PMID- 36371805 OWN - NLM STAT- MEDLINE DCOM- 20230512 LR - 20230613 IS - 1758-535X (Electronic) IS - 1079-5006 (Linking) VI - 78 IP - 5 DP - 2023 May 11 TI - Mitochondrial Dysfunction and Intrinsic Capacity: Insights From a Narrative Review. PG - 735-742 LID - 10.1093/gerona/glac227 [doi] AB - Mitochondrial dysfunction occurs during aging and may play a role, by distinct mechanisms, in the loss of intrinsic capacity (IC), operationalized through 5 domains: locomotion, psychological, cognition, vitality/nutrition, and sensory (hearing, vision). The objective of this review is to provide an overview of the associations between mitochondrial function and IC domains. This study is a narrative review of original investigations (any study design) on the relationship of mitochondrial function in humans with locomotion (eg, gait speed), psychological (eg, depressive symptoms), cognition (eg, global cognitive function), vitality (eg, handgrip strength), and/or sensory (hearing and vision acuity) domains. The IC domains were considered from the perspective of the Integrated Care for Older People (ICOPE), according to the World Health Organization guidelines. The results show that there is still limited evidence regarding the associations between mitochondrial function and IC domains. Most studies were cross-sectional and involved small samples. The tissues/cells most often investigated in the original studies were skeletal muscle and peripheral blood mononuclear cells. The available evidence, although limited, indicates that mitochondrial function, in particular, the mitochondrial DNA copy number, is associated with all IC domains. The evidence is more robust for locomotion and less abundant for hearing. In conclusion, this review supports the notion that mitochondrial function is correlated with IC domains by distinct mechanisms. Future studies are needed to confirm whether mitochondria play a role in maintaining optimal function and preventing/delaying the onset of disability during aging, which could ultimately contribute to healthy aging. CI - (c) The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. FAU - Aragoni da Silva, Jaqueline AU - Aragoni da Silva J AUID- ORCID: 0000-0001-6344-9073 AD - Institut du Vieillissement, Gerontopole de Toulouse, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France. FAU - Rolland, Yves AU - Rolland Y AD - Institut du Vieillissement, Gerontopole de Toulouse, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France. AD - CERPOP UMR 1295, University of Toulouse III, Institut National de la Sante et de la Recherche Medicale (Inserm), UPS, Toulouse, France. FAU - Martinez, Laurent O AU - Martinez LO AD - Institut des Maladies Metaboliques et Cardiovasculaires, I2MC, Universite de Toulouse, INSERM, Universite Toulouse III - Paul Sabatier (UPS), UMR1297, Toulouse, France. FAU - de Souto Barreto, Philipe AU - de Souto Barreto P AD - Institut du Vieillissement, Gerontopole de Toulouse, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France. AD - CERPOP UMR 1295, University of Toulouse III, Institut National de la Sante et de la Recherche Medicale (Inserm), UPS, Toulouse, France. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - United States TA - J Gerontol A Biol Sci Med Sci JT - The journals of gerontology. Series A, Biological sciences and medical sciences JID - 9502837 SB - IM MH - Humans MH - Aged MH - *Hand Strength MH - *Leukocytes, Mononuclear MH - Cognition/physiology MH - Aging/physiology MH - Mitochondria OTO - NOTNLM OT - Cognitive function OT - Depression OT - Handgrip strength OT - Mitochondria OT - Mobility EDAT- 2022/11/14 06:00 MHDA- 2023/05/12 07:06 CRDT- 2022/11/13 16:12 PHST- 2022/07/05 00:00 [received] PHST- 2023/05/12 07:06 [medline] PHST- 2022/11/14 06:00 [pubmed] PHST- 2022/11/13 16:12 [entrez] AID - 6825581 [pii] AID - 10.1093/gerona/glac227 [doi] PST - ppublish SO - J Gerontol A Biol Sci Med Sci. 2023 May 11;78(5):735-742. doi: 10.1093/gerona/glac227.