PMID- 36367513
OWN - NLM
STAT- MEDLINE
DCOM- 20230404
LR  - 20230404
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 316
IP  - Pt 1
DP  - 2023 Jan 1
TI  - Fetal exposure to organic contaminants revealed by infant hair: A preliminary 
      study in south China.
PG  - 120536
LID - S0269-7491(22)01750-X [pii]
LID - 10.1016/j.envpol.2022.120536 [doi]
AB  - Fetal exposure to multiple organic contaminants (OCs) is a public concern because 
      of the adverse effects of OCs on early life development. Infant hair has the 
      potential to be used as an alternative matrix to identify susceptible fetuses, 
      owing to its reliability, sensitivity, and advantages associated with sampling, 
      handling, and ethics. However, the applicability of infant hair for assessing in 
      utero exposure to OCs is still limited. In this study, 57 infant hair samples 
      were collected in Guangzhou, South China, to evaluate the levels and compositions 
      of typical OCs in the fetus. Most of the target OCs were detected in infant hair, 
      with medians of 144 mug/g, 17.7 mug/g, 192 ng/g, 46.9 ng/g, and 1.36 ng/g for 
      phthalate esters (PAEs), alternative plasticizers (APs), organophosphorus flame 
      retardants (OPFRs), polybrominated diphenyl ethers (PBDEs), and organochlorine 
      pesticides (OCPs), respectively. Meanwhile, paired maternal hair (0-9 cm from the 
      scalp) was collected to examine the associations between maternal and infant hair 
      for individual compounds. Low-brominated PBDEs tended to deposit in infant hair, 
      with median concentrations approximately two times higher than those in maternal 
      samples. Levels of PBDEs and 4,4'-dichlorodiphenyldichloroethylene (p,p'-DDE) in 
      paired maternal and infant hair showed strong positive correlations (p < 0.05), 
      while most plasticizers (PAEs and APs) were poorly correlated between paired hair 
      samples. Exposure sources were responsible for the variation in correlation 
      between OC levels in the paired infant and maternal samples. Crude relationships 
      between fetal exposure to OCs and birth size were examined using the Bayesian 
      kernel machine regression (BKMR) model. BDE-28 was found to be adversely 
      associated with the birth size. This study provides referential information for 
      evaluating in utero exposure to OCs and their health risks based on infant hair.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Cai, Feng-Shan
AU  - Cai FS
AD  - State Key Laboratory of Organic Geochemistry, Guangdong Provincial Key Laboratory 
      of Environmental Protection and Resources Utilization, Guangzhou Institute of 
      Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, PR China; State 
      Environmental Protection Key Laboratory of Environmental Pollution Health Risk 
      Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou, 510655, PR China; University of Chinese 
      Academy of Sciences, Beijing, 100049, PR China.
FAU - Tang, Bin
AU  - Tang B
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou, 510655, PR China.
FAU - Zheng, Jing
AU  - Zheng J
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou, 510655, PR China; School of Public Health, 
      Key Laboratory of Environmental Pollution and Disease Monitoring of Ministry of 
      Education, Guizhou Medical University, Guiyang, 550000, PR China. Electronic 
      address: zhengjing@scies.org.
FAU - Yan, Xiao
AU  - Yan X
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou, 510655, PR China; School of Public Health, 
      Key Laboratory of Environmental Pollution and Disease Monitoring of Ministry of 
      Education, Guizhou Medical University, Guiyang, 550000, PR China.
FAU - Luo, Wei-Keng
AU  - Luo WK
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou, 510655, PR China.
FAU - He, Mian
AU  - He M
AD  - Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh 
      Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, PR China.
FAU - Luo, Xiao-Jun
AU  - Luo XJ
AD  - State Key Laboratory of Organic Geochemistry, Guangdong Provincial Key Laboratory 
      of Environmental Protection and Resources Utilization, Guangzhou Institute of 
      Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, PR China; 
      Guangdong-Hong Kong-Macao Joint Laboratory for Environmental Pollution and 
      Control, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, 
      Guangzhou, 510640, PR China.
FAU - Ren, Ming-Zhong
AU  - Ren MZ
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou, 510655, PR China.
FAU - Yu, Yun-Jiang
AU  - Yu YJ
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou, 510655, PR China.
FAU - Mai, Bi-Xian
AU  - Mai BX
AD  - State Key Laboratory of Organic Geochemistry, Guangdong Provincial Key Laboratory 
      of Environmental Protection and Resources Utilization, Guangzhou Institute of 
      Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, PR China; 
      Guangdong-Hong Kong-Macao Joint Laboratory for Environmental Pollution and 
      Control, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, 
      Guangzhou, 510640, PR China.
LA  - eng
PT  - Journal Article
DEP - 20221029
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Flame Retardants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 6O7F7IX66E (phthalic acid)
RN  - 0 (Plasticizers)
SB  - IM
MH  - Female
MH  - Humans
MH  - Infant
MH  - Bayes Theorem
MH  - China
MH  - *Flame Retardants/analysis
MH  - Hair/chemistry
MH  - *Halogenated Diphenyl Ethers/analysis
MH  - Maternal Exposure
MH  - Plasticizers
MH  - Reproducibility of Results
OTO - NOTNLM
OT  - Birth size
OT  - Fetal exposure
OT  - Infant hair
OT  - Maternal hair
OT  - Organic contaminants
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/11/12 06:00
MHDA- 2023/02/25 06:00
CRDT- 2022/11/11 10:58
PHST- 2022/04/27 00:00 [received]
PHST- 2022/10/16 00:00 [revised]
PHST- 2022/10/26 00:00 [accepted]
PHST- 2022/11/12 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2022/11/11 10:58 [entrez]
AID - S0269-7491(22)01750-X [pii]
AID - 10.1016/j.envpol.2022.120536 [doi]
PST - ppublish
SO  - Environ Pollut. 2023 Jan 1;316(Pt 1):120536. doi: 10.1016/j.envpol.2022.120536. 
      Epub 2022 Oct 29.