PMID- 36370798
OWN - NLM
STAT- MEDLINE
DCOM- 20221222
LR  - 20221222
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 858
IP  - Pt 3
DP  - 2023 Feb 1
TI  - Association between exposure to phenols and parabens and cognitive function in 
      older adults in the United States: A cross-sectional study.
PG  - 160129
LID - S0048-9697(22)07229-1 [pii]
LID - 10.1016/j.scitotenv.2022.160129 [doi]
AB  - BACKGROUND: People are commonly exposed to mixtures of parabens and phenols. Most 
      studies investigating such exposure and cognitive performance tend to assess only 
      single chemicals, and the tools used to assess cognitive function are not 
      uniform. OBJECTIVE: This study aimed to examine the association between multiple 
      parabens and phenols and cognitive function in older Americans. METHODS: The 
      study included data of older Americans from two cycles of the NHANES survey. 
      Participants were divided into normal cognitive performance and low cognitive 
      performance groups based on the scores of four cognitive tests: the Immediate 
      Recall test (IRT), the Delayed Recall test (DRT), the Animal Fluency test (AFT) 
      and the Digit Symbol Substitution test (DSST). Generalized linear regression 
      models (GLMs), restricted cubic spline (RCS), weighted quantile sum (WQS) and 
      Bayesian kernel machine regression (BKMR) were used to assess relationships 
      between chemical exposure and cognitive performance. RESULTS: In this 
      cross-sectional study, a total of 961 participants, 470 males and 491 females, 
      were included. GLMs revealed positive association between high levels of 
      bisphenol A (BPA) and low cognitive performance on DRT, especially in male (OR 
      (95%CI): 2.25 (1.10-4.61)), and this association was consistent with WQS and 
      BKMR. In female participants, the third quartile of BPA exposure showed a 
      positive association with low cognition on IRT and global cognition. GLMs also 
      showed that high levels of propylparaben were positively associated with 
      cognitive performance on the IRT in male participants (OR (95%CI): 0.37 
      (0.18-0.76)). In BKMR, an overall positive correlation between the mixture and 
      low cognition as measured with DRT was observed in male subjects when the mixture 
      was at the 65th percentile or higher. CONCLUSION: Exposure to a mixture of 
      parabens and phenols was positively associated with low cognitive performance on 
      DRT in older male subjects, while BPA was the main driver of this outcome.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Shi, Yisen
AU  - Shi Y
AD  - Fujian Medical University, Fuzhou 35001, China; Department of Neurology, Fujian 
      Medical University Union Hospital, Fuzhou 35001, China.
FAU - Wang, Huaicheng
AU  - Wang H
AD  - Fujian Medical University, Fuzhou 35001, China.
FAU - Zhu, Zhibao
AU  - Zhu Z
AD  - Department of Neurology, Fujian Institute of Geriatrics, Fujian Medical 
      University Union Hospital, Fuzhou 350001, Fujian, China; Fujian Key Laboratory of 
      Molecular Neurology, Institute of Neuroscience, Fujian Medical University, 88 
      Jiaotong Road, Fuzhou 350005, Fujian, China.
FAU - Ye, Qinyong
AU  - Ye Q
AD  - Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 35001, 
      China.
FAU - Lin, Fabin
AU  - Lin F
AD  - Department of Neurosurgery, Fujian Medical University Union Hospital, Fuzhou 
      35001, China. Electronic address: fabinlin@fjmu.edu.cn.
FAU - Cai, Guoen
AU  - Cai G
AD  - Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 35001, 
      China. Electronic address: cgessmu@fjmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20221109
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
SB  - IM
MH  - Animals
MH  - Female
MH  - Male
MH  - Bayes Theorem
MH  - *Cognition
MH  - Cross-Sectional Studies
MH  - Nutrition Surveys
MH  - United States
OTO - NOTNLM
OT  - BKMR
OT  - Chemical mixtures
OT  - WQS
COIS- Declaration of competing interest The authors declare no actual or potential 
      conflicts of interest.
EDAT- 2022/11/13 06:00
MHDA- 2022/12/15 06:00
CRDT- 2022/11/12 19:33
PHST- 2022/08/12 00:00 [received]
PHST- 2022/10/09 00:00 [revised]
PHST- 2022/11/07 00:00 [accepted]
PHST- 2022/11/13 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/11/12 19:33 [entrez]
AID - S0048-9697(22)07229-1 [pii]
AID - 10.1016/j.scitotenv.2022.160129 [doi]
PST - ppublish
SO  - Sci Total Environ. 2023 Feb 1;858(Pt 3):160129. doi: 
      10.1016/j.scitotenv.2022.160129. Epub 2022 Nov 9.