PMID- 36368257
OWN - NLM
STAT- MEDLINE
DCOM- 20221206
LR  - 20230125
IS  - 1532-1983 (Electronic)
IS  - 0261-5614 (Linking)
VI  - 41
IP  - 12
DP  - 2022 Dec
TI  - Association of copper exposure with prevalence of chronic kidney disease in older 
      adults.
PG  - 2720-2728
LID - S0261-5614(22)00377-6 [pii]
LID - 10.1016/j.clnu.2022.10.016 [doi]
AB  - BACKGROUND & AIMS: Metal exposure is suspected to be associated with the risk of 
      chronic kidney disease (CKD). Copper (Cu) is an essential yet toxic trace element 
      in humans. Epidemiological evidence on the association of Cu exposure with CKD 
      remains inconsistent. This study aims to investigate the association of blood Cu 
      and its co-exposure to other metals with CKD. METHODS: A cross-sectional study 
      was conducted among 3285 older participants in Zhejiang, China. The whole blood 
      levels of Cu as well as other 10 metals were measured using the inductively 
      coupled plasma mass spectrometry (ICP-MS). CKD events were defined as the 
      presence of albuminuria or estimated glomerular filtration rate 
      (eGFR) < 60 mL/min/1.73 m(2). Multivariable logistic regression and linear 
      regression models were applied to assess the association of Cu with kidney 
      function. The Bayesian kernel machine regression (BKMR) was used to examine the 
      association of metal interactions with CKD. RESULTS: In logistic models, we found 
      a dose-dependent positive association between blood Cu and the prevalence of CKD. 
      Compared to the lowest quartile of blood Cu, the odds ratio (OR) of CKD in the 
      highest quartile was 1.65 (95% confidence interval, CI: 1.25, 2.17), and the beta of 
      eGFR was -1.74 (95% CI: -3.15, -0.34) after adjusting for multiple covariates. 
      The positive linear dose-response association was found between blood Cu and the 
      OR of CKD, and negative linear association was found between Cu and the beta of 
      eGFR. The positive association between blood Cu and CKD risk was stronger at 
      lower level of manganese (Mn) in the BKMR model. CONCLUSION: The whole blood 
      level of Cu was remarkably associated with the risk of CKD and showed positive 
      dose-response relationships in the older Chinese population. The toxicity of Cu 
      on kidney function could be antagonized by the exposure of Mn. These findings 
      shed new light on the potential role of Cu in kidney health.
CI  - Copyright (c) 2022 Elsevier Ltd and European Society for Clinical Nutrition and 
      Metabolism. All rights reserved.
FAU - Guo, Fanjia
AU  - Guo F
AD  - Department of Public Health, Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou 310058, China.
FAU - Lin, Yaoyao
AU  - Lin Y
AD  - Department of Public Health, Fourth Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou 310058, China.
FAU - Meng, Lin
AU  - Meng L
AD  - Department of Public Health, Fourth Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou 310058, China.
FAU - Peng, Lihe
AU  - Peng L
AD  - Physical and Chemical Laboratory, Center for Disease Control and Prevention, 
      Jiashan County, Jiaxing, Zhejiang Province, 314100, China.
FAU - Zhang, Huafang
AU  - Zhang H
AD  - Department of Nursing, The Fourth Affiliated Hospital, Zhejiang University School 
      of Medicine, Yiwu 322000, China.
FAU - Zhang, Xue
AU  - Zhang X
AD  - Physical and Chemical Laboratory, Center for Disease Control and Prevention, 
      Jiashan County, Jiaxing, Zhejiang Province, 314100, China.
FAU - Jin, Mingjuan
AU  - Jin M
AD  - Department of Public Health, Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou 310058, China.
FAU - Wang, Jianbing
AU  - Wang J
AD  - Department of Public Health, National Clinical Research Center for Child Health 
      of Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, 
      China.
FAU - Zhang, Yongming
AU  - Zhang Y
AD  - The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 
      322000, China. Electronic address: zymcool@zju.edu.cn.
FAU - Tang, Mengling
AU  - Tang M
AD  - Department of Public Health, Fourth Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou 310058, China. Electronic address: 
      tangml@zju.edu.cn.
FAU - Chen, Kun
AU  - Chen K
AD  - Department of Public Health, Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou 310058, China. Electronic address: ck@zju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221027
PL  - England
TA  - Clin Nutr
JT  - Clinical nutrition (Edinburgh, Scotland)
JID - 8309603
RN  - 789U1901C5 (Copper)
SB  - IM
MH  - Humans
MH  - Aged
MH  - *Copper
MH  - Prevalence
MH  - Cross-Sectional Studies
MH  - Bayes Theorem
MH  - *Renal Insufficiency, Chronic
MH  - Glomerular Filtration Rate
OTO - NOTNLM
OT  - BKMR analysis
OT  - Chronic kidney disease
OT  - Copper
OT  - Manganese
OT  - Whole blood
COIS- Conflicts of interest All authors declare that they have no known actual or 
      potential competing financial interests.
EDAT- 2022/11/12 06:00
MHDA- 2022/12/07 06:00
CRDT- 2022/11/11 18:32
PHST- 2022/05/13 00:00 [received]
PHST- 2022/08/21 00:00 [revised]
PHST- 2022/10/20 00:00 [accepted]
PHST- 2022/11/12 06:00 [pubmed]
PHST- 2022/12/07 06:00 [medline]
PHST- 2022/11/11 18:32 [entrez]
AID - S0261-5614(22)00377-6 [pii]
AID - 10.1016/j.clnu.2022.10.016 [doi]
PST - ppublish
SO  - Clin Nutr. 2022 Dec;41(12):2720-2728. doi: 10.1016/j.clnu.2022.10.016. Epub 2022 
      Oct 27.