PMID- 36368114
OWN - NLM
STAT- MEDLINE
DCOM- 20221122
LR  - 20221122
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 247
DP  - 2022 Dec 1
TI  - Combined effects of multiple metals on hearing loss: A Bayesian kernel machine 
      regression approach.
PG  - 114279
LID - S0147-6513(22)01119-8 [pii]
LID - 10.1016/j.ecoenv.2022.114279 [doi]
AB  - BACKGROUND: Exposure to heavy elements is considered one of the risks of hearing 
      loss. The combined effect of multiple metals on different hearing losses has not 
      been extensively studied. METHODS: This study deals with the association between 
      different metals (Ba, Cd, Co, Cs, Mo, Pb, Mn, Sn, Sb, Tl, W) and hearing loss in 
      the 2013-2018 National Health and Nutrition Examination Survey (NHANES). 
      Associations were estimated by a generalized linear regression model (GLM) 
      adjusting for age, gender, race/ethnicity, educational level, marital status, 
      drinking status, hypertension, diabetes, smoking status, noise exposure, body 
      mass index, and income-poverty ratio. The joint effects of mixed exposure were 
      assessed by weighted quantile sum (WQS) model and Bayesian kernel machine 
      regression (BKMR). The effect of multiple metals on speech-frequency hearing loss 
      (SFHL) and high-frequency hearing loss (HFHL) was further calculated. The odds 
      ratio (OR) indicates the risk of every metal exposure. RESULTS: A total of 2205 
      adult participants were enrolled from NHANES. Cd, Pb, Sb and Sn had significant 
      effects on total hearing loss. The WQS model found that mixed exposure to heavy 
      elements was significantly positively associated with total hearing loss (OR: 
      1.136; 95% CI: 1.031, 1.253) after adjusting for various covariates. The ORs of 
      mixed exposure in the SFHL and HFHL groups were 1.066 (95% CI: 0.994, 1.143) and 
      1.102 (95% CI: 1.013, 1.199), respectively. BKMR found a significant positive 
      association between multiple metals and hearing loss. The results showed that 
      there may be potential interactions between Cd, Pb and other metals. CONCLUSIONS: 
      Multiple metals have joint effects on hearing loss in the United States. The 
      findings provide practitioners with important scientific evidence for possible 
      interventions.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Liang, Mingming
AU  - Liang M
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Anhui 
      Medical University, Hefei 230032, Anhui, PR China.
FAU - Guo, Xianwei
AU  - Guo X
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Anhui 
      Medical University, Hefei 230032, Anhui, PR China.
FAU - Ding, Xiuxiu
AU  - Ding X
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Anhui 
      Medical University, Hefei 230032, Anhui, PR China.
FAU - Song, Qiuxia
AU  - Song Q
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Anhui 
      Medical University, Hefei 230032, Anhui, PR China.
FAU - Wang, Hao
AU  - Wang H
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Anhui 
      Medical University, Hefei 230032, Anhui, PR China.
FAU - Li, Ning
AU  - Li N
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Anhui 
      Medical University, Hefei 230032, Anhui, PR China.
FAU - Su, Wanying
AU  - Su W
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Anhui 
      Medical University, Hefei 230032, Anhui, PR China.
FAU - Liang, Qiwei
AU  - Liang Q
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Anhui 
      Medical University, Hefei 230032, Anhui, PR China.
FAU - Sun, Yehuan
AU  - Sun Y
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Anhui 
      Medical University, Hefei 230032, Anhui, PR China. Electronic address: 
      yhsun_ahmu_edu@yeah.net.
LA  - eng
PT  - Journal Article
DEP - 20221108
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 00BH33GNGH (Cadmium)
RN  - 2P299V784P (Lead)
SB  - IM
MH  - Humans
MH  - Adult
MH  - Nutrition Surveys
MH  - Bayes Theorem
MH  - *Cadmium/toxicity
MH  - Lead
MH  - *Hearing Loss/chemically induced/epidemiology
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Cadmium
OT  - Generalized linear model
OT  - Hearing loss
OT  - Heavy element
OT  - Weighted quantile sum model
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/11/12 06:00
MHDA- 2022/11/23 06:00
CRDT- 2022/11/11 18:17
PHST- 2022/05/26 00:00 [received]
PHST- 2022/10/15 00:00 [revised]
PHST- 2022/11/06 00:00 [accepted]
PHST- 2022/11/12 06:00 [pubmed]
PHST- 2022/11/23 06:00 [medline]
PHST- 2022/11/11 18:17 [entrez]
AID - S0147-6513(22)01119-8 [pii]
AID - 10.1016/j.ecoenv.2022.114279 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2022 Dec 1;247:114279. doi: 10.1016/j.ecoenv.2022.114279. 
      Epub 2022 Nov 8.