PMID- 36371899
OWN - NLM
STAT- MEDLINE
DCOM- 20230307
LR  - 20230307
IS  - 2212-1102 (Electronic)
IS  - 2212-1099 (Linking)
VI  - 34
DP  - 2023 Mar
TI  - Health State Utility Values of Type 2 Diabetes Mellitus and Related 
      Complications: A Systematic Review and Meta-Analysis.
PG  - 14-22
LID - S2212-1099(22)00181-9 [pii]
LID - 10.1016/j.vhri.2022.09.005 [doi]
AB  - OBJECTIVES: This study aims to synthesize health state utility values (HSUVs) of 
      type 2 diabetes mellitus (T2DM) and its related complications published in the 
      literature, conducting a meta-analysis of the data when possible. METHODS: We 
      conducted a systematic search in MEDLINE and School of Health and Related 
      Research Health Utilities Database repository. Studies focused on T2DM and its 
      complications reporting utility values elicited using direct and indirect methods 
      were selected. We categorized the results according to the instrument to describe 
      health and meta-analyzed them accordingly. Data included in the analysis were 
      pooled in a fixed-effect model by the inverse of variance mean and random-effects 
      DerSimonian-Laird method. Two approaches on sensitivity analysis were performed: 
      leave-one-out method and including data of HSUVs obtained by foreign population 
      value sets. RESULTS: We identified 70 studies for the meta-analysis from a total 
      of 467 studies. Sufficient data to pool T2DM HSUVs from EQ-5D instrument, 
      hypoglycemia, and stroke were obtained. HSUVs varied from 0.7 to 0.92 in direct 
      valuations, and the pooled mean of 3-level version of EQ-5D studies was 0.772 
      (95% confidence interval 0.763-0.78) and of 5-level version of EQ-5D 0.815 (95% 
      confidence interval 0.808-0.823). HSUVs of complications varied from 0.739 to 
      0.843, or reductions of HSUVs between -0.014 and -0.094. In general, HSUVs 
      obtained from 3-level version of EQ-5D and Health Utility Index 3 instruments 
      were lower than those directly elicited. A considerable amount of heterogeneity 
      was observed. Some complications remained unable to be pooled due to scarce of 
      original articles. CONCLUSIONS: T2DM and its complications have a considerable 
      impact on health-related quality of life. 5-level version of EQ-5D estimates 
      seems comparable with direct elicited HSUVs.
CI  - Copyright (c) 2022 International Society for Health Economics and Outcomes 
      Research. Published by Elsevier Inc. All rights reserved.
FAU - Redenz, Gunther
AU  - Redenz G
AD  - Escuela de Kinesiologia, Facultad de Medicina, Universidad de los Andes, 
      Santiago, Chile.
FAU - Ibaceta, Marcela Carcamo
AU  - Ibaceta MC
AD  - Departamento de Epidemiologia y estudios en salud, Universidad de los Andes, 
      Santiago, Chile.
FAU - Aceituno, David
AU  - Aceituno D
AD  - Departamento de psiquiatria, Escuela de Medicina, Pontificia Universidad Catolica 
      de Chile, Santiago, Chile.
FAU - Balmaceda, Carlos
AU  - Balmaceda C
AD  - Unidad de Evaluacion de Tecnologias Sanitarias, Centro de Investigaciones 
      Clinicas, Facultad de Medicina, Pontificia Universidad Catolica de Chile, 
      Santiago, Chile.
FAU - Espinoza, Manuel A
AU  - Espinoza MA
AD  - Departamento de Salud Publica, Pontificia Universidad Catolica de Chile, 
      Santiago, Chile. Electronic address: manuel.espinoza@uc.cl.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20221111
PL  - United States
TA  - Value Health Reg Issues
JT  - Value in health regional issues
JID - 101592642
SB  - IM
MH  - Humans
MH  - *Quality of Life
MH  - *Diabetes Mellitus, Type 2
OTO - NOTNLM
OT  - economic evaluation
OT  - health state utility values
OT  - meta-analysis
OT  - type 2 diabetes mellitus
EDAT- 2022/11/14 06:00
MHDA- 2023/03/08 06:00
CRDT- 2022/11/13 18:20
PHST- 2022/06/07 00:00 [received]
PHST- 2022/09/01 00:00 [revised]
PHST- 2022/09/25 00:00 [accepted]
PHST- 2022/11/14 06:00 [pubmed]
PHST- 2023/03/08 06:00 [medline]
PHST- 2022/11/13 18:20 [entrez]
AID - S2212-1099(22)00181-9 [pii]
AID - 10.1016/j.vhri.2022.09.005 [doi]
PST - ppublish
SO  - Value Health Reg Issues. 2023 Mar;34:14-22. doi: 10.1016/j.vhri.2022.09.005. Epub 
      2022 Nov 11.