PMID- 36369892
OWN - NLM
STAT- MEDLINE
DCOM- 20230504
LR  - 20230505
IS  - 1349-7006 (Electronic)
IS  - 1347-9032 (Print)
IS  - 1347-9032 (Linking)
VI  - 114
IP  - 5
DP  - 2023 May
TI  - Clinicopathological features and prognostic impact of dirty necrosis in 
      metastatic lung cancers from the colon and rectum.
PG  - 2169-2177
LID - 10.1111/cas.15647 [doi]
AB  - Dirty necrosis (DN) is a form of tumor necrosis (TN) with prominent neutrophil 
      infiltration and cell detritus in the necrotic foci. This study aimed to 
      characterize the clinicopathological features of DN in metastatic lung cancers of 
      the colon and rectum (MLCRs). A total of 227 patients who underwent pulmonary 
      metastasectomy and complete resection for MLCR were included in this study. TN 
      was evaluated using digitally scanned resection specimens. These slides were 
      immunostained for biomarkers of NETosis (citrullinated histone H3 [citH3] and 
      myeloperoxidase [MPO]), and the area positive for citH3 and MPO was further 
      quantified. TN was observed in 216 cases (95.2%), and 54 (25.0%) of these cases 
      had DN. The presence of TN was not associated with a worse prognosis; however, 
      patients with DN had a significantly shorter overall survival than those without 
      DN (p < 0.01). Furthermore, the presence of DN was a poor prognostic factor in 
      both the univariate and multivariate analyses. Immunohistochemical analysis 
      revealed that the percentage of citH3-positive and MPO-positive areas in the 
      DN-positive cases was significantly higher than that in the DN-negative cases 
      (p < 0.01 and p < 0.01, respectively). In surgically resected MLCR, DN is the 
      characteristic TN subtype associated with poor prognosis and neutrophil 
      extracellular traps (NETs).
CI  - (c) 2022 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd 
      on behalf of Japanese Cancer Association.
FAU - Konishi, Yasuhito
AU  - Konishi Y
AD  - Department of Pathology and Clinical Laboratories, National Cancer Center 
      Hospital East, Kashiwa, Japan.
AD  - Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, 
      Japan.
AD  - Departments of General Thoracic Surgery, Juntendo University School of Medicine, 
      Tokyo, Japan.
FAU - Taki, Tetsuro
AU  - Taki T
AD  - Department of Pathology and Clinical Laboratories, National Cancer Center 
      Hospital East, Kashiwa, Japan.
FAU - Nakai, Tokiko
AU  - Nakai T
AD  - Department of Pathology and Clinical Laboratories, National Cancer Center 
      Hospital East, Kashiwa, Japan.
FAU - Kuroe, Takashi
AU  - Kuroe T
AUID- ORCID: 0000-0002-2366-2467
AD  - Department of Pathology and Clinical Laboratories, National Cancer Center 
      Hospital East, Kashiwa, Japan.
FAU - Morisue, Ryo
AU  - Morisue R
AD  - Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, 
      National Cancer Center, Kashiwa, Japan.
AD  - Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center 
      Hospital East, Kashiwa, Japan.
FAU - Miyoshi, Tomohiro
AU  - Miyoshi T
AD  - Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, 
      Japan.
FAU - Tane, Kenta
AU  - Tane K
AUID- ORCID: 0000-0002-7737-8277
AD  - Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, 
      Japan.
FAU - Samejima, Joji
AU  - Samejima J
AD  - Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, 
      Japan.
FAU - Aokage, Keiju
AU  - Aokage K
AD  - Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, 
      Japan.
FAU - Miyazaki, Saori
AU  - Miyazaki S
AD  - Department of Pathology and Clinical Laboratories, National Cancer Center 
      Hospital East, Kashiwa, Japan.
FAU - Sakamoto, Naoya
AU  - Sakamoto N
AUID- ORCID: 0000-0001-6273-0189
AD  - Department of Pathology and Clinical Laboratories, National Cancer Center 
      Hospital East, Kashiwa, Japan.
AD  - Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, 
      National Cancer Center, Kashiwa, Japan.
FAU - Sakashita, Shingo
AU  - Sakashita S
AD  - Department of Pathology and Clinical Laboratories, National Cancer Center 
      Hospital East, Kashiwa, Japan.
AD  - Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, 
      National Cancer Center, Kashiwa, Japan.
FAU - Watanabe, Reiko
AU  - Watanabe R
AD  - Department of Pathology and Clinical Laboratories, National Cancer Center 
      Hospital East, Kashiwa, Japan.
FAU - Kojima, Motohiro
AU  - Kojima M
AUID- ORCID: 0000-0002-6150-6545
AD  - Department of Pathology and Clinical Laboratories, National Cancer Center 
      Hospital East, Kashiwa, Japan.
AD  - Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, 
      National Cancer Center, Kashiwa, Japan.
FAU - Suzuki, Kenji
AU  - Suzuki K
AD  - Departments of General Thoracic Surgery, Juntendo University School of Medicine, 
      Tokyo, Japan.
FAU - Tsuboi, Masahiro
AU  - Tsuboi M
AD  - Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, 
      Japan.
FAU - Ishii, Genichiro
AU  - Ishii G
AUID- ORCID: 0000-0001-8637-3323
AD  - Department of Pathology and Clinical Laboratories, National Cancer Center 
      Hospital East, Kashiwa, Japan.
AD  - Division of Innovative Pathology and Laboratory Medicine, Exploratory Oncology 
      Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
LA  - eng
GR  - 21H02931/JSPS KAKENHI/
PT  - Journal Article
DEP - 20221220
PL  - England
TA  - Cancer Sci
JT  - Cancer science
JID - 101168776
RN  - 0 (Histones)
SB  - IM
MH  - Humans
MH  - Prognosis
MH  - *Rectum/pathology
MH  - Histones
MH  - *Lung Neoplasms/surgery/pathology
MH  - Colon/pathology
MH  - Necrosis
MH  - Neutrophils/pathology
PMC - PMC10154810
OTO - NOTNLM
OT  - NETosis
OT  - colon and rectum
OT  - dirty necrosis
OT  - metastatic lung cancer
OT  - tumor necrosis
COIS- Dr. Genichiro Ishii is an editorial board member of Cancer Science.
EDAT- 2022/11/13 06:00
MHDA- 2023/05/04 12:42
PMCR- 2022/12/20
CRDT- 2022/11/12 03:12
PHST- 2022/10/28 00:00 [revised]
PHST- 2022/08/02 00:00 [received]
PHST- 2022/11/01 00:00 [accepted]
PHST- 2023/05/04 12:42 [medline]
PHST- 2022/11/13 06:00 [pubmed]
PHST- 2022/11/12 03:12 [entrez]
PHST- 2022/12/20 00:00 [pmc-release]
AID - CAS15647 [pii]
AID - 10.1111/cas.15647 [doi]
PST - ppublish
SO  - Cancer Sci. 2023 May;114(5):2169-2177. doi: 10.1111/cas.15647. Epub 2022 Dec 20.