Mon-Chien
AU  - Lee MC
AD  - Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 
      City 333325, Taiwan.
FAU - Ho, Chin-Shan
AU  - Ho CS
AD  - Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 
      City 333325, Taiwan.
FAU - Hsu, Yi-Ju
AU  - Hsu YJ
AD  - Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 
      City 333325, Taiwan.
FAU - Huang, Chi-Chang
AU  - Huang CC
AUID- ORCID: 0000-0003-1446-6787
AD  - Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 
      City 333325, Taiwan.
LA  - eng
GR  - NTSU No.1111040/Bened Biomedical Co. Ltd./
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20221030
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - *Lacticaseibacillus paracasei/physiology
MH  - Hot Temperature
MH  - *Probiotics
MH  - Muscle Strength
MH  - Biomarkers
MH  - Inflammation
MH  - Muscles
MH  - Muscle, Skeletal/physiology
MH  - Double-Blind Method
PMC - PMC9658587
OTO - NOTNLM
OT  - Lactobacillus paracasei PS23
OT  - exercise
OT  - heat-killed bacteria
OT  - muscle damage
OT  - probiotic
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2022/11/12 06:00
MHDA- 2022/11/15 06:00
PMCR- 2022/10/30
CRDT- 2022/11/11 01:45
PHST- 2022/10/07 00:00 [received]
PHST- 2022/10/26 00:00 [revised]
PHST- 2022/10/27 00:00 [accepted]
PHST- 2022/11/11 01:45 [entrez]
PHST- 2022/11/12 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/10/30 00:00 [pmc-release]
AID - nu14214563 [pii]
AID - nutrients-14-04563 [pii]
AID - 10.3390/nu14214563 [doi]
PST - epublish
SO  - Nutrients. 2022 Oct 30;14(21):4563. doi: 10.3390/nu14214563.