PMID- 36368163
OWN - NLM
STAT- MEDLINE
DCOM- 20221129
LR  - 20221129
IS  - 1872-6283 (Electronic)
IS  - 0379-0738 (Linking)
VI  - 341
DP  - 2022 Dec
TI  - Cardiac troponin T as a postmortem biomarker for acute myocardial infarction.
PG  - 111506
LID - S0379-0738(22)00336-X [pii]
LID - 10.1016/j.forsciint.2022.111506 [doi]
AB  - The diagnosis of acute myocardial infarction (AMI), especially within the first 
      hours after onset of ischemia, poses a challenge to the forensic pathologist. 
      During this time, the infarction is generally not visible macroscopically nor 
      with routine histology. Whilst cardiac Troponin T (cTnT) is a well-established 
      biomarker for AMI clinically, its use as a postmortem diagnostic tool is less 
      conclusive, warranting further investigation. The aim of this study was to 
      investigate the sensitivity and specificity of cTnT as a postmortem diagnostic 
      marker of AMI and the impact of postmortem interval (PMI) and cardiopulmonary 
      resuscitation (CPR) on cTnT-concentrations. Samples from 64 subjects, 15 AMI 
      cases and 49 controls, were collected at the Department of Forensic Medicine in 
      Stockholm and analyzed for cTnT: one femoral blood sample was taken at arrival of 
      the body to the morgue, and again during autopsy. Pericardial fluid (PCF) was 
      only collected during autopsy. Sensitivity and specificity for serum cTnT were 
      calculated to be 86.7 %/67.3 % and for pericardial fluid 86.7 %/44.9 %. cTnT 
      samples taken during autopsy were generally higher than samples taken upon 
      arrival to the morgue. A CPR-dependent elevation in serum cTnT was noted 
      (P = .005). With a cut off at 56 n/L, serum cTnT can be used to rule out AMI. The 
      postmortem interval and CPR must be taken into consideration when interpreting 
      postmortem cTnT.
CI  - Copyright (c) 2022 The Author(s). Published by Elsevier B.V. All rights reserved.
FAU - Moridi, Michael
AU  - Moridi M
AD  - Karolinska Institutet, Solnavagen 1, SE-171 77 Solna, Sweden.
FAU - Magnusson, Cecilia
AU  - Magnusson C
AD  - Karolinska Institutet, Solnavagen 1, SE-171 77 Solna, Sweden.
FAU - Zilg, Brita
AU  - Zilg B
AD  - Karolinska Institutet, Solnavagen 1, SE-171 77 Solna, Sweden; Department of 
      Forensic Medicine, Swedish National Board of Forensic Medicine, Retzius vag 5, 
      SE-171 65, Stockholm, Sweden. Electronic address: brita.zilg@ki.se.
LA  - eng
PT  - Journal Article
DEP - 20221028
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
RN  - 0 (Troponin T)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Troponin T
MH  - Autopsy
MH  - *Myocardial Infarction/diagnosis
MH  - Biomarkers
MH  - Morgue
MH  - *Pericardial Effusion
OTO - NOTNLM
OT  - Acute myocardial infarction
OT  - Ischemic heart disease
OT  - Postmortem biochemistry
OT  - Troponin-T
EDAT- 2022/11/12 06:00
MHDA- 2022/11/30 06:00
CRDT- 2022/11/11 18:22
PHST- 2022/08/04 00:00 [received]
PHST- 2022/10/17 00:00 [revised]
PHST- 2022/10/26 00:00 [accepted]
PHST- 2022/11/12 06:00 [pubmed]
PHST- 2022/11/30 06:00 [medline]
PHST- 2022/11/11 18:22 [entrez]
AID - S0379-0738(22)00336-X [pii]
AID - 10.1016/j.forsciint.2022.111506 [doi]
PST - ppublish
SO  - Forensic Sci Int. 2022 Dec;341:111506. doi: 10.1016/j.forsciint.2022.111506. Epub 
      2022 Oct 28.