PMID- 36370225
OWN - NLM
STAT- MEDLINE
DCOM- 20230113
LR  - 20230202
IS  - 1573-7365 (Electronic)
IS  - 0885-7490 (Linking)
VI  - 38
IP  - 1
DP  - 2023 Jan
TI  - Light-intensity exercise improves memory dysfunction with the restoration of 
      hippocampal MCT2 and miRNAs in type 2 diabetic mice.
PG  - 245-254
LID - 10.1007/s11011-022-01117-y [doi]
AB  - Cognitive decline associated with type 2 diabetes mellitus (T2DM) is a risk 
      factor to impair human health. Although light-intensity exercise prevents 
      hippocampal memory dysfunction in pre-symptomatic T2DM animals by altering 
      hippocampal lactate transport and neurotrophic factors, the effects of 
      light-intensity exercise in an advanced stage of T2DM animals remain unclear. 
      Here, ob/ob mice, an animal model of T2DM, were subjected to light-intensity 
      exercise (5.0 m/min) for 30 min/day, five days/week for four weeks. The effects 
      of light-intensity exercise on hippocampal complications, mRNA expressions of 
      monocarboxylate transporter (MCT), and miRNA levels were assessed. The 
      light-intensity exercise improved hippocampal memory retention in ob/ob mice. 
      Downregulated hippocampal Mct2 mRNA levels in T2DM were improved with 
      light-intensity exercise. Hippocampal mRNA levels of Mct1 and Mct4 were unchanged 
      within groups. Based on miRNA sequencing, sedentary ob/ob mice exhibited that 71 
      miRNAs were upregulated, and 77 miRNAs were downregulated in the hippocampus. In 
      addition, the exercise significantly increased 24 miRNAs and decreased 4 miRNAs 
      in the T2DM hippocampus. The exercise reversed T2DM-induced alterations of 
      hippocampal 9 miRNAs, including miR-200a-3p. Our findings imply that 
      miR-200a-3p/Mct2 in the hippocampus would be a possible clinical target for 
      treating T2DM-induced memory dysfunction.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Shima, Takeru
AU  - Shima T
AUID- ORCID: 0000-0003-4209-1564
AD  - Department of Health and Physical Education, Cooperative Faculty of Education, 
      Gunma University, 4-2 Aramaki-machi, Gunma, 371-8510, Maebashi, Japan. 
      ta-shima@gunma-u.ac.jp.
FAU - Kawabata-Iwakawa, Reika
AU  - Kawabata-Iwakawa R
AUID- ORCID: 0000-0002-3504-1393
AD  - Division of Integrated Oncology Research, Gunma University Initiative for 
      Advanced Research, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan.
FAU - Onishi, Hayate
AU  - Onishi H
AD  - Department of Health and Physical Education, Cooperative Faculty of Education, 
      Gunma University, 4-2 Aramaki-machi, Gunma, 371-8510, Maebashi, Japan.
FAU - Jesmin, Subrina
AU  - Jesmin S
AUID- ORCID: 0000-0003-0165-827X
AD  - Faculty of Medicine, Toho University Graduate School of Medicine, 5-21-16 
      Omorinishi, Ota-ku, 143-0015, Tokyo, Japan.
FAU - Yoshikawa, Tomonori
AU  - Yoshikawa T
AD  - Department of Health and Physical Education, Cooperative Faculty of Education, 
      Gunma University, 4-2 Aramaki-machi, Gunma, 371-8510, Maebashi, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221112
PL  - United States
TA  - Metab Brain Dis
JT  - Metabolic brain disease
JID - 8610370
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Humans
MH  - Mice
MH  - Animals
MH  - *Diabetes Mellitus, Type 2/complications/therapy/metabolism
MH  - *MicroRNAs/genetics/metabolism
MH  - *Diabetes Mellitus, Experimental/metabolism
MH  - Hippocampus/metabolism
MH  - Memory
OTO - NOTNLM
OT  - Light-intensity exercise
OT  - Memory function
OT  - Monocarboxylate transporter
OT  - Type 2 diabetes
OT  - miR-Seq
EDAT- 2022/11/13 06:00
MHDA- 2023/01/14 06:00
CRDT- 2022/11/12 11:16
PHST- 2022/06/15 00:00 [received]
PHST- 2022/10/28 00:00 [accepted]
PHST- 2022/11/13 06:00 [pubmed]
PHST- 2023/01/14 06:00 [medline]
PHST- 2022/11/12 11:16 [entrez]
AID - 10.1007/s11011-022-01117-y [pii]
AID - 10.1007/s11011-022-01117-y [doi]
PST - ppublish
SO  - Metab Brain Dis. 2023 Jan;38(1):245-254. doi: 10.1007/s11011-022-01117-y. Epub 
      2022 Nov 12.